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2016 Vol. 3, No. 3
Published: 2016-09-02
 
131 Do cancer patients need dietary restriction?
Do cancer patients need dietary restriction?
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.001
2016 Vol. 3 (3): 131-134 [Abstract] ( 235 ) HTML PDF (1213 KB)  ( 240 )
135 Vitamin C in cancer treatment
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.002
2016 Vol. 3 (3): 135-138 [Abstract] ( 211 ) HTML PDF (1428 KB)  ( 250 )
139 Antioxidants in cancer prevention and treatment
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.003
2016 Vol. 3 (3): 139-142 [Abstract] ( 196 ) HTML PDF (2350 KB)  ( 219 )
144 Anti-inflammatory therapy for cancer
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.004
2016 Vol. 3 (3): 144-148 [Abstract] ( 228 ) HTML PDF (1056 KB)  ( 222 )
149 Mineral metabolic therapy for cancer
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.005
2016 Vol. 3 (3): 149-154 [Abstract] ( 227 ) HTML PDF (1063 KB)  ( 247 )
155 Clinical connection with applied physiology of stomach
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.006
2016 Vol. 3 (3): 155-157 [Abstract] ( 177 ) HTML PDF (1213 KB)  ( 229 )
158 Nutritional therapy Guidelines for chemotherapy
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.007
2016 Vol. 3 (3): 158-163 [Abstract] ( 466 ) HTML PDF (855 KB)  ( 190 )
164 Nutritional therapy Guidelines for colorectal cancer
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.008
2016 Vol. 3 (3): 164-165 [Abstract] ( 334 ) HTML PDF (763 KB)  ( 152 )
166 Nutritional status of patients with tumor and its effect on clinical outcomes
HE Fang;WANG Lei-lei;MENG Xue-shan;WU Yue;YE Li-jia;ZHANG Pian-hong
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.010
Abstract: Objective The aim of this study was to understand the nutritional status in patients with tumor and evaluate the
impact of malnutrition on clinical outcomes, then provide scientific reference for nutritional support of patients. Methods 802
patients were admitted in the period of 2014.06 to 2014.08 in 12 hospitals in Zhejiang Province. The rate of nutritional risk and
malnutrition was evaluated with nutrition risk screening 2002 (NRS 2002) and 2015 ESPEN diagnostic criteria, biochemical
indexes and nutrition therapy were recorded. Results The incidence rate of nutrition risk was 31.8% and malnutrition was 17.7%
and gastrointestinal tumor was higher than others. Weight and BMI were significantly lower in gastrointestinal tumor patients
than in non-gastrointestinal tumor patients (P<0.05); The ratio of nutrition therapy in the group of NRS 2002≥3 was 28.24%, and
6.4% in NRS 2002<3 (χ2=71.809, P<0.01). Nutrition therapy with malnutrition was 26.06% and 10.61% in well-nourished patients
(χ2=28.235, P<0.01). Patients at nutritional risk according to NRS 2002 （score≥3）prolonged hospitalization days and costs (P<0.01).
It’s the same as malnutrition except costs. Patients with malnutrition had no difference in the length of ICU and hospitalization
costs.
2016 Vol. 3 (3): 166-169 [Abstract] ( 336 ) HTML PDF (940 KB)  ( 228 )
170 The correlation between prealbumin levels and PG-SGA score in patients with advanced gastric cancer
SUN Fang-yuan, ZHANG Bei-lei, ZHANG Yan-zhong
Abstract: Objective To probe a more scientific nutritional assessment tool for patients with advanced gastric carcinoma by comparing and analyzing the relationship between PA levels and PG-SGA score. Methods 72 patients with advanced gastric carcinoma and suitable for radical resection were enrolled in this study by the Department of General Surgery in Shanxi People's Hospital from May 1, 2015 to May 1, 2016. PG-SGA was applied for nutritional status evaluation, venous serum PA levels was measured for protein level, and the Spearman correlation coefficient method was used to analyze the correlation between PA levels and PG-SGA score. Results Among the 72 advanced gastric carcinoma patients, 48 cases (67%) were in malnutrition (PG-SGA≥4) with a PA levels at 152.57±46.95mg/L, significantly lower than the non-malnutrition group (252.68±44.31mg/L, P<0.001); The higher PA levels was, the lower PG-SGA score got, the cut-point PA levels was 186.82mg/L when the PG-SGA score was equal/ higher than 4 points (P<0.001). Conclusions The incidence of malnutrition in patients with advanced gastric carcinoma was high; the results of this study confirmed that PA levels and PG-SGA score had a negative correlation, when the PA levels was lower than 186.82mg/L, the patients were malnourished. The combination of PA levels and PG-SGA score could provide comprehensive assessment of the nutritional status for patients with advanced gastric carcinoma.
