Adv Search
 
  Office
  About
  Links
PUBMed
www.dxy.cn
More>>  
 
  Visited
    Current Issue
2025 Vol. 12, No. 6
Published: 2025-12-09
 
685 Research progress in appetite-preserving gastrectomy
Chen Wenjing, Cheng Jun
Appetite-preserving gastrectomy APG is a novel function-preserving surgical approach recently proposed in gastric cancer surgery. Its core principle involves the precise preservation of the fundus and fornix—the primary secretion area of ghrelin—to ensure oncological radicality while maintaining postoperative appetite thereby improving nutritional status and quality of life. This article provides a systematic review of the definition theoretical foundation clinical efficacy current controversies and future directions of APG. Current evidence suggests that APG demonstrates favorable perioperative safety in patients with esophagogastric junction cancer and offers advantages in short - term appetite preservation weight change and nutritional indicators. However controversies remain regarding its long-term oncological safety certainty of functional benefits and patient selection criteria. There is an urgent need for large-scale multi-center randomized controlled trials to provide higher-level evidence. Future development of APG should focus on precise patient selection technical standardization application of minimally invasive platforms and multidisciplinary integrated management to promote its advancement toward a safer more effective and individualized approach.
2025 Vol. 12 (6): 685-690 [Abstract] ( 69 ) HTML PDF (1240 KB)  ( 13 )
691 Current research landscape on anemia after bariatric and metabolic surgery
Guo Peisen, Yu Jiahui, Yang Huawu
Bariatric and metabolic surgery BMS is an important method for treating obesity and metabolic diseases yet it is frequently associated with postoperative complications. Anemia is a common complication with its incidence influenced by factors such as country surgical technique and follow-up duration. The primary cause is impaired nutrient absorption post-surgery leading to deficiencies in iron vitamin B12 folic acid and copper. Additionally peptic ulcers and menstrual blood loss are significant contributing factors. Conditions such as refractory iron deficiency anemia thalassemia and Helicobacter pylori infection may further elevate the risk of postoperative anemia. The treatment of iron deficiency anemia after BMS should adopt a stepwise management approach. First dietary modification to increase nutrient-rich food intake is recommended. If ineffective oral supplementation should be initiated. For patients with malabsorption or severe anemia intravenous supplementation can rapidly replenish nutrient reserves. Clinically individualized plans should be formulated in combination with the patient's surgical method nutritional status and comorbidities. Concurrently screening and addressing specific underlying causes are crucial to reduce the incidence of postoperative anemia and optimize treatment outcomes.
2025 Vol. 12 (6): 691-697 [Abstract] ( 85 ) HTML PDF (2648 KB)  ( 16 )
698 Research progress on the mechanism of mindful eating in obese patients
1Li Qingjiao,2Tang Lu,3Cai Hua
The global epidemic of obesity has underscored the critical need for innovative approaches to traditional intervention strategies. Mindful eating intervention MEI an interdisciplinary approach integrating behavioral medicine and nutritional psychology represents a promising paradigm for obesity management. This review systematically examines the multidimensional mechanisms underlying MEI at the neurophysiological level MEI modulates metabolic homeostasis through the regulation of satiety signaling pathways gastrointestinal motility and hormonal secretion while simultaneously enhancing dietary decision-making via the inhibition of reward circuits activation of executive control networks and functional optimization of the insular cortex at the psychological level MEI facilitates the differentiation between emotional states and physiological hunger thereby mitigating stressinduced hyperphagia. Future research directions should incorporate advanced methodologies including genomic profiling and virtual reality-based interventions to facilitate the translation of MEI from theoretical frameworks to clinical applications thereby offering comprehensive interdisciplinary solutions for the prevention and treatment of obesity.
2025 Vol. 12 (6): 698-703 [Abstract] ( 101 ) HTML PDF (928 KB)  ( 27 )
704 Fat reduction and muscle gain integrated strategies for long-term management after metabolic and bariatric surgery
1Huang Linya,1Yang Yi,1,2Chen Yanming
Metabolic and bariatric surgery MBS is a pivotal intervention for severe obesity and its comorbidities. However the significant loss of lean body mass and the associated risk of sarcopenia following surgery present major challenges to long-term patient health. The review aims to systematically summarize the dynamic changes in body composition following MBS and to discuss scientific management strategies focused on optimizing body composition. Ideal postoperative management should go beyond short - term improvements in weight and metabolic parameters it should be based on scientific principles striving to minimize fat mass particularly visceral adipose tissue while preserving or even increasing lean body mass. Achieving this goal hinges on implementing a multidimensional personalized and sustained comprehensive intervention strategy. The core components of this strategy include phased and adequate protein supplementation to stimulate muscle protein synthesis and mitigate lean tissue loss personalized exercise prescriptions combining resistance and aerobic training to synergistically promote muscle anabolism improve insulin sensitivity and prevent weight regain and a long - term multidisciplinary follow - up model that integrates expertise from nutrition physical rehabilitation endocrinology and surgical team to provide continuous patient support and education thereby ensuring long - term adherence. In conclusion implementing this body composition-focused management framework is critical for consolidating the lasting benefits of surgery and enhancing overall metabolic health and quality of life.
