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| Advances in anti-tumor effect of mannose |
| 1，4 SONG Meng-meng，2CHEN Zhe-wen，3 LI Ye，1，4 SONG Chun-hua，5SHI Han-ping，6MIAO Ming-yong |
| 1Department of Epidemiology and Statistics， College of Public Health， Zhengzhou University， Zhengzhou 450001， Henan， China;2The Second Affiliated Hospital， Wenzhou Medical University， Wenzhou 325000， Zhejiang， China; 3Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 201203， China; 4Henan Key Laboratory of Tumor Epidemiology， Zhengzhou 450001， Henan， China; 5Department of Gastrointestinal Surgery/Clinical Nutrition， Beijing Shijitan Hospital/Capital Medical University Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition/Department of Oncology， Capital Medical University， Beijing 100038， China; 6Department of Biochemistry and Molecular Biology， The College of Basic Medical Sciences， The Second Military Medical University， Shanghai 200433， China |
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Abstract “Warburg effect” is one of the important metabolic characteristics of tumor cells. Tumor cells still undergo glycolysis under the condition of sufficient oxygen， which is also known as “aerobic glycolysis”. Many studies have shown that cancer is a metabolic disease. Therefore， to explore the changes and mechanisms of tumor metabolism， as well as tumor metabolic regulation therapy targeting tumor metabolism， have become a focus of tumor research in recent years. At present， some treatment methods based on tumor metabolism， such as ketogenic therapy and high-dose vitamin C， have gradually attracted the attention of basic research and clinical research. Recently， it has been reported that mannose can inhibit tumor growth， increase the anti-cancer effect of adriamycin and prolong the survival period of tumor-bearing mice. It mainly interferes with glucose metabolism and enhances the anti-tumor effect of chemotherapy drugs cisplatin and adriamycin to promote tumor cell apoptosis. In addition， mannose still has the effect of regulating immunity balance. Mannose， as a nutrient， is harmless to human health， and is expected to become an important nutrient for tumor metabolism regulation therapy， and can be combined with first-line tumor therapy (chemotherapy and radiotherapy) to improve the anti-tumor treatment effect， which has important clinical significance and application prospect.
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