益生菌联合麦芽糊精果糖肠内营养对胃癌患者术后的影响

doi:10.16689/j.cnki.cn11-9349/r.2020.01.009

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摘要目的研究添加益生菌联合麦芽糊精果糖肠内营养对胃癌患者术后恢复情况及主观舒适度、腹胀发生情况的影响。方法研究对象采用徐州医科大学附属连云港医院2016年6月至2019年6月收治的择期手术胃癌患者120例，采用随机数字表分为两组，分别为对照组和试验组，每组患者60例，两组患者均进行胃癌D2根治术，手术后两组患者均采取SOX方案进行化疗。试验组患者术后采取添加益生菌联合麦芽糊精果糖肠内营养辅助性治疗。对照组患者采取添加益生菌的肠内营养治疗。治疗时间均为2周。观察两组患者的肠道微生态、营养状况、主观舒适度以及不良反应之间的差异。结果治疗后，两组患者的粪便乳酸杆菌、双歧杆菌、肠球菌、真杆菌均有所升高，且试验组乳酸杆菌、双歧杆菌、肠球菌、真杆菌菌落数明显高于对照组，其差异具有统计学意义（P<0.05）。两组患者的HB、HCT、TBIL、DBIL、IBIL、TP、ALB、PAB均有明显升高（P<0.05），且试验组患者的HB、HCT、TP、ALB、PAB、ALT明显高于对照组（P<0.05），TBIL、DBIL、IBIL明显低于对照组（P<0.05），两组患者的主观舒适度评分均显著下降，且试验组患者的主观舒适度评分显著小于对照组，试验组患者的腹泻、腹胀以及呕吐等情况发生率显著低于对照组，差异存在统计学意义（P<0.05）。结论益生菌联合麦芽糊精果糖肠内营养对胃癌患者术后使用，患者的主观舒适度以及营养状况均显著改善，腹胀、腹泻以及呕吐发生率显著下降，患者临床症状改善显著，建议临床推广。

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	马东波

关键词 ：胃癌根治术, SOX方案, 益生菌, 营养状况, 腹胀

Abstract：Objective To study the effects of probiotic enteral nutrition support combined with maltodextrin fructose drink on the recovery, subjective comfort and abdominal distension of patients with gastric cancer after operation. Methods 120 patients with gastric cancer who underwent elective surgery in Lianyungang hospital of Xuzhou Medical University from June 2016 to June 2019 were divided into two groups by random number table： control group and observation group, 60 cases in each group. Both groups underwent D2 radical gastrectomy for gastric cancer. After operation, both groups received SOX regimen for chemotherapy. The patients in the observation group were treated with probiotic enteral nutrition support combined with maltodextrin fructose beverage after operation. The patients in the control group received enteral nutrition support with probiotics. The treatment lasted for 2 weeks. The differences of intestinal microecology, nutritional status, subjective comfort and adverse reactions between the two groups were observed. Results After treatment, the number of Lactobacillus faecalis, Bifidobacterium, Enterococcus and Eubacterium in the two groups both increased, and the number of Lactobacillus, Bifidobacterium, Enterococcus and Eubacterium in the observation group was significantly higher than those in the control group (P<0.05). The levels of HB, HCT, TBIL, DBIL, IBIL, TP, ALB and PAB in the two groups were significantly increased (P<0.05), and the levels of HB, HCT, TP, ALB, PAB and ALT in the observation group were significantly higher than those in the control group (P<0.05), while the levels of TBIL, DBIL and IBIL were significantly lower than those in the control group (P<0.05). The subjective comfort score of the observation group was significantly lower than that of the control group, and the incidence of diarrhea, abdominal distension and vomiting of the observation group was significantly lower than control group (P<0.05). Conclusions Probiotic enteral nutrition support combined with maltodextrin fructose beverage can significantly reduce the incidence of abdominal distension, diarrhea and vomiting in patients with gastric cancer after operation. It is suggested that clinical application of probiotic enteral nutrition support combined with maltodextrin fructose beverage should be promoted.

Key words： Radical gastrectomy SOX regimen Probiotics Nutritional status Abdominal distension

通讯作者: 马东波，电子邮箱：mdpdoc@163.com

引用本文:

马东波. 益生菌联合麦芽糊精果糖肠内营养对胃癌患者术后的影响[J]. 肿瘤代谢与营养电子杂志, 2020, 7(1): 47-51.
Ma Dongbo. Effect of probiotic enteral nutrition support combined with maltodextrin fructose on postoperative patients with gastric cancer. Electron J Metab Nutr Cancer, 2020, 7(1): 47-51.

