Progress review on tumor metabolic reprogramming and nutritional modulation therapy
Metabolic reprogramming, as one of the hallmarks of cancer, is widely observed in almost all tumorigenesis and development processes. Tumor cells meet their needs for bioenergy, biosynthesis, and redox balance by reprogramming nutrient acquisition and metabolism. In view of the key role of metabolic changes in tumorigenesis and development, targeting tumor metabolism has become one of the hottest topics in cancer drug development worldwide. In recent years, restriction of tumor metabolism by specific nutritional modulation has been widely studied and considered for clinical application. This approach, without impairing nutritional requirement for normal organs, restricts patients from specific nutrition that are essential for metabolic reprogramming in tumor cells. Nutritional modulation may sensitizes cells to chemotherapy, thus sheds light on efficient outcome of combined therapy strategy. This review will summarize the important tumor metabolic reprogramming events discovered in recent years. The progression of nutritional modulation treatments and preclinical and preliminary clinical experimental foundations of dietary and metabolic interventions in cancer therapy will be discussed.
Abstract：Metabolic reprogramming, as one of the hallmarks of cancer, is widely observed in almost all tumorigenesis and development processes. Tumor cells meet their needs for bioenergy, biosynthesis, and redox balance by reprogramming nutrient acquisition and metabolism. In view of the key role of metabolic changes in tumorigenesis and development, targeting tumor metabolism has become one of the hottest topics in cancer drug development worldwide. In recent years, restriction of tumor metabolism by specific nutritional modulation has been widely studied and considered for clinical application. This approach, without impairing nutritional requirement for normal organs, restricts patients from specific nutrition that are essential for metabolic reprogramming in tumor cells. Nutritional modulation may sensitizes cells to chemotherapy, thus sheds light on efficient outcome of combined therapy strategy. This review will summarize the important tumor metabolic reprogramming events discovered in recent years. The progression of nutritional modulation treatments and preclinical and preliminary clinical experimental foundations of dietary and metabolic interventions in cancer therapy will be discussed.
