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2015 Vol. 2, No. 4
Published: 2015-12-09
 
1 Recognition of malnutrition
2015 Vol. 2 (4): 1-5 [Abstract] ( 297 ) HTML PDF (1177 KB)  ( 665 )
6 Heterogeneity of cancer metabolism
2015 Vol. 2 (4): 6-10 [Abstract] ( 296 ) HTML PDF (902 KB)  ( 244 )
11 The impact of gut microbial ecosystem on cancer treatment
2015 Vol. 2 (4): 11-14 [Abstract] ( 172 ) HTML PDF (905 KB)  ( 206 )
15 Vitamin D and lung cancer
2015 Vol. 2 (4): 15-18 [Abstract] ( 213 ) HTML PDF (1004 KB)  ( 196 )
19 Cancer immunonutrition therapy
2015 Vol. 2 (4): 19-24 [Abstract] ( 270 ) HTML PDF (2847 KB)  ( 210 )
25 Branched fatty acid esters
2015 Vol. 2 (4): 25-28 [Abstract] ( 322 ) HTML PDF (1055 KB)  ( 220 )
29 Expert consensus of enteral nutrition for esophageal cancer patients with radiotherapy
2015 Vol. 2 (4): 29-32 [Abstract] ( 354 ) HTML PDF (896 KB)  ( 465 )
33 Guidelines of oral nutritional supplements
2015 Vol. 2 (4): 33-34 [Abstract] ( 309 ) HTML PDF (874 KB)  ( 207 )
35 A meta-analysis of clinical characteristics of breast cancer patients with type-2 diabetes mellitus in Mainland China
Abstract: Objective To investigate clinical features and prognosis of breast cancer patients with type-2 diabetes mellitus in mainland China. Methods A systematic search of Cochrane library, Pubmed, EMBASE, CNKI, Wanfang and VIP from 2000 to 2014 was conducted. Case control studies combined with clinical features and prognosis of breast cancer patients with type 2 diabetes mellitus in mainland China were collected. RevMan 5.2 was used to synthesize literature data. Fixed-effect or random effects model was adopted according to heterogeneity. Results 14 studies met the inclusion criteria, including 3711 cases of patients (study group 1106 cases, 2605 cases in the control group). Diabetes was positively associated with later clinical stage (III-IV) and T stage (T3- T 4), higher recurrence rate and mortality rate 1.77 (95%CI=1.37-2.3, P<0.0001), 1.57 (95%CI=1.19-2.08, P=0.001), 1.93 (95% CI=1.56-2.39, P<0.00001), 1.64 (95%CI=1.18-2.28, P=0.03). The mean difference (mean difference, MD) for average age was 3.47 (95%CI=2.64-4.29, P=0.001) between the two groups. There were no statistical differences between other clinical features. Conclusions Our findings strongly support a relationship between diabetes and older age, later clinical stage and T stage, higher recurrence and mortality rate, and worse prognosis in breast cancer patients.
2015 Vol. 2 (4): 35-42 [Abstract] ( 280 ) HTML PDF (1191 KB)  ( 228 )
43 K-A-P analysis of nutritional oncology of Chinese cancer patients
Abstract: Objective A nationwide survey was conducted to investigate the situation of knowledge-attitude-practice (KAP) towards nutrition among cancer patients, and to provide scientific evidences for the further implementation of nutrition education and nutritional intervention on cancer patients. Methods A multi-center, prospective, observational study was preformed from December 2012 to May 2013. 1682 cancer patients were collected by convenience sampling method and investigated by using questionnaire. Results In total, the average of nutrition knowledge was 72.7 with the standard deviation (SD) of 28.70, the pass rate of 74.49% and the excellent rate of 56.24%. The average of nutrition attitude was 84.3 with the standard deviation (SD) of 20.40, the pass rate of 90.31% and the excellent rate of 74.97%. And the average of nutrition practice was 72.7 with the standard deviation (SD) of 19.18, the pass rate of 81.75% and the excellent rate of 50.30%. The correlation coefficient between K scores and A scores was 0.5109 with the p value less than 0.0001, and the correlation coefficient between K scores and the P scores was 0.2643 with the p value less than 0.0001, which means there are correlations between the K scores and A scores, the K scores and the P scores. There is no difference for the K scores and the A scores in SEX group (P>0.05), but the P scores in male group are higher than the female group (P<0.05). There is no difference for the pass rate of the K-A-P scores in SEX group (P>0.05). There is no difference for the excellent rate of the K scores and the A scores (P>0.05), but the excellent rate of P scores in male group are higher than Female group (P<0.05). Compared in different Age group, there is difference between the K scores and P scores (P< 0.05), and the group with age between 45 and 60 has the highest score. There is no significant difference for the A scores (P>0.05). There is difference for the pass rate of the K scores and A scores (P<0.05), the group with age older than 60 has the highest rate. There is no difference for the pass rate of the P scores. And there is no difference for the excellent rate of the K-A-P scores in different age group (P>0.05). There is difference for the K-A-P scores in different patients group with different degree, also for the pass rate and the excellent rate (P<0.05). The higher degree group is superior than the lower degree group. There is no different for the K-P scores, the pass rate, and the excellent rate in patients with different sick period. But there is difference for the A scores, the pass rate and the excellent rate, the group with shorter time is higher than the longer group. There is no difference for the K scores, the pass rate and the excellent rate in patients with different tumor locations (P>0.05). There is difference for the A-P scores and the excellent rate, the patients with digestive system tumors has the highest scores and the excellent rate. There is no difference for the pass rate of the A scores and P scores. The nutritional knowledge of patients were majorly from TV (56.48%), the doctor (54.40%), and books (43.46%). It’s not popular for the nutritional knowledge from magazines (25.51%), nutritionist (10.17%) and other sources (3.57%). Conclusions The cancer patients in our country have a positive attitude for the tumor treatment, but there nutritional knowledge and practice need be improved, the nutritional training is necessary.
