结直肠癌化疗患者营养状况及营养治疗研究进展

doi:10.16689/j.cnki.cn11-9349/r.2020.02.021

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摘要结直肠癌是常见的消化道肿瘤，其营养不良发生率高且严重。化疗是结直肠癌常见治疗方式之一，并与营养不良独立相关，化疗后患营养不良风险增大且营养不良进一步加重。同时，营养不良可导致患者化疗疗效差及预后不良，并增加化疗相关不良反应、影响患者生活质量及降低生存率等。营养治疗能够有效改善患者营养状况，在肿瘤综合治疗中有重要作用，且多学科团队合作是有效的营养干预模式。目前营养治疗主要包括营养咨询、口服营养补充剂、肠内营养和肠外营养等，相关指南和研究表明在营养治疗时应首选口服营养补充剂及肠内营养，仅在采用以上治疗后仍存在营养不足或无法进行肠内营养时行肠外营养。本文主要对结直肠癌患者营养状况与化疗之间关系、营养治疗的最新研究进展及相关指南进行综述，以期引起临床上对结直肠癌化疗患者营养治疗方面重视并提供参考。

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	贺艳玲
	蔡华
	张军玲
	杨瑜明
	彭娅

关键词 ：结直肠癌, 化疗, 营养状况, 营养治疗

Abstract：Colorectal cancer is a common gastrointestinal tumor with a high incidence of severe malnutrition. Chemotherapy is one of the common treatment methods for colorectal cancer and is independently related to malnutrition. After chemotherapy， the risk of malnutrition is further exacerbated. At the same time， malnutrition can lead to poor chemotherapy efficacy and poor prognosis of patients， and increase chemotherapy-related adverse reactions， affect patients’ the quality of life and reduce survival rate. Nutritional support therapy plays an important role in comprehensive tumor treatment， which can effectively improve the nutritional status of patients， and multiple disciplinary team is an effective nutritional intervention model. The current nutritional support therapy mainly includes nutrition consultation， oral nutritional supplements， enteral nutrition and parenteral nutrition. Relevant guidelines and research indicate that oral nutritional supplements and enteral nutrition should be preferred in nutritional support therapy， and parenteral nutrition is only performed when the nutritional deficiency after the above treatment or enteral nutrition is not available. This paper reviews the relationship between nutritional status and chemotherapy in colorectal cancer patients， and the latest research progress and related guidelines of nutritional support therapy， in order to attract clinical attention to nutritional support therapy in colorectal cancer patients undergoing chemotherapy and provide reference.

Key words： Colorectal cancer Chemotherapy Nutritional status Nutritional support therapy

基金资助:国家自然青年科学基金（81502114）
湖南省自然科学基金项目（2016JJ3082）
湖南省卫生计生委科研计划课题项目（B2015-84）

通讯作者: 彭娅，电子邮箱：pengyazjp@163.com

引用本文:

贺艳玲，蔡华，张军玲，杨瑜明，彭娅. 结直肠癌化疗患者营养状况及营养治疗研究进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(2): 245-249.
He Yanling， Cai Hua， Zhang Junling， Yang Yuming， Peng Ya. Research progress of the nutritional status and nutrition therapy for colorectal cancer patients undergoing chemotherapy. Electron J Metab Nutr Cancer, 2020, 7(2): 245-249.

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