1.朱丽娜, 战玉芳, 张久超, 等. 益生菌联合肠内营养对食管癌患者术后胃肠功能的影响. 中国微生态学杂志. 2018；30(8)：924-927.
2.李倩, 刘菁, 韩丁, 等. 高活菌数益生菌发酵乳联合肠内营养在颅脑损伤术后患者中的效果观察. 中国医药. 2018；13(2)：224-226.
3.石婷婷, 张学广, 焦盈盈,等. 益生菌联合早期肠内营养对重型颅脑损伤病人生化及营养等指标的影响. 齐鲁医学杂志. 2017；32(5)：561-563.
4.陈启仪, 冯啸波, 倪玲, 等. 围手术期肠道微生态治疗对顽固性功能性便秘患者术后并发症及胃肠功能的影响. 中华胃肠外科杂志. 2017；20(12)：1365-1369.
5.赵荣飞, 王鑫鑫, 蓝忻, 等. 胃肝样腺癌临床病理特征及预后分析. 中华胃肠外科杂志. 2017；20(9)：1035-1039.
6.Lu Jun,Zheng Zhi-Fang,Li Ping,Xie Jian-Wei,Wang Jia-Bin,Lin Jian-Xian,Chen Qi-Yue,Cao Long-Long,Lin Mi,Tu Ru-Hong,Zheng Chao-Hui,Huang Chang-Ming. A Novel Preoperative Skeletal Muscle Measure as a Predictor of Postoperative Complications, Long-Term Survival and Tumor Recurrence for Patients with Gastric Cancer After Radical Gastrectomy. Annals of surgical oncology.2018；25(2)：439-448.
7.Jing G, Shangxiang C, Yongming C, et al. Combination of CRP and NLR： a better predictor of postoperative survival in patients with gastric cancer. Cancer Management and Research, 2018；10：315-321.
8.杨娜. 益生菌治疗新生儿喂养不耐受疗效分析. 安徽医药. 2017；21(10)：1883-1885.
9.陈钰, 田葵, 陶正贵. 全结肠旷置-回直肠侧侧吻合术治疗老年顽固性慢传输型便秘的疗效观察. 国际外科学杂志. 2018；45(8)：539-542.
10.Tan B, Li Y, Di Y. Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer.J Clin Lab Anal. 2018；32(4)：e22363.
11.Gisbert Javier P,McNicholl Adrian G. Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies.Helicobacter.2017；22(4).269-281.
12.Wang ZJ, Chen XF, Zhang Z X. Effects of anti-Helicobacter pylori, concomitant therapy and probiotic supplementation on the throat and gut microbiota in humans.Microb Pathog. 2017；109：156-161.
13.Bajpai VK, Chandra V, Kim NH. Ghost probiotics with a combined regimen： a novel therapeutic approach against the Zika virus, an emerging world threat.Crit Rev Biotechnol. 2018；38(3)：438-454.
14.Gorshein E, Wei C, Ambrosy S. Lactobacillus rhamnosus GG probiotic enteric regimen does not appreciably alter the gut microbiome or provide protection against GVHD after allogeneic hematopoietic stem cell transplantation.Clin Transplant. 2017；31(5)：415-433.
15.Manaka D, Nishitai R, Konishi S, et al. P2-5-21Phase II study of Ccr-based dose-control of S-1 in 1st line SOX + bevacizumab regimen for advanced colorectal cancer. Annals Oncology. 2015；26(suppl 7)：vii130.1-vii130.
16.Xie H, Lu Q, Wang H,et al. Effects of probiotics combined with enteral nutrition on immune function and inflammatory response in postoperative patients with gastric cancer. J BUON. 2018；23(3)：678-683.
17.Ogawa M, Anan T, Suzuki T, et al. Initialreport of Phase II study on Bi-weekly SOX plus Cetuximab treatment for Wild-type K-RAS advanced and recurrent colorectal cancer. Anticancer research. 2016；36(5)：2505-2511.
18.林泽晨.胃癌围手术期肠内营养支持治疗的研究进展.浙江医学.2019；41(13)：1452-1455.
19.甘涛,李威,夏涛,等.肠内营养支持联合生长抑素对胃癌根治术患者营养状况及预后的影响.中国药业.2018；27(4)：38-40.
20.於红梅. 术后早期肠内营养对胃癌术后胃肠功能恢复和营养状况的影响分析. 临床医药文献电子杂志. 2018；5(85)：51-66.