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| Vitamin C on KRAS mutant colorectal cancer |
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Abstract Abstract: Objective To summarize research outcomes about vitamin C selectively kills KRAS, BRAF mutant colorectal
cancer cells in cancer treatment, analysis and generalize the physiological mechanism. Methods Related articles were retrieved by
searching the PubMed and CNKI database with the key words “vitamin C” and “colorectal cancer”. Results Combine the metabolic
characteristics of tumor and the influence by ROS, vitamin C can be transport into cancer cells accompany with high glycolysis level
resulting from KRAS, BRAF mutant cell. Due to unbalanced oxidation-reduction state in cells, cancer cells were killed by energy
supply blocked. Conclusions High doses vitamin C via intravenous administration can restrain tumor growth in KRAS and BRAF
mutant mice, these finding may provide a mechanistic rationale for further clinical trials.
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Chen Zhe-wen，Zhang Jie， Wang Zheng-ping，Song Meng-meng，Zhang Qi-yu， Miao Ming-yong，Shi Han-ping. The relationship between monocarboxylate transporter and tumor metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 266-271. |
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1WANG Qian, 1LIU Jie, 1WANG Ning, 1QI Hong-bing, 2MO Fu-quan, 1ZHOU Wen-su, 3ZHANG Pei-jun . The clinical significance of survivin mRNA expression in peripheral blood of patients with colorectal cancer[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 79-82. |
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2015, Vol. 2 