2025 Vol. 12 (6): 704-709 [Abstract] ( 55 ) HTML PDF (1433 KB)  ( 14 )
710 Construction and validation of a lung cancer risk prediction model based on blood fatty acid profiles a multicenter retrospective study
1,2Liu Xiangrong,3Jiang Mingming,2Liu Lu,2Zhang Xinsheng,2Liu Zhao,4Yang Bo,1,2Liu Yinghua
Objective This study aimed to establish an interpretable predictive model for assessing the risk of lung cancer occurrence using human blood fatty acid levels thereby promoting the prevention and early diagnosis of lung cancer. Method Clinical and blood fatty acid data from 1 837 patients with lung cancer 1194 cases or non - tumorous 643 cases conditions were retrospectively collected from June 2023 to June 2025 at the First Medical Center 1677 cases and the Eighth Medical Center 160 cases of the Chinese PLA General Hospital. By setting a random number seed the dataset from the First Medical Center of the PLA General Hospital was randomly split into a training set and an internal validation set at a ratio of 7 ∶ 3 while the dataset from the Eighth Medical Center was designated as the external validation set. Five models—random forest extreme gradient boosting support vector machine SVM classification and regression tree and logistic regression—were developed to predict the risk of lung cancer. The predictive performance of the five models was compared using the area under the receiver operating characteristic curve decision curve analysis and calibration curves and the optimal model was selected. The SHapley additive explanations method was used to interpret the SVM model. Result A clinical prediction model was established incorporating 17 predictors including age palmitic acid palmitoleic acid linoleic acid γ - linolenic acid α - linolenic acid arachidonic acid eicosapentaenoic acid docosahexaenoic acid total monounsaturated fatty acids total polyunsaturated fatty acids the ratio of AA to eicosapentaenoic acid and the ratio of ω - 6 PUFAs to ω - 3 PUFAs. The external validation results showed that the area under the receiver operating characteristic curve of the Random Forest model Extreme Gradient Boosting model SVM model Classification and Regression Tree model and Logistic Regression model were 0. 927 0. 931 0. 934 0. 84 and 0. 912 respectively. Decision curve analysis indicated that across most probability thresholds the SVM model tended to yield greater net benefit compared to the other models. Conclusion The lung cancer risk prediction model constructed based on the SVM model exhibited the best performance. It can effectively assist medical personnel in early identification of high-risk populations for lung cancer and facilitate precise nutritional interventions targeting risk factors to reduce the incidence of the disease.
2025 Vol. 12 (6): 710-720 [Abstract] ( 48 ) HTML PDF (3788 KB)  ( 102 )
721 Association between nutritional status and functional limitation in elderly patients with colorectal cancer under an endoscopic pathway
Guo Hong, Wang Kaili, Zhang Ying, Zhou Han
Objective To investigate the relationship between nutritional status and functional limitation under the endoscopic care pathway and to clarify the impact of hemoglobin levels and protein intake on functional impairment in elderly colorectal cancer patients providing evidence for peri - endoscopic functional maintenance. Method Data from the NHANES 2005 - 2018 were analyzed. Patients aged ≥60 years with colorectal cancer were included. Hemoglobin levels protein intake and functional limitation were assessed. Restricted cubic spline RCS was used to explore non -linear associations. Logistic and linear regression analyses evaluated the relationship between nutritional exposures and functional limitation risk and severity. Subgroup analyses explored the effects of gender BMI and diabetes. Result A total of 319 patients were included with a functional limitation prevalence of 60. 8%. Functional limitation risk increased significantly when hemoglobin was below 130 g / L or protein intake was below 60 g / d P < 0. 001 . Each 10 g / L increase in hemoglobin reduced functional limitation risk by 34% each 1 g increase in protein intake reduced risk by 2%. Patients with anemia and low protein intake had the highest risk OR = 19. 68 95% CI = 4. 20-92. 17 P < 0. 001 . Subgroup analyses showed stronger associations in males lower BMI and non-diabetic patients. Hemoglobin and protein intake were negatively associated with functional limitation scores. Conclusion Hemoglobin levels and protein intake are protective factors against functional limitation in elderly colorectal cancer patients undergoing endoscopic care. Optimizing nutritional status should be integrated into the endoscopic nursing pathway to enhance perioperative functional reserves.
