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| The mechanism of anti-tumor for ketogenic diet |
| Beijing Institute of Translational Medicine/Chinese Academy of Sciences/Aviation General Hospital,Department of Surgery/Editorial Board of Electronic Journal of Metabolism and Nutrition of Cancer |
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Abstract Abstract: Ketogenic diet was a diet combination used primarily to treat epilepsy. With the high prevalence of chronic metabolic diseases and rapid social development, researchers began to focus on the relationship between KD and metabolic syndrome.Metabolic disorder is one of the main biological characteristics of cancer, and “Warburg effect” is the core of the reprogramming of cancer metabolism, resulting in increasing attention on KD with the ability of regulating glycometabolism. This reviwew demonstrated the antineoplastic mechanism of KD, including reducing glucose supply, decreasing the insulin and IGF-1, improving the immune response inhibition, regulating the mTOR pathway, increasing oxidative stress of tumor cells, controlling inflammatory reactions and regulating the function of mitochondria, which provided theoretical basis for application of KD to the cancer treatment in the future.
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