2016 Vol. 3 (3): 170-173 [Abstract] ( 322 ) HTML PDF (915 KB)  ( 255 )
174 The clinical effect of Shengbai Guben granule in advanced cancer patients
ZENG Ya-qi;LIU Wei-shuai;WANG Kun
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.012
Abstract: Objective The aim of this study was to discuss whether Shengbai Guben granule can improve the nutritional status and the degree of fatigue in advanced cancer patients. Methods From February 24, 2015 to June 18, 2016, 37 patients who received pain management and oral Shengbai Guben granule therapy more than 2 weeks were observed. The change of nutritional status and the degree of fatigue were evaluated by BFI-C, MFI, PG-SGA, albumin level, grip strength, and daily intake. Results The mean score of the degree of BFI-C before treatment was 4.57 and the score was 2.26 after treatment, the score has significant difference
(P=0.001). Similarly, the score of the effect of BFI-C after treatment were significant lower than pre-treatment (P=0.001). The score of MFI mental fatigue (P=0.001), brain fatigue (P=0.003) after treatment were also lower than pre-treatment. The PG-SGA score after treatment was also lower than pre-treatment (10.54 versus 12.17, P=0.001). The mean energy intake before treatment and after treatment has significant difference (P=0.000). Conclusions Oral Shengbai Guben granule can relief the degree of fatigue, and increase the energy intake and improve the nutritional status, however, it needs further study.
2016 Vol. 3 (3): 174-177 [Abstract] ( 327 ) HTML PDF (879 KB)  ( 202 )
178 The computation biology analysis protocol of next-generation high-throughput RNA-sequencing data from human colon cancer
WANG Wen-yuan;JIANG Hua;PAN Hai-xia;YANG Hao;PENG Jin;ZHOU Zhi-yuan
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.013
Abstract: Objective To introduce an application of the next-generation high-throughput RNA-sequencing (RNA-seq) technology on transcriptomes and gene expression profiles research, based on the RNA-seq data from human colon cancer. Methods Based on the open-source analysis software of Linux platform and RNA-seq data from human colon cancer tissue, the complete workflow of RNA-seq data processing and analysis protocol would be established. And the software selection, quality control and downstream analysis in this workflow would be discussed. Results By using the mainstream RNA-seq computation biology techniques, a set of free and open-source RNA-seq data processing and analysis computational biology protocol have been established. And there were several difference-expressed genes were identified from this human colon cancer RNA-seq data analysis workflow. Conclusions This study provided an easy-to-use protocol for RNA-seq data clean, computation modeling and analysis. As an example of clinical oncology research, it could be referenced for the clinical investigators working on similar study.
2016 Vol. 3 (3): 178-183 [Abstract] ( 338 ) HTML PDF (1558 KB)  ( 213 )
186 The methylation of gene in mTOR pathway and tumor energy metabolism
LI Jie-ru;MA Huai-xing;LI Su-yi
DOI: DOI：10.16689/j.cnki.cn11-9349/r.2016.03.014
Abstract: Stimulated by growth factors, hormone and other signals, mTOR plays a critical role in regulating cell proliferation
and differentiation. We reviewed and analyzed literatures, then argued that the methylation of key genes in mTOR signaling pathway
could result in abnormal energy metabolism in cancer, producing aerobic glycolysis, and interfering with protein hydrolysis.
Demethylating genes in mTOR signaling pathway, which might be an entry point to reverse the abnormal energy metabolism in
cancer.
2016 Vol. 3 (3): 186-190 [Abstract] ( 296 ) HTML PDF (918 KB)  ( 206 )
191 The mechanism of anti-tumor for ketogenic diet
QU Qian-nuo;RAO Ben-qiang;SHI Han-ping
Abstract: Ketogenic diet was a diet combination used primarily to treat epilepsy. With the high prevalence of chronic metabolic diseases and rapid social development, researchers began to focus on the relationship between KD and metabolic syndrome.Metabolic disorder is one of the main biological characteristics of cancer, and “Warburg effect” is the core of the reprogramming of cancer metabolism, resulting in increasing attention on KD with the ability of regulating glycometabolism. This reviwew demonstrated the antineoplastic mechanism of KD, including reducing glucose supply, decreasing the insulin and IGF-1, improving the immune response inhibition, regulating the mTOR pathway, increasing oxidative stress of tumor cells, controlling inflammatory reactions and regulating the function of mitochondria, which provided theoretical basis for application of KD to the cancer treatment in the future.
2016 Vol. 3 (3): 191-194 [Abstract] ( 292 ) HTML PDF (1375 KB)  ( 248 )
195 Yogurt, probiotics and cancer
ZHAO Hong;ZHUANG Ya-fei;LU Shan;ZHOU Fu-xiang
DOI: 10.16689/j.cnki.cn11-9349/r.2016.03.016
Abstract: Cancer is a kind of extremely complicated disease that associated with changes of lifestyle, genetic and epigenetic.
In general, we have made great progress in the fight against cancer, but it still need to be explored continuously. In addition to the
traditional cancer treatments, people now are paying more attention to the nutritional therapy. A lot of experimental evidence suggests
that yogurt and probiotics might have preventive effects on cancer. Probiotics are helpful to maintain health beneficial microbial
balance in the digestive tract of a human or other host. Probiotics may help strengthen immune functions and regulate homeostasis
and thus reduce side effects associated with chemotherapy and radiotherapy.
2016 Vol. 3 (3): 195-199 [Abstract] ( 307 ) HTML PDF (888 KB)  ( 242 )
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