2025 Vol. 12 (6): 721-729 [Abstract] ( 48 ) HTML PDF (2555 KB)  ( 14 )
730 The predictive value of the pre - treatment hemoglobin albumin lymphocyte and platelet score for the prognosis of radiotherapy in esophageal squamous cell carcinoma
1Zhang Xue,1 Xiao Ling,2 Zheng Xiumei,1Liu Yuxin,3Mu Chunxiao,4 Ni Shuang,2Lyu Jiahua
Objective To investigate the predictive value of the pre-treatment hemoglobin-albumin-lymphocyte-platelet HALP score for overall survival in patients with esophageal squamous cell carcinoma ESCC undergoing radical radiotherapy and to construct a nomogram model to evaluate its predictive performance. Method A retrospective analysis was conducted on 246 patients with stage Ⅲ/ Ⅳ ESCC admitted to Sichuan Cancer Hospital from March 2012 to November 2018. The pre-treatment HALP score was calculated and the optimal cutoff value was determined using X - tile. The correlation between HALP and clinicopathological features was analyzed. Prognostic factors were assessed using the Kaplan-Meier method and Cox regression models. A nomogram was constructed and its predictive performance was validated. Result The low HALP group was significantly associated with more advanced T stage N stage and clinical stage P < 0. 05 . The high HALP group showed significantly better 1- 3- and 5-year overall survival rates compared to the low HALP group 74. 7% vs 54. 0% 46. 6% vs 25. 6% 36. 9% vs 19. 8% P < 0. 001 . Multivariate Cox proportional hazards regression model analysis identified drinking history T stage and HALP as independent prognostic factors for overall survival P < 0. 05 . The nomogram model for predicting overall survival had a C - index of 0. 687 demonstrating good predictive performance and calibration plots indicated high predictive accuracy. Conclusion A low pre-treatment HALP score is an independent poor prognostic factor for overall survival in ESCC patients undergoing radical radiotherapy. The HALP-based nomogram model may provide a reference for individualized prognostic assessment.
2025 Vol. 12 (6): 730-738 [Abstract] ( 52 ) HTML PDF (2952 KB)  ( 14 )
739 Analysis of characteristics of dietary structure changes and risk factors for nutritional status in cervical cancer patients before and after radiotherapy based on the capability opportunity motivation-behavior model
Yu Ya, Zhang Jing, Gui Guan, Yang Yanmei, Yang Yang, Wang Meiming, Wang Shan, Jiang Mengfan
Objective Based on the capability opportunity motivation - behavior COM-B model this study aimed to analyze changes in dietary structure characteristics among patients with cervical cancer before and after radiotherapy and explore factors influencing their nutritional status. Method A total of 200 patients with cervical cancer admitted to the First Affiliated Hospital of Bengbu Medical University between January 2023 and December 2024 were enrolled. Changes in dietary structure before and after radiotherapy were investigated. Patients were divided into a normal nutritional status group n = 114 and an abnormal nutritional status group n = 86 based on the controlling nutritional status CONUT score. Differences in clinical data between the two groups were analyzed and factors influencing nutritional status were explored using the COM - B model. Result The Chinese Dietary Pyramid CHFP score of patients with cervical cancer was 31. 54 ± 4. 57 before radiotherapy and 22. 24 ± 2. 68 after radiotherapy indicating a significant deterioration in dietary structure post - radiotherapy. Multivariate Logistic regression analysis revealed that nutritional knowledge OR= 0. 930 95%CI = 0. 901-0. 959 self-management OR= 0. 952 95%CI = 0. 915-0. 990 payment method OR= 3. 251 95% CI = 1. 372 - 7. 704 monthly household income OR = 4. 195 95% CI = 1. 637 - 10. 746 social support OR = 0. 689 95%CI = 0. 602 - 0. 788 coping style OR = 2. 677 95% CI = 1. 112 - 6. 443 and self - efficacy OR = 0. 963 95% CI = 0. 931-0. 996 were significant influencing factors of nutritional status all P< 0. 05 . The combined indicators showed an AUC of 0. 926 for predicting nutritional status with a sensitivity of 89. 50% and specificity of 86. 80%. Conclusion The dietary structure of patients with cervical cancer is unreasonable. Clinically dietary interventions based on the COM-B model may be implemented to improve their nutritional status.
