当前肿瘤代谢调节治疗面临的问题及思考

doi:10.16689/j.cnki.cn11-9349/r.2019.03.004

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Abstract With advances in the research on cancer metabolic modulation therapy， it has been found that metabolic reprogramming of cancer cells with a single Warburg effect may not be representative of globally defined tumor metabolic reprogramming. At the same time， mitochondria play an important role in tumor metabolic reprogramming. Based on previous studies， we conclude that mitochondrial dysfunction can regulate tumor metabolic reprogramming through three modes: mitochondrial dysfunction-induced metabolic reprogramming， nuclear gene mutation-induced metabolic reprogramming， and mixed factors-induced metabolic reprogramming. Metabolic reprogramming of tumor cells is characterized by flexible metabolic plasticity due to differences in tumor genotype，tumor subtype， degree of differentiation， and changes of tumor microenvironment. Cancer cells can steal the metabolic wastes of tumor-related cells， and they are interdependent and interact with each other， showing the characteristics of metabolic symbiosis. In addition， cancer cells can also exhibit a stable heterozygous metabolic phenotype which affects the biological behavior of the tumor. This review begins with the current knowledge of tumor glucose regulation therapy， involves the current research problems， and summarizes the effects of mitochondrial dysfunction on metabolic reprogramming. It focuses on the metabolic plasticity of cancer cells， the metabolic coupling between tumor cells and tumor-associated cells， and the heterozygous metabolic phenotype of tumor cells. The effects of glycolysis and mitochondrial oxidative phosphorylation on the complexity of tumor metabolism are discussed， and the corresponding countermeasures are put forward for the complex tumor glucose metabolism.

Key words： Cancer metabolic modulation therapy Aerobic glycolysis Oxidative phosphorylation

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	SUN Xue-hua
	ZHOU Fu-xiang

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SUN Xue-hua,ZHOU Fu-xiang. Current problems and thinkings on the cancer metabolic modulation therapy[J]. Electron J Metab Nutr Cancer, 2019, 6(3): 287-294.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.03.004 OR http://182.92.200.144/EN/Y2019/V6/I3/287

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