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肿瘤代谢与营养电子杂志
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肿瘤代谢重编程与营养调节对肿瘤的影响
代谢重编程是肿瘤的重要特征之一,几乎在所有的肿瘤发生、发展过程中都会被观察到。肿瘤细胞通过重编程营养物质的获取和代谢方式,来满足其对能量、生物大分子合成以及维持氧化还原平衡的需求。由于代谢重编程在肿瘤发生和发展中起到重要作用,靶向肿瘤代谢已经成为国际上抗肿瘤药物研发的热点之一。近年来,以限制特定肿瘤代谢过程为目标的营养调节作为一种新的干预手段开始被临床试验所重视,该治疗方法利用限制肿瘤特定营养来实现一系列的生物学效应,在维持正常的细胞、器官和系统功能的前提下,促进肿瘤细胞对化疗药物的敏感性。本文将对肿瘤代谢重编程在近年来的一些重要进展进行总结,也将讨论营养调节治疗的当前进展,综合讨论饮食和代谢干预在肿瘤治疗中的作用,并提供临床前和初步临床试验依据。
Progress review on tumor metabolic reprogramming and nutritional modulation therapy
Metabolic reprogramming, as one of the hallmarks of cancer, is widely observed in almost all tumorigenesis and development processes. Tumor cells meet their needs for bioenergy, biosynthesis, and redox balance by reprogramming nutrient acquisition and metabolism. In view of the key role of metabolic changes in tumorigenesis and development, targeting tumor metabolism has become one of the hottest topics in cancer drug development worldwide. In recent years, restriction of tumor metabolism by specific nutritional modulation has been widely studied and considered for clinical application. This approach, without impairing nutritional requirement for normal organs, restricts patients from specific nutrition that are essential for metabolic reprogramming in tumor cells. Nutritional modulation may sensitizes cells to chemotherapy, thus sheds light on efficient outcome of combined therapy strategy. This review will summarize the important tumor metabolic reprogramming events discovered in recent years. The progression of nutritional modulation treatments and preclinical and preliminary clinical experimental foundations of dietary and metabolic interventions in cancer therapy will be discussed.