2025 Vol. 12 (6): 739-746 [Abstract] ( 58 ) HTML PDF (1968 KB)  ( 14 )
747 Assessment of malnutrition in digestive system tumor patients using mPG-SGA PG-SGA and GLIM criteria
1Ji Li,1Zhang Yinghong,1Luo Dan,1Xiao Chunxiu,2Li Dong,3Sun Yu,1Lin Ning
Objective This study aimed to investigate the comparative efficacy of mPG - SGA PG - SGA and GLIM tools in assessing malnutrition among digestive system tumor patients and analyze correlations between mPG-SGA and hematological parameters in newly admitted patients. Method 105 digestive system tumor patients admitted within ≤48 hours to the department of oncology of our hospital between January and April 2025 were enrolled. Demographic data and hematological parameters were collected routinely. Nutritional status was assessed using mPG-SGA PG-SGA and GLIM criteria. Comparative efficacy was analyzed through Spearman correlation between mPG-SGA scores and nutritional biomarkers. Result The mean age of all subjects in this cohort n = 105 was 58. 50±13. 94 years old with male accounted for 67. 62% 71 cases . Prevalence of malnutrition detected by 3 tools was 40. 00% mPG-SGA 43. 81% PG-SGA and 60. 00% GLIM . Using PG-SGA as reference mPG-SGA showed superior sensitivity 100. 00% vs 82. 61% and specificity 93. 65% vs 57. 63% with higher AUC 0. 957 vs 0. 701 . The Kappa coefficients of mPG-SGA vs PG-SGA mPG-SGA vs GLIM and PG-SGA vs GLIM were κ = 0. 922 κ = 0. 432 and κ = 0. 387 respectively all P <0. 001 . Significant positive correlations emerged between mPG-SGA and lymphocytes r = 0. 246 P = 0. 011 hemoglobin r = 0. 226 P= 0. 020 and skeletal muscle index r = 0. 373 P<0. 001 . Conclusion mPG-SGA demonstrated comparable efficacy to PG-SGA and GLIM in malnutrition assessment with correlation with some nutrition indexes.
2025 Vol. 12 (6): 747-753 [Abstract] ( 49 ) HTML PDF (1239 KB)  ( 9 )
754 Distribution law of TCM syndromes and their relationship with immune inflammation in patients with cancer -associated malnutrition a cross-sectional study
1,2Zong Mingtong,1,2Xie Hongting,1,2Zhao Leyi,2Li Qing,1Xue Peng,1Zhu Shijie
Objective To investigate the distribution pattern of Traditional Chinese Medicine TCM syndromes in patients with cancer- associated malnutrition and analyze the correlation between these syndrome types and immune - inflammatory indicators. Method A cross-sectional study was conducted from August 2022 to January 2025 at the Oncology Department of Wangjing Hospital Chinese Academy of Traditional Chinese Medicine. A standardized questionnaire was used to collect general information nutrition impact symptoms physical examination indicators and immune - inflammatory indicators from 191 patients diagnosed with CAM. Descriptive frequency analysis was performed for NIS the distribution of major TCM syndrome types was summarized based on factor analysis and cluster analysis and intergroup difference analysis of immune-inflammatory indicators among different TCM syndrome types in CAM patients was conducted. Result Among the 191 CAM patients xerostomia anorexia and nausea had the highest frequencies of occurrence with 130 126 and 96 cases respectively. Factor analysis of 11 symptoms identified 4 common factors with a cumulative contribution rate of 59. 63%. Results of cluster analysis showed that TCM syndrome types were classified into three categories spleen-stomach yin deficiency syndrome spleen-stomach qi deficiency syndrome and spleen deficiency with dampness accumulation syndrome. Statistically significant differences P<0. 05 were observed in triceps skinfold thickness total protein white blood cells count and systemic immune-inflammation index among the three syndrome types. Secondary analysis revealed that TSF in patients with spleen deficiency with dampness accumulation syndrome was lower than that in patients with spleen-stomach qi deficiency syndrome TP appetite visual analog scale score neutrophils and SII in patients with Spleen-stomach qi deficiency syndrome were higher than those in patients with spleen - stomach yin deficiency syndrome while the PG- SGA score was lower all P< 0. 05 . Conclusion This study found that the main TCM syndrome types in CAM patients are spleen - stomach yin deficiency syndrome spleen-stomach qi deficiency syndrome and spleen deficiency with dampness accumulation syndrome. Patients with spleen-stomach yin deficiency syndrome have the most severe CAM patients with spleen - stomach qi deficiency syndrome present a more severe inflammatory state and patients with spleen deficiency with dampness accumulation syndrome show the most significant reduction in muscle mass. In conclusion for CAM patients TCM treatment should be based on " strengthening the spleen " combined with replenishing qi nourishing yin and resolving dampness to regulate immune-inflammatory levels and improve malnutrition.
