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肿瘤代谢与营养电子杂志
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膳食营养素与肝癌关系研究进展
肝癌的发病机制较复杂,主要包括遗传、环境和饮食因素,其中饮食因素对肝癌的发生、发展的影响一直是研究的热点。 不良的饮食习惯和不合理的膳食搭配都有可能通过改变代谢途径而导致肿瘤的发生。此外,手术、放化疗、局部消融被认为是肝癌最 有效的治疗途径,但营养不良、不良反应和耐药性等限制了其临床疗效。营养干预对肿瘤放化疗效果具有重要影响。合理的膳食营养 及部分天然食物活性成分可提高抗癌药物的疗效,具有增效减毒的效果。因此,膳食营养干预不仅能有效预防肝癌的发生,也可提高 治疗耐受性和治疗效果。研究膳食因素和营养因素与肝癌关系有利于了解食物营养在肝癌发生、发展中的作用,本文对近年来膳食脂 肪、蛋白质、碳水化合物三大营养素以及部分微量营养素对肝癌影响方面的研究进行综述,并从膳食营养素的角度综合分析肝癌的饮 食营养干预策略。
聊城大学生物制药研究院,山东 聊城 252000
Progress in understanding the relationship between dietary nutrients and liver cancer
The pathogenesis of liver cancer is complex, including genetic factors, environmental factors and dietary factors, in which the influence of dietary factors on the occurrence and development of liver cancer has been the focus of research. Poor eating habits and unreasonable dietary combinations may lead to cancer by changing the metabolic pathway. In addition, surgery, radiotherapy, chemotherapy, and local ablation are considered to be the most effective ways to treat liver cancer, but malnutrition, side effects, and drug resistance limit its clinical efficacy. More and more studies have shown that nutritional intervention has an important influence on the effect of cancer radiotherapy and chemotherapy. Reasonable dietary nutrition and some natural food active ingredients can improve the efficacy of anti?cancer drugs and have the effect of increasing efficacy and reducing toxicity. Therefore, dietary nutrition intervention can not only effectively prevent the occurrence of liver cancer, but also improve treatment tolerance and therapeutic effect. The study of the relationship between dietary and nutritional factors and liver cancer is helpful to understand the role of food and nutrition in the occurrence and development of liver cancer and provide theoretical basis for the prevention of liver cancer. This paper reviews the studies on the effects of dietary fat, protein, carbohydrates and some micronutrients on liver cancer in recent years, and comprehensively analyzes the dietary nutrition intervention strategies for liver cancer from the point of view of dietary nutrients.
Institute of Biopharmaceutical, Liaocheng University, Liaocheng 252000, Shandong, China