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| Clinical expert consensus on the diagnosis and treatment of sarcopenic obesity |
| Chinese Society of Nutritional Oncology, Chinese Society for Holistic Integrative Supportive Care |
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Abstract Sarcopenic obesity SO is a complex condition characterized by the coexistence of sarcopenia and obesity commonly
seen in older adults and individuals with chronic diseases including malignancies. SO is associated with a markedly increased risk of
poor clinical outcomes including diminished quality of life reduced physical function and elevated mortality. Accurate diagnosis and
effective management are essential to mitigating these risks and improving patient outcomes. Based on current research and clinical
experience this paper uses the GRADE system Grading of Recommendations Assessment Development and Evaluation to grade the
evidence quality and recommendation strength of recommendations related to SO clinical screening diagnosis evaluation and
treatment to form a consensus. The guidelines advocate for a stepwise diagnostic approach integrating assessments of skeletal muscle
function and body composition and the specific diagnostic thresholds for the China population should be used to ensure the accuracy of
diagnosis. Treatment recommendations encompass pharmacological therapies nutritional interventions and exercise programs and
these interventions should be individually adjusted according to the patient's specific needs and condition. These guidelines aim to
equip clinicians with a standardized framework to optimize the management of SO and enhance patient care.
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