2025 Vol. 12 (6): 754-760 [Abstract] ( 51 ) HTML PDF (1072 KB)  ( 7 )
761 Study on the relationship between peripheral blood inflammation-nutritional parameters and pathological characteristics in patients with endometrial cancer based on automatic classifier and its short-term prognostic predictive value
Ma Jingjing, Liu Wenting, Gao Lu, Liu Yanjia
To analyze the relationship between peripheral blood inflammation-nutritional parameters and pathological characteristics of patients with endometrial cancer based on automatic classifiers and its short - term prognostic predictive value. Method A retrospective study included 156 patients with endometrial cancer who underwent surgical treatment in the First Affiliated Hospital of Xinjiang Medical University from April 2020 to April 2024 the experimental group and 110 age-matched healthy women the control group . The fibrinogen - albumin ratio FAR prognostic nutritional index PNI lymphocyte-monocyte ratio LMR and systemic immune inflammation index SII were compared between the two groups. Further analyze the differences of each index under different pathological characteristics FIGO stage grade etc. in the experimental group. Based on the Modeler automatic classifier screen the prognostic influencing factors of patients with endometrial cancer analyze the relationship between peripheral blood inflammation-nutrition parameters and prognosis and explore its predictive value. Result The research results showed that there were significant differences in inflammation and nutritional indicators between the experimental patients and the control group. The FAR 0. 08±0. 02 vs 0. 07±0. 01 and SII 610. 04±90. 86 vs 425. 64±102. 12 of the experimental group were significantly higher than those of the control group P<0. 05 . However PNI 49. 61±8. 05 vs 52. 69±1. 57 and LMR 3. 96±0. 78 vs 4. 35±0. 51 were significantly lower than those of the control group P<0. 05 . Further analysis revealed that patients with positive vascular invasion or nerve invasion had higher FAR and SII than those with negative results and lower PNI and LMR than those with negative results. The FAR and SII of patients in FIGO stage II were significantly lower than those of patients in stage Ⅲ and IV P<0. 05 . Among the prognosis prediction models established through the Modeler algorithm neural networks with an accuracy rate of 96. 15% Bayesian networks 94. 87% and C5 decision trees 94. 23% all demonstrated excellent prediction performance with FAR being the most important predictor. Conclusion The inflammation-nutrition parameters in the peripheral blood of patients with endometrial cancer are significantly correlated with pathological characteristics. The accuracy rate of the prediction model constructed based on Modeler is over 94%. The combination of inflammation - nutrition indicators and pathological characteristics can be used as an effective prognostic evaluation tool.
2025 Vol. 12 (6): 761-770 [Abstract] ( 45 ) HTML PDF (4096 KB)  ( 12 )
771 Expression and clinical significance of TNF-α and ATIC in bone marrow biopsy tissue of patients with multiple myeloma
1Chen Yue,2Bai Shunning,1Ren Qiaowei
Objective To investigate the expression and clinical significance of tumor necrosis factor - α TNF - α and 5 - aminoimidazole-4-carboxamide nucleotide transformylase ATIC in bone marrow biopsy tissues of patients with multiple myeloma MM . Method A total of 90 patients with MM admitted to Yan'an People's Hospital between May 2021 and June 2023 were included in the MM group. Additionally 55 patients with benign haematological disorders admitted during the same period were selected using a random number table method to form the control group. Immunohistochemistry was used to detect TNF-α and ATIC in bone marrow tissue. Spearman ' s rank correlation analysis of the relationship between TNF - α expression and ATIC in MM organisations. Kaplan-Meier curve was used to analyze the relationship between TNF - α ATIC and prognosis. The Cox proportional hazards regression model was employed to analyse the prognostic factors influencing patients with MM. Result For the control group the MM group had a higher positive rate of TNF-α and ATIC proteins in bone marrow tissue P<0. 05 . The positive expression of TNF-α and ATIC was associated with the international staging system ISS P>0. 05 . Spearman's rank correlation analysis revealed a positive correlation between TNF-α expression in MM tissue and ATIC r = 0. 374 P<0. 001 . Survival curves showed that the 3-year survival rate of patients in the TNF-α ATIC positive expression group was lower than that of patients in the negative expression group P< 0. 05 . Univariate Cox regression showed that ISS stage Ⅲ TNF-α positivity and ATIC positivity were associated with mortality in MM P<0. 05 . Multivariate Cox proportional hazards regression analysis revealed that TNF-α positivity and ATIC positivity constitute risk factors for mortality in MM patients P<0. 05 . The AUC values of TNF-αand ATIC in bone marrow tissues of the MM group for predicting the prognosis of MM patients were 0. 640 95% CI = 0. 523-0. 756 and 0. 714 95% CI = 0. 604-0. 824 with a sensitivity of 67. 57% and 72. 97% respectively and a specificity of 60. 38% and 69. 81% respectively. The Hosmer - Lemeshow goodness-of-fit test showed that the ISS staging TNF-α and ATIC models fitted better χ 2 = 3. 061 P = 0. 216 . Conclusion The positive expression rates of TNF-α and ATIC in the bone marrow tissue of MM patients are relatively high both serving as prognostic factors for MM patients.
