肝癌代谢重编程研究及其临床应用进展

doi:10.16689/j.cnki.cn11-9349/r.2019.03.005

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Abstract Liver cancer is one of the most common malignant tumors in China， which is characterized by high degree of malignancy， insidious onset and lack of specific markers for early diagnosis and treatment. The development of liver cancer is its metabolic process. Similar to most other tumor cells， the metabolic process of liver cancer cells has undergone many significant changes compared to normal hepatocytes， such as abnormal activity of glycolysis， increased de novo synthesis of fatty acids and decreased oxidation， and accelerated glutamine catabolism. These abnormal changes in metabolism provide intermediate substances and energy for the rapid growth， proliferation and metastasis of liver cancer cells. At the same time， a variety of enzymes and signaling molecules involved in different metabolic processes also play an irreplaceable role in liver cancer. Therefore， the key metabolic enzymes and pathways that regulate the above metabolic processes are important targets for the diagnosis and treatment of liver cancer. In recent years， the reprogramming of liver cancer cells and its clinical application have made remarkable progress. In addition， the research for new markers has been the focus of liver cancer. This paper focuses on the abnormal changes of glucose， lipid， amino acid and nucleotide metabolism and its molecular mechanism and the potential clinical application value of metabolic marker molecules will be summarized and prospected.

Key words： Liver cancer Metabolism Diagnosis Therapy

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	Articles by authors
	1HOU Yi-ran
	1LI Bao-li
	2XING Jin-liang
	3LI Ji-bin

Cite this article:

1HOU Yi-ran,1LI Bao-li,2XING Jin-liang, et al. Metabolic reprogramming in liver cancer and its potential clinical implications[J]. Electron J Metab Nutr Cancer, 2019, 6(3): 295-300.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.03.005 OR http://182.92.200.144/EN/Y2019/V6/I3/295

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