Research progress of flavonoids and their nanocrystals in tumor prevention and treatment
Gao Hui1, Fu Qiang2, Sun Jie1, Zuo Xuezh1, Yao Ying1
1.Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China；2.Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
Abstract：The poor accessibility to tumor tissues and a range of adverse drug reactions are still great concerns for cancer therapies. Flavonoids are documented great potential in combating various types of cancer, while their safety profile and tumor site-specific action have not been evaluated thoroughly. Low solubility, rapid metabolism and poor absorption of dietary flavonoids limit their antitumor activity in vivo. Moreover, flavonoids may interact with other therapeutic agents resulting their bioavailability reduction, especially through biotransformation. Nanocarriers can alter pharmacokinetics and pharmacodynamic profile of incorporating drug. Moreover, nanocarriers are designed for targeted drug delivery, improving the bioavailability of poorly water-soluble drugs, delivery of macromolecules to site of action, and reducing ADRs. It has been shown the potential of flavonoids nano-formulations, especially quercetin, naringenin, apigenin, catechins and fisetin in the prevention and treatment of several types of cancer, both in vitro and in vivo studies. However, few clinical trials have yet to be performed. This review focuses on the impact of flavonoids nano-formulations on the improvement of their bioavailability, therapeutic and safety profile and will open new insights in the field of drug discovery for cancer therapeutics.
基金资助:国家自然科学基金项目（81703215， 81974381）
通讯作者:
姚颖，电子邮箱：yaoyingkk@126.com
引用本文:
高慧，付强，孙洁，左学志，姚颖. 黄酮类化合物及其纳米制剂在肿瘤防治中的研究进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(3): 362-365.
Gao Hui, Fu Qiang, Sun Jie. Zuo Xuezh, Yao Ying. Research progress of flavonoids and their nanocrystals in tumor prevention and treatment. Electron J Metab Nutr Cancer, 2020, 7(3): 362-365.
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