胃癌围术期免疫营养治疗进展

doi:10.16689/j.cnki.cn11-9349/r.2020.04.021

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摘要免疫是保证人体健康的一种生理功能。目前，人类对其认识和发展共经历了4个阶段（经验免疫学、科学免疫学、现代免疫学、应用免疫学）。其中，在应用免疫学阶段中，衍生出很多分支，例如：免疫治疗、免疫预防及免疫营养等。随着免疫治疗在恶性肿瘤中的崭露头角，不仅证明了其在恶性肿瘤治疗中的可行性和重要性，而且使得人们将该思路拓展到解决肿瘤患者营养不良的问题上。这种通过调节免疫治疗营养不良的方法被称为“免疫营养治疗”，并在近几年临床实践中有了较快速的发展。其中，胃癌作为营养不良发生率最高的癌种，免疫营养治疗在胃癌中的发展备受关注。人们希望通过这种治疗方式降低围术期的不良临床结局、延长患者的总生存时间，此外还迫切希望其可改善患者的生活质量。本文对胃癌患者易发生营养不良的机制、免疫营养维持肠道屏障的作用、常见的免疫营养素在胃癌围术期患者的应用、机制、疗效等进行综述，为胃癌患者围术期的免疫营养治疗提供临床参考。

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关键词 ：胃癌, 营养不良, 免疫营养

Abstract：Immunity is a physiological function to ensure human health. At present, human beings have experienced four stages in their understanding and development (empirical immunology, scientific immunology, modern immunology, applied immunology). Among them, in the application of immunology stage, derived a lot of branches, such as: immunotherapy, immune prevention and immune nutrition. With the emergence of immunotherapy in malignant tumors, it not only proves its feasibility and importance in the treatment of malignant tumors, but also makes people extend this idea to solve the problem of malnutrition in tumor patients. This method of regulating immunotherapy for malnutrition is called “immunonutrition therapy” and has been developed rapidly in clinical practice in recent years. Among them, gastric cancer has the highest incidence of malnutrition, and the development of immunonutrition therapy in gastric cancer has attracted much attention. It is hoped that this treatment can reduce perioperative adverse clinical outcomes, prolong patients overall survival, and improve patients quality of life. In this paper, the mechanism of malnutrition in patients with gastric cancer, the role of immune nutrition in maintaining intestinal barrier, and the application, mechanism and efficacy of common immunonutrients in patients with gastric cancer during perioperative period were reviewed, so as to provide clinical reference for the treatment of immune nutrition in patients with gastric cancer during perioperative period.

Key words： Gastric cancer Malnutrition Immunonutritional therapy

基金资助:青海省卫生计生委指导性科研项目（2018-wjzdx-107）
青海省科技计划项目（2020-ZJ-779）

通讯作者: 张弢，电子邮箱：zhangtaoqh@163.com

引用本文:

王淼舟，柳仪，赵君慧柴海萍，路娜，张弢. 胃癌围术期免疫营养治疗进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(4): 484-489.
Wang Miaozhou, Liu Yi, Zhao Junhui, Chai Haipin, Lu Na, Zhang Tao. Progress of perioperative immunonutrition therapy for gastric cancer. Electron J Metab Nutr Cancer, 2020, 7(4): 484-489.

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