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肿瘤代谢与营养电子杂志
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乳铁蛋白及其衍生物抗肿瘤作用与机制研究进展
乳铁蛋白在过去的70年中被广泛研究,其多种生物学作用被科学界普遍接受。它不仅参与铁的储存和转运,而 且具有抗微生物、抗氧化、抗肿瘤、调节免疫系统功能等作用,被认为是一种新型的抗菌、抗癌物质。乳铁蛋白及其衍生物的外 源性治疗可有效抑制肿瘤的生长并降低肿瘤发生的敏感性。乳铁蛋白主要通过细胞膜破坏、凋亡诱导、细胞周期阻滞和细胞 免疫反应等途径发挥抗肿瘤作用。然而,关于乳铁蛋白抗肿瘤作用的潜在机制,目前还未完全明确。本文综述了乳铁蛋白及 其衍生物抗肿瘤的作用及机制研究。在这些机制的基础上,提出了应用乳铁蛋白和/或其衍生物抗肿瘤作用的新策略,讨论了 乳铁蛋白及其衍生物在抗肿瘤研究领域的潜力。
Mechanism underlying antitumor effects of lactoferrin and its derivatives
Lactoferrin has been extensively studied over the past 70 years, and its many biological functions are widely accepted by the scientific community. It is not only involved in iron storage and transport, but also has anti?microbial, anti?oxidation, anti?tumor, regulation of immune system function, etc. It is widely regarded as a new antibacterial and anticancer substance. Studies have shown that the exogenous treatment of lactoferrin and its derivatives can effectively inhibit tumor growth and reduce the sensitivity of tumor occurrence. Lactoferrin plays an anti?tumor role mainly through cell membrane destruction, apoptosis induction, cell cycle arrest and cellular immune response. However, the underlying mechanisms of the antitumor effects of lactoferrin are not fully understood. This paper reviews the antitumor effects and mechanisms of lactoferrin and its derivatives. On the basis of these mechanisms, a new strategy for the anti?tumor effect of lactoferrin and/or its derivatives is proposed, and the potential of lactoferrin and its derivatives in the field of anti?tumor research is discussed.