2025 Vol. 12 (6): 771-778 [Abstract] ( 49 ) HTML PDF (3351 KB)  ( 15 )
779 Efficacy evaluation of medical tissue adhesive combined with microwave ablation in interventional treatment of peripheral lung cancer
Wang Kui, Tan Yonghua, Liang Guangcong
Objective Exploring the efficacy evaluation of medical tissue glue combined with microwave ablation in the treatment of peripheral lung cancer. Method A prospective study design was adopted. A total of 105 patients with peripheral lung cancer who met the inclusion criteria and were admitted to Bayingolin Mongolian Autonomous Prefecture People 's Hospital from January 2021 to December 2023 were selected. They were divided into an observation group n = 53 and a control group n = 52 using a random number table method. The control group was treated with microwave ablation while the observation group was treated with microwave ablation combined with medical tissue glue. The clinical efficacy of the two groups was compared after 3 years of follow-up the survival rate and recurrence rate of the two groups were statistically analyzed the Cox proportional hazards regression model was used to analyze the prognostic factors and the quality of life and incidence of complications of the two groups were compared. Result After 1 month of treatment the complete ablation rate disease control rate DCR and objective response rate ORR in the observation group were significantly higher than those in the control group P <0. 05 . After 3 years of follow-up the overall survival OS and progression-free survival PFS in the observation group were higher than those in the control group while the local recurrence rate was lower than that in the control group P <0. 05 . Cox regression analysis showed that combined treatment and tumor diameter ≤3 cm were independent protective factors for OS. Stratified analysis showed that the combined therapy had a more significant therapeutic effect on patients with tumor diameter ≤3 cm P <0. 05 . After 3 months of treatment the quality of life score in the observation group was higher than that in the control group P <0. 05 . The total incidence of complications in the observation group was lower than that in the control group and no severe complications occurred. Conclusion The combination of medical tissue glue and microwave ablation in the interventional treatment of peripheral lung cancer has better efficacy than microwave ablation alone. It can reduce the recurrence rate of patients improve their 3-year survival rate.
2025 Vol. 12 (6): 779-785 [Abstract] ( 57 ) HTML PDF (1223 KB)  ( 31 )
786 The expression of serum FGFR2 and CCN1 in patients with multiple myeloma and their relationship with prognosis
1Liu Fang,1Wang Ningfang,1You Yueming,1Zhang Dongdong,1Cai Zhuowen,1Cai Fangfang,2Zhao Penghao
Objective To discuss the correlation between serum fibroblast growth factor receptor 2 FGFR2 cellular communication network 1 CCN1 and prognosis in patients with multiple myeloma MM . Method A total of 104 newly diagnosed MM patients who received treatment in Hebei PetroChina Central Hospital from September 2020 to January 2022 were selected as the study group and 106 healthy people of the same age who passed the health examination test in our hospital were selected as the control group. According to the follow-up results of prognosis patients in the study group were classified into a survival group of 62 cases and a death group of 42 cases. ELISA method was used to detect the serum FGFR2 and CCN1 in patients. Pearson analysis analyzed the correlation between serum FGFR2 and CCN1 levels and age and ISS stage of patients. The risk factors of death in MM patients were analyzed by multivariate Cox regression. ROC curves were used to analyze the diagnostic value of serum FGFR2 and CCN1 levels in the mortality of MM patients. The Kaplan-Meier method was used to analyze the relationship between serum FGFR2 and CCN1 levels and the three-year survival rate of MM patients. Result For the control group the study group had clearly higher serum FGFR2 and clearly higher CCN1 P< 0. 05 . For the survival group the death group had clearly higher serum FGFR2 and clearly higher CCN1 P< 0. 05 . The differences in age and ISS staging between the survival group and the death group were statistically clear P< 0. 05 . Serum FGFR2 level was positively correlated with ISS stage and serum CCN1 level was negatively correlated with ISS stage P< 0. 05 . FGFR2 CCN1 age and ISS stage were independent risk factors for mortality in patients with MM P<0. 05 . The joint of serum FGFR2 and CCN1 had an AUC of 0. 953 for diagnosing death in MM patients. The joint diagnosis was superior to individual diagnosis Z= 3. 513 3. 237 P< 0. 05 . The three-year survival rate of patients with high serum FGFR2 was lower than that of patients with low serum FGFR2 and the three-year survival rate of patients with low serum CCN1 was lower than that of patients with high serum CCN1 P < 0. 05 . Conclusion Serum FGFR2 is upregulated and CCN1 is downregulated in MM patients they are associated with prognosis. The joint of the two has certain value in diagnosing the death of MM patients.
2025 Vol. 12 (6): 786-793 [Abstract] ( 47 ) HTML PDF (3627 KB)  ( 14 )
794 A nutritional index-derived prognostic risk model for postoperative gastric cancer patients development and performance evaluation
Li Xue, Zhang Jianjun, Ji Meihong, Zhang Dan, Wang Wentao, Zhang Lan
Objective This study aims to construct and validate a nomogram for predicting postoperative survival probability in patients with gastric cancer. Method A retrospective analysis was conducted on 370 patients diagnosed with gastric cancer who underwent radical surgery at Liaoning Cancer Hospital between January 2017 and May 2021. Stratified sampling method was used to divide the data into a training cohort n = 246 and a validation cohort n = 124 at a 2 ∶ 1 ratio. Clinical data including baseline characteristics prognostic nutritional index PNI pathological features inflammatory factors and tumor markers were collected as candidate variables. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify independent risk factors associated with postoperative survival dependent variables . Subsequently a nomogram prediction model was developed based on these identified factors. The performance of the nomogram—including its accuracy and discriminative ability—was evaluated using the area under the receiver operating characteristic curve AUC calibration curves and compared against that of the traditional TNM staging system. Additionally decision curve analysis DCA and Kaplan-Meier survival curves were employed to further assess its clinical utility. Result Cox regression analyses identified four independent prognostic factors PNI lymph node metastasis depth of invasion and CA125 levels. These factors were incorporated into the nomogram for visual representation of survival predictions. The nomogram demonstrated significantly superior prognostic performance compared to traditional TNM staging this was evidenced by higher AUC values improved calibration through calibration plots and greater net clinical benefit as determined by DCA. Conclusion The nomogram incorporating nutritional indicators—including PNI—can accurately predict postoperative survival in patients with gastric cancer thereby providing a reliable tool for personalized clinical decision-making.
