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| The clinical value of fat - free mass index for the assessment of nutritional status and prognosis in non - metastatic
nasopharyngeal carcinoma patients |
| 1Zhang Beilei,1Lu Yingying,2Shi Xiaowei |
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Abstract Objective This study aimed to explore the role of fat-free mass index FFMI measured by bioelectrical impedance
analysis BIA for nutritional and prognostic assessment of non - metastatic nasopharyngeal carcinoma patients. Method This
retrospective study collected clinicopathological data of 162 nasopharyngeal carcinoma patients who received systematic treatment in
Hai'an People's Hospital From January 2019 to June 2022 and FFMI was measured and calculated by BIA. All patients were divided
into low FFMI n = 55 and normal FFMI group n = 107 according to its threshold recommended by Asian Working Group of Sarcopenia
male FFMI <17 kg / m
2
female FFMI <15 kg / m
2
. The baseline characteristics and progression-free survival PFS of the two
groups were compared. Kaplan-Meier curves and the Cox proportional regression model were used to evaluate the relationship between
FFMI and the prognosis of nasopharyngeal carcinoma patients. Result The mean FFMI of the entire cohort was 17. 8 ± 2. 0 kg / m
2
. Of
them 34. 0% 55 / 162 were diagnosed as low FFMI. The patients with low FFMI had a lower BMI t = 5. 168 P<0. 001 and higher
risk of malnutrition NRS 2002≥ 3 points
χ
2 = 5. 817 P = 0. 015 than those with normal FFMI. With regard to nutrition-related
parameters the level of serum albumin t = 2. 032 P= 0. 044 lymphocyte count t = 2. 674 P= 0. 008 mid-arm circumference t =
3. 850 P<0. 001 and handgrip strength t = 2. 229 P= 0. 027 in patients with low FFMI were significantly lower than in those with
normal FFMI. The Kaplan - Meier curve showed that low FFMI was correlated with poor prognosis of nasopharyngeal carcinoma
patients. The 3-year PFS rates of patients with low and normal FFMI were 45. 6% and 68. 4% respectively
χ
2 = 7. 957 P= 0. 005 .
The univariate and multivariate Cox regression analysis revealed that TNM stage HR= 3. 393 95%CI = 1. 911-6. 023 P<0. 001 and FFMI HR = 2. 182 95% CI = 1. 242 - 3. 831 P = 0. 007 were independent predictor of PFS for nasopharyngeal carcinoma
patients. Conclusion The FFMI measured by body composition analysis had important clinical significance for nasopharyngeal
carcinoma patients and it might be a useful parameter for nutritional and prognostic assessment.
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| Cite this article: |
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1Zhang Beilei,1Lu Yingying,2Shi Xiaowei. The clinical value of fat - free mass index for the assessment of nutritional status and prognosis in non - metastatic
nasopharyngeal carcinoma patients[J]. Electron J Metab Nutr Cancer, 2025, 12(2): 238-244.
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| URL: |
| http://www.ejmnc.com//EN/ OR http://www.ejmnc.com//EN/Y2025/V12/I2/238 |
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