Relationships between ketogenic diet and metabolic associated fatty liver disease
1Hu Yanfang ,1Wang Jian ,2Meng Qinghua
1Department of Hepatopathy The Third General Hospital of Taiyuan Taiyuan 030000 Shanxi China
2Department of Medical
Oncology Beijing You'an Hospital Capital Medical University Beijing 100069 China
Abstract：With lifestyle changes metabolism-related fatty liver disease MAFLD accounts for a gradual increase in chronic liver
disease affecting 25% of adults worldwide and being thought to be co-present with other chronic liver diseases. MAFLD is not only
closely related to the occurrence and development of chronic hepatitis cirrhosis hepatocellular carcinoma but also considered as a
cause and effect with obesity and type 2 diabetes. Besides it also promotes the onset of hypothyroidism metabolic syndrome
cardiovascular disease and malignant tumors. Given the fact that there is currently no specific drug for treatment adopting a healthy
lifestyle and weight loss are key to the prevention and treatment of MAFLD and its comorbidities. The ketogenic diet is a therapeutic
diet with low carbohydrate high fat and appropriate protein that converts the body's energy supply from glucose to fat mobilization
which in turn produces the energy supply mode of ketone bodies. Based on this theoretical basis ketogenic diet is considered to have
the potential to reduce body mass improve insulin resistance regulate glycolipid metabolism. And the effect of it as the adjuvant
treatment for diabetes mellitus type 2 and obesity has been verified in many animal models and clinical trials. Still the clinical
application of ketogenic diet in MAFLD is mostly short-term research and the relationship between the two is still in the exploration
stage. This article reviews the research reports on how ketogenic diets reduce body mass and improve insulin resistance in patients with
MAFLD.