2025 Vol. 12 (6): 794-804 [Abstract] ( 58 ) HTML PDF (5362 KB)  ( 12 )
805 Construction of a prediction model for postoperative recurrence and metastasis based on the temporal changes of serum NT-3 CDH3 and PDHA1 in colorectal cancer
1Li Ying, 1Song Zhigang, 2Dong Huaxing, 3Liu Shuai, 1Lian Yanjun
Objective To investigate the temporal changes in serum neurotrophin-3 NT-3 cadherin-3 CDH3 and pyruvate dehydrogenase E1α subunit PDHA1 after radical surgery in colorectal cancer CRC patients and to construct a dynamic multi-index prediction model for postoperative recurrence and metastasis. Method A prospective cohort of 108 CRC patients who underwent radical resection in the Department of Gastrointestinal Surgery from June 2021 to June 2022 was enrolled. Serum samples were collected preoperatively and at 6 12 24 and 36 months postoperatively. Follow-up ended in June 2025. Recurrence and metastasis events were recorded and prediction models were constructed. Result Dynamic monitoring of 108 postoperative CRC patients revealed that the recurrence group had higher rates of vascular invasion and perineural invasion P < 0. 05 a higher proportion of TNM stage Ⅲ and ≥ 3 lymph node metastases P = 0. 008 and elevated serum biomarker levels compared to the non-recurrence group NT-3 at 6 months 25. 30 ng / ml vs 21. 70 ng / ml P = 0. 018 and 12 months 30. 50 ng / ml vs 20. 80 ng / ml P = 0. 004 CDH3 at 12 months 22. 90 pg / ml vs 17. 50 pg / ml P = 0. 010 and PDHA1 at 12 months 11. 30 ng / L vs 8. 00 ng / L P = 0. 003 . Univariate analysis confirmed that postoperative NT - 3 CDH3 and PDHA1 levels and clinical stage were independent predictors of recurrence. The random survival forest model constructed based on these factors showed excellent predictive performance AUC = 0. 853 significantly outperforming the traditional TNM staging model AUC = 0. 671 and the Cox model AUC = 0. 789 with strong clinical utility. Conclusion The temporal dynamic changes in serum NT-3 CDH3 and PDHA1 can serve as effective predictive indicators for postoperative recurrence and metastasis in CRC. The RSF model incorporating multi - timepoint detection significantly improves predictive accuracy.
2025 Vol. 12 (6): 805-813 [Abstract] ( 53 ) HTML PDF (2092 KB)  ( 9 )
814 Clinical application of probiotics combined with low-GI high-quality protein diet in regulating muscle and fat metabolism in obese patients
1Lin Bing, 1Yang Jing, 1 2Zhu Cuifeng
Objective To explore the effects and analysis of probiotics combined with low glycemic index GI and high-quality protein diet intervention on muscle mass fat mass and grip strength in obese patients. Method A total of 110 obese patients who attended the Department of Clinical Nutrition Shenzhen Hospital of Southern Medical University from July to December 2024 were selected and randomly divided into an intervention group n = 55 and a control group n = 55 using the random number table method. All obese patients received an individualized low GI and high-quality protein diet which includes an energy intake of 20 kcal / kg·d energy ratio of 30% for protein 40% for carbohydrates and 30% for fat and dietary fiber intake of 14 g / d. The intervention group was given an additional probiotic preparation besides the dietary intervention for 8 weeks. The changes of body weight and body composition after the intervention were compared. All gastrointestinal adverse reactions were recorded. Result There was no significantly difference in body weight body mass index muscle mass and grip strength between the two groups at the baseline P > 0. 05 . After the intervention the body weight of both groups decreased P<0. 05 . The weight loss of the intervention group was -6. 14±4. 00 kg which was higher than that of the control group -4. 43±3. 19 kg P<0. 05 . Moreover the muscle loss in the intervention group was less than that in control group - 1. 35± 1. 48 kg vs - 2. 31± 1. 74 kg P < 0. 05 while the fat loss was greater. The analysis of both male and female subgroups showed a consistent muscle protection effect. Especially after the intervention the grip strength of females was significantly greater than that of control group P = 0. 032 . Probiotics can reduce the incidence of constipation during the intervention P = 0. 031 and there are no other serious adverse events. Conclusion The intervention of probiotics combined with a low-GI and high-quality protein diet can effectively reduce the weight body fat mass of obese patients and may protect the muscles and strength during the weight loss process through the gut-muscle axis.
