1Department of Clinic Nutrition Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing
210008 Jiangsu China
2Department of Clinic Nutrition Gangcheng Rehabilitation Hospital of Zhangjiagang Suzhou 215600
Jiangsu China
3Department of Ultrasound Diagnosis Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical
School Nanjing 210008 Jiangsu China
4Department of Public Health Xuzhou Medical University Xuzhou 221004 Jiangsu China
Abstract：In recent years the number of cancer patients in the world has risen sharply and the medical and economic burden
caused by cancer cachexia and its related complications has also increased dramatically. Cancer cachexia is a complex multifactorial
syndrome characterized by progressive loss of skeletal muscle and associated with multiple organ dysfunction which could not be
completely reversed by conventional nutritional therapy. Cardiac complications associated with cancer cachexia include cardiac atrophy
remodeling dysfunction and even heart failure. Cancer cachexia - induced cardiac atrophy is mainly as a result of interactions
between cachexia mediators and the ubiquitin-proteasome pathway. Activation of the ubiquitin-proteasome system UPS decreases
cardiac protein synthesis and inflammation accelerates the process of myocardial atrophy at the same time insulin resistance leads to
the depletion of stored proteins and hinders the uptake and utilization of nutrients by tissues and cells. It is an early complication of the
cardiovascular system in patients with cancer cachexia which is often ignored or confused with the primary heart disease. Failure to
diagnosis and treatment cardiac atrophy in time will not only aggravate severe cachexia but also reduce the curative effect of anticancer treatment. Therefore scientific diagnosis and treatment of cancer related cardiac atrophy can help improve the curative effect of
anti-cancer treatment and thus improve the survival rate of cancer patients. Therefore the early screening diagnosis and treatment of
cancerous cachexia related cardiac atrophy is of great significance for tumor treatment.