2015 Vol. 2 (4): 43-47 [Abstract] ( 356 ) HTML PDF (992 KB)  ( 244 )
48 Multi-center clinical researches of new oral enteral nutrition in patients
Abstract: Objective The aim of this study was to understand nutritional status in hospitalized patients with collagen-based medical foods and standard enteral nutrition by muti-center clinical researches, and provide scientific reference for medical foods. Methods 6 units joint in this research. we collected 74 patients, patients were divided into two groups ( group with standard enteral nutrition and group with collagen-based medical foods) according to random number table, add 1673.6kJ(400 kcal)/d in 21 days, detect medical indicators ,laboratory examination and gastrointestinal reaction before and after the research. Results NRS2002 has significantly decreased and ALB has significantly increased after using enteral nutrition (P<0.025). Nutritional status, medical indicators, laboratory examination and gastrointestinal reaction have no difference in intervention group and control group(P>0.025). Conclusions The new type of enteral nutrition preparations and standard enteral nutrition preparations can effectively improve the nutritional status of patients.
2015 Vol. 2 (4): 48-51 [Abstract] ( 313 ) HTML PDF (1053 KB)  ( 218 )
58 Advanced research on anti-tumor effect of astaxanthin
Abstract: Objective To summarize the antitumor effect of astaxanthin and its mechanism. Methods We collected and analysed the results from articles related to astaxanthin and tumor. Results astaxanthin have a strong antioxidant effect. and astaxanthin can prevent cancer, inhibit tumor cell proliferation, promote apoptosis, inhibiting metastasis, enhance immunity, regulating cell communication to achieve antitumor effect. Conclusions Astaxanthin has antitumor effect, but the specific mechanism is still unclear. The clinical application of astaxanthin warrants large-scale prospective clinical trials.
2015 Vol. 2 (4): 58-62 [Abstract] ( 421 ) HTML PDF (1072 KB)  ( 213 )
63 Anti-inflammatory effects of dietary fiber
Abstract: Objective To summarize the definition and physiological function of dietary fiber and to conclude the mechanism of anti-inflammatory effect. Methods We review the role of dietary fiber definition, physiological function and the mechanism of antiinflammatory effect in the domestic and foreign published literature in recent years. Results Dietary fiber is a kind of carbohydrate polymers, which is composed of a variety of monomer component and can't be digested or absorbed by small intestinal. It could be classified into soluble dietary fiber and insoluble dietary fiber, of which the former one can be decomposed into short chain fatty acids by gut flora metabolism. Many recent studies have shown that dietary fiber or short chain fatty acids exerts a preventive effect on inflammation by affecting differentiation of inflammatory cells, expression of inflammatory cytokines, intestinal flora and intestinal mucosal barrier function. Conclusions Dietary fiber has certain function of anti-inflammatory, but much research is needed to explore the mechanism of the anti-inflammatory effect of dietary fiber.
2015 Vol. 2 (4): 63-68 [Abstract] ( 314 ) HTML PDF (1093 KB)  ( 235 )
69 Taste alteration in cancer patients
Abstract: Objective Taste alterations (TAs) are common symptoms in cancer patients. The mechanisms of cancer-related TAs are complex. By literature search, we found that the related research in China was very limited. The impact of TAs to patients was often ignored during the cancer clinical care. The objective of this article is to investigate the symptoms, mechanisms, impact and treatment of cancer-related TAs. Methods Literature search for cancer-related TAs was performed in PubMed up to July 2015, resulting 88 articles. We picked up the key information from each article and integrate them together into every conclusion. Results Symptoms of cancer-related TAs including changes in taste acuity& taste quality, food aversion and xerostomia. Mechanisms of TAs could be damages in sensory receptor cells, abnormal neuronal activity, mucositis and zinc depletion. TAs has impact on patient’s weight loss and quality of life. Treatment methods include protection of healthy tissue, medication therapy, educations and self-care strategies. Conclusions TAs are very common symptoms in cancer patients. The symptoms can strongly impact patient’s nutritional status and quality of life. Personalized treatment strategies are necessary in the clinical cares of cancer patients.
2015 Vol. 2 (4): 69-75 [Abstract] ( 257 ) HTML PDF (1134 KB)  ( 453 )
76 Vitamin C on KRAS mutant colorectal cancer
Abstract: Objective To summarize research outcomes about vitamin C selectively kills KRAS, BRAF mutant colorectal cancer cells in cancer treatment, analysis and generalize the physiological mechanism. Methods Related articles were retrieved by searching the PubMed and CNKI database with the key words “vitamin C” and “colorectal cancer”. Results Combine the metabolic characteristics of tumor and the influence by ROS, vitamin C can be transport into cancer cells accompany with high glycolysis level resulting from KRAS, BRAF mutant cell. Due to unbalanced oxidation-reduction state in cells, cancer cells were killed by energy supply blocked. Conclusions High doses vitamin C via intravenous administration can restrain tumor growth in KRAS and BRAF mutant mice, these finding may provide a mechanistic rationale for further clinical trials.
2015 Vol. 2 (4): 76-79 [Abstract] ( 295 ) HTML PDF (1118 KB)  ( 209 )
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