2025 Vol. 12 (6): 814-819 [Abstract] ( 43 ) HTML PDF (895 KB)  ( 16 )
820 Clinical value of 192 Ir paracervical boost radiotherapy in locally advanced cervical cancer
Chang Shichuan, Huang Xiaoping, Zhang Bujuan, Mao Weiling, Lu Man
Objective To explore the application value of 192 Ir interstitial implantation paracervical boost radiotherapy in the treatment of locally advanced cervical cancer LACC . Method A prospective randomized controlled study enrolled 104 LACC patients from August 2023 to February 2025 who were randomized at a 2 ∶ 1 ratio using a random number table method into an experimental group n = 69 and a control group n = 35 . Finally 96 patients completed the treatment and follow-up 64 in the experimental group and 32 in the control group . Both groups received pelvic external beam radiotherapy combined with concurrent chemotherapy. The experimental group was additionally treated with 192 Ir interstitial implantation paracervical boost radiotherapy while the control group received conventional intracavitary brachytherapy ICBT . The two groups were compared in terms of target volume dosimetric parameters radiation doses to organs at risk short - term therapeutic efficacy Karnofsky performance score KPS nutritional indicators serum albumin prealbumin body weight change and adverse reactions. Result In the experimental group the D90 dose covering 90% of the target volume of the high-risk clinical target volume HR-CTV was 86. 2±5. 3 Gy which was higher than that of the control group 83. 5±3. 2 Gy the conformity index CI was 0. 85±0. 06 which was higher than that of the control group 0. 76±0. 05 and the homogeneity index HI was 0. 15±0. 04 which was lower than that of the control group 0. 23±0. 05 all P<0. 05 . The D2cc dose to 2 cm 3 of the organ of the rectum 70. 3±4. 2 Gy and bladder 71. 5±3. 9 Gy in the experimental group were lower than those in the control group both P<0. 05 . One month after treatment the complete response CR rate in the experimental group 76. 56% was higher than that in the control group P<0. 05 . Three months after treatment the improvement rate of KPS 45. 3% serum albumin level 38. 5±3. 2 g / L and prealbumin level 235. 6±28. 4 mg / L in the experimental group were all higher than those in the control group whereas the rate of weight loss 12. 5% proportion of patients with PG-SGA grade C 6. 2% and incidence of rectal toxicity 42. 19% were lower than those in the control group all P < 0. 05 . Conclusion 192 Ir interstitial implantation paracervical boost radiotherapy can optimize the target volume dose distribution in LACC patients improve tumor control rate enhance short-term quality of life and nutritional status without increasing the incidence of severe acute-phase adverse reactions.
2025 Vol. 12 (6): 820-826 [Abstract] ( 53 ) HTML PDF (937 KB)  ( 8 )
827 Icaritin affects STAT 3 - mediated macrophage polarization via hepatocellular carcinoma cells - delivered exosome an in vitro research
1Zheng Xia,2Xun Chen,2Qu Wenshu
Objective To explore the pharmacological effect of acodarin an extract from the Chinese herbal medicine Epimedium in regulating signal transducer and activator of transcription 3 STAT3 -mediated macrophage polarization via exosomes derived from hepatocellular carcinoma HCC cells. Method HepG2 cell line was administrated by Icaritin 10 μmol / L or DMSO in vitro and then was cocultured with THP-1 cell-derived macrophage in a Transwell coculture system. The levels of IL-6 and TGF-β secreted by the macrophage were detected by ELISA assay. Flow cytometry was utilized to examine CD206 expression which is a biomarker of M2 macrophage. We extracted and identified the exosomes derived from DMSO or Icaritin-treated HepG2 cells. ELISA assay was utilized to detect IL-6 and TGF-β expressed in macrophage after administrated with exosomes isolated from HCC cells with or without Icaritin treatment. The expression and activity of STAT3 were assessed by Western blot assay. Result the expression of IL-6 TGF-β and CD206 were increased after cocultured with HCC cells but decreased significantly after cocultured with Icaritin - induced HepG2 cells. Meanwhile Icaritin-induced exosome also inhibited the expression of IL-6 and TGF-β as well as STAT3 activity. Conclusion Icaritin can inhibit macrophage polarize to M2 via HCC cells-derived exosomes. These findings indicate that Icaritin was an immune regulator in HCC microenvironment.
2025 Vol. 12 (6): 827-832 [Abstract] ( 49 ) HTML PDF (3358 KB)  ( 9 )
Copyright © Editorial Board of Electron J Metab Nutr Cancer
Supported by:Beijing Magtech