口服营养补充对食管癌放疗患者营养状况的影响

doi:10.16689/j.cnki.cn11-9349/r.2019.03.017

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摘要目的探讨口服营养补充对食管癌放疗患者营养状况的影响。方法选取2016年9月至2018年4月期间中国人民解放军联勤保障部队第989医院肿瘤科收治能经口进食、拟行直线加速器适形调强放疗（60Gy/30F）且PG-SGA评分≥4分的食管癌患者100例作为研究对象，采用随机数字表法分为研究组（口服营养补充组）和对照组（常规液体组），比较两组患者放疗前后能量、蛋白质摄入量、体重以及白蛋白、血红蛋白及淋巴细胞计数等相关营养指标的变化情况。结果放疗前，两组患者年龄、体重、BMI、KPS评分、PG-SGA评分、营养相关指标均无统计学差异（P＞0.05）。放疗后，研究组和对照组体重均有所丢失，但研究组体重丢失无统计学差异（P＞0.05）；对照组放疗后血红蛋白、淋巴细胞、白蛋白和白细胞水平均有明显下降（P＜0.05）；研究组放疗后淋巴细胞有明显下降（P＜0.05），但白蛋白、血红蛋白和白细胞水平下降趋势不明显（P＞0.05）。结论对于能够经口进食又不能满足营养需求的食管癌放疗患者，口服营养补充有利于补充患者能量和蛋白质需要，保持放疗后体重，改善营养状况。

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	赵翔
	王文净

关键词 ：口服营养补充, 食管癌, 营养状况

Abstract：Objective To investigate the effect of oral nutrition supplementation on the nutritional status of esophageal cancer patients under radiotherapy.Methods A total of 100 patients with esophageal cancer admitted to the oncology department of The 989 Hospital of Joint Logistic Support Force of People’s Liberation Army from September 2016 to April 2018 who were able to eat through mouth and were prepared to undergo linear accelerator conformal intensity modulated radiotherapy (60Gy/30F) with PG-SGA score ≥4 were selected as research object. Random number table method was used to divide the study group (ONS group) and the control group (routine liquid group).The changes of energy， protein intake， body weight and albumin， hemoglobin， lymphocyte count and other related nutritional indicators before and after radiotherapy were compared between the two groups. Results Before radiotherapy， there were no statistically significant differences in age， weight， BMI， KPS score， PG-SGA score and nutrition-related indexes between the two groups (P>0.05). After radiotherapy， both groups lost weight， but the weight loss in the study group was no statistical significance (P>0.05). The levels of hemoglobin， lymphocyte， albumin and leukocyte in the control group all decreased significantly after radiotherapy (P<0.05). There was a significant decrease in lymphocytes in the study group after radiotherapy (P<0.05)， but no significant decrease in albumin， hemoglobin and leukocyte levels (P>0.05). Conclusion For patients with esophageal cancer who can eat through mouth but cannot meet nutritional requirements， ONS is beneficial to maintain energy and protein， maintaining body weight after radiotherapy， and improving nutritional status.

Key words： ONS Esophageal cancer Nutritional status

通讯作者: 王文净，电子邮箱：wangwj.0917@163.com

引用本文:

赵翔，王文净. 口服营养补充对食管癌放疗患者营养状况的影响[J]. 肿瘤代谢与营养电子杂志, 2019, 6(3): 357-360.
ZHAO Xiang，WANG Wen-jing. ONS improves nutritional status of esophageal cancer patients under radiotherapy treatment. Electron J Metab Nutr Cancer, 2019, 6(3): 357-360.

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