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Abstract To explore the application of individualized nutrition diagnosis and intervention based on cancer nutrition diagnosis and intervention system in patients with advanced cancer by chemotherapy. Methods All patients admitted to the hospital from January to June 2019 were screened by nutrition risk screening 2002(NRS 2002). One hundred and two patients with nutritional risk (NRS 2002≥3) were screened， which were randomly divided into the control group (n=51) and the observation group (n=51).The patients in the control group were managed by the nutrition support team， while the patients in the observation group were treated by the cancer nutrition diagnosis and intervention system. The changes of nutritional status between the two groups were compared before and after two cycles of chemotherapy， and the side effects of chemotherapy. Results After two cycles of chemotherapy， the body weight， muscle mass and appendicular skeletal muscle index of the two groups remained stable， and there was no significant difference compared with that before chemotherapy (P>0.05). In the control group， compared with those before chemotherapy， the levels of hemoglobin ［(99.17±12.54)g/L vs (115.26±13.14)g/L］， albumin ［(34.20±2.33)g/L vs (37.80±2.16)g/L］ and prealbumin ［(19.48±3.02)mg/dl vs (26.14 ±3.21)mg/dl］ were significantly increased (P<0.05).Similarly， in the observation group， compared with before chemotherapy， the levels of hemoglobin ［(110.08±15.74)g/L vs (122.91±23.08)g/L］， albumin ［(37.20±3.18)g/L vs (42.01±5.73)g/L］ and prealbumin ［(24.13±2.56）mg/dl vs （29.14±3.74）mg/dl］ were significantly increased (P<0.05).In addition， there were no significant differences in bone marrow suppression (5.9% vs 3.9%)， leukopenia (5.9% vs 7.8%) and digestive tract reaction (15.7 vs 19.6%) between the two groups (P>0.05).Conclusion Individualized nutrition diagnosis and intervention by cancer nutrition diagnosis and intervention system and nutrition support team can help patients with advanced cancer maintain their nutritional status during two cycles of chemotherapy and increase their tolerance to chemotherapy.
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