单羧酸转运载体与肿瘤代谢的关系

doi:10.16689/j.cnki.cn11-9349/r.2019.02.021

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Abstract Monocarboxylate transporters (MCTs) are important transmembrane transporters responsible for monocarboxylate metabolites such as pyruvate， lactate， ketone bodies. They promote nutrient absorption of these substances and maintain the metabolic balance of cells. The expression of MCT in tumors is significantly up-regulated， which is closely related to glucose metabolism， lipid metabolism， energy metabolism and the formation of tumor microenvironment， and plays an essential role in maintaining the high glycolytic state of tumor cells. In some tumors， lactic acid is produced by glycolytic cells in the hypoxic region， excreted into the tumor microenvironment by MCT4， and then taken up by peripheral oxidized cells expressing MCT1， finally enters the TCA cycle and becomes a fuel for respiration. Pyruvate is also effluxed out of tumor cells by MCT1 and MCT2， while pyruvate in the tumor microenvironment promotes lung metastasis of breast cancer. At the same time， MCT promotes the formation of acidic tumor microenvironment， which is not only conducive to the growth， proliferation and metastasis of tumors， but also causes the death of normal cells around the tumor. The immunosuppression of tumors is also related to this. A number of studies have proved that the high expression of MCT1 and MCT4 is positively correlated with tumor malignancy and prognosis. Inhibition of MCT expression influences tumor growth， proliferation and metastasis， which provides potential therapeutic targets for targeted therapy. Currently MCT inhibitors such as CHC， AR-C155858 and AZD3965 are lack of selectivity for MCT subtypes， but have shown good therapeutic effects. While developing new MCT inhibitors， exploring strategies for joint application with traditional tumor therapies has a good clinical application prospect.

Key words： MCT Tumor metabolism Glycolysis Targeted therapy

Fund:国家自然科学基金(81672888)；国家自然科学基金(81570569)；山东省抗体制药协同创新中心（聊城大学）开发课题项目（CIC-AD1804）

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	Articles by authors
	Chen Zhe-wen
	Zhang Jie
	Wang Zheng-ping
	Song Meng-meng
	Zhang Qi-yu
	Miao Ming-yong
	Shi Han-ping

Cite this article:

Chen Zhe-wen,Zhang Jie,Wang Zheng-ping, et al. The relationship between monocarboxylate transporter and tumor metabolism[J]. Electron J Metab Nutr Cancer, 2019, 6(2): 266-271.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11-9349/r.2019.02.021 OR http://182.92.200.144/EN/Y2019/V6/I2/266

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