Abstract:Objective To explore the application of nutritional risk screening before TACE in patients with liver cancer and its influence on the curative effect, quality of life and prognosis. Methods From January 2013 to December 2018, 180 patients with advanced liver cancer treated by TACE were selected from Beijing Shijitan Hospital affiliated to Capital Medical University. According to nutrition risk screening 2002 (NRS 2002), the study population was divided into two groups:one group with nutrition risk (NRS 2002≥ 3 points) and another group without nutrition risk (NRS 2002<3 points). Further, the basic clinical characteristics, physical and biochemical indexes reflecting nutritional status, therapeutic effect, complications and quality of life scores were compared between the two groups. Kaplan Meier method was used to analyze the survival of the patients, and the incidence of other clinical end-point events such as gastrointestinal hemorrhage and hepatic encephalopathy were compared. Results Among the 180 patients who met the inclusion criteria, there were 85 patients without nutritional risk and 95 patients with nutritional risk. The incidence of nutritional risk was 52.8%. There were statistical differences in triceps skinfold thickness, upper arm muscle circumference, body mass index, and albumin between the two groups of patients (P<0.05). There was no statistically significant difference between total protein and preprotein in the two groups of patients (P>0.05). There was no significant difference in clinical effectiveness and postoperative complications of TACE in treating tumors between the two groups of patients (P>0.05). The quality of life score in patients without nutritional risk was higher than that of patients with nutritional risk (P<0.05). The 3-year survival rate of patients with nutritional risk was 54.74%; the 3-year survival rate of patients without nutritional risk was 68.24%, which was statistically significant (HR=0.61, P=0.05, 95%CI=0.38~0.98). The incidence of hepatic encephalopathy, hypoalbuminemia, and anemia was statistically different between the two groups (P<0.05). There was no statistical difference between the incidence of upper gastrointestinal bleeding and obstruction of portal vein thrombosis (P>0.05). Conclusions Nutritional risk screening is of great significance for patients undergoing TACE surgery. Nutritional risk is closely related to clinical outcomes, so it is particularly important to screen for patients with nutritional risks as early as possible and to provide interventions.
赵灵利,李婷婷,吴一凡,严炫晖,张裕. 肝癌患者行肝动脉化疗栓塞术前营养风险筛查的应用研究[J]. 肿瘤代谢与营养电子杂志, 2020, 7(1): 80-85.
Zhao Lingli, Li Tingting, Wu Yifan, Yan Xuanhui, Zhang Yu. Application of nutritional risk screening in liver cancer patients underwent transcatheter arterial chemoembolization. Electron J Metab Nutr Cancer, 2020, 7(1): 80-85.
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