A reticular meta‑analysis of the evaluation of the therapeutic effect of different treatment methods on colon cancer patients with
liver metastasis
Objective To evaluate the effects of four treatment options on the survival of patients with liver metastases from
colon cancer. Methods Through searching PubMed, EMBASE, Cochrane Library, China Scientific Journals Network Publishing
Library Weipu Chinese Science and Technology Journal Full-text Database, China Biomedical Literature Database, Wanfang
Data Journal Paper Resources, China Scientific Citation Database and China Traditional Chinese Medicine Database, Clinical
Trial Registration Institution Website and Google Academic Baidu Academic and other databases were searched for relevant
literatures to obtain systemic chemotherapy, preoperative chemotherapy+surgery+postoperative chemotherapy, a clinical study on
the treatment of liver metastases from colon cancer with four treatment options: surgery+postoperative chemotherapy, surgery+
postoperative chemotherapy+radiofrequency ablation. According to the inclusion criteria and exclusion criteria, the literature was
screened and data were extracted. The quality of the literature was evaluated using Jadad tools, and stata was used. Net?like
meta?analysis was performed with GeMTC software, and the publication bias was evaluated by funnel plot method, Begg′s Test
and Egger′s Test, and the evaluation of heterogeneity among the included correlations was tested by Q test and I2 index. Results
A total of 10 studies, 4 treatments, and 1026 subjects were included. The results of the net?like meta?analysis showed that the
number of patients who survived the first year, the third year, and the fifth year after the treatment of preoperative chemotherapy+
surgery+postoperative chemotherapy was the highest among the four treatment options. Conclusion In the evaluation of the
number of survivors, the clinical effects of preoperative chemotherapy+surgery+postoperative chemotherapy are better than the
other three treatment options.
Abstract：Objective To evaluate the effects of four treatment options on the survival of patients with liver metastases from
colon cancer. Methods Through searching PubMed, EMBASE, Cochrane Library, China Scientific Journals Network Publishing
Library Weipu Chinese Science and Technology Journal Full-text Database, China Biomedical Literature Database, Wanfang
Data Journal Paper Resources, China Scientific Citation Database and China Traditional Chinese Medicine Database, Clinical
Trial Registration Institution Website and Google Academic Baidu Academic and other databases were searched for relevant
literatures to obtain systemic chemotherapy, preoperative chemotherapy+surgery+postoperative chemotherapy, a clinical study on
the treatment of liver metastases from colon cancer with four treatment options: surgery+postoperative chemotherapy, surgery+
postoperative chemotherapy+radiofrequency ablation. According to the inclusion criteria and exclusion criteria, the literature was
screened and data were extracted. The quality of the literature was evaluated using Jadad tools, and stata was used. Net⁃like
meta⁃analysis was performed with GeMTC software, and the publication bias was evaluated by funnel plot method, Begg′s Test
and Egger′s Test, and the evaluation of heterogeneity among the included correlations was tested by Q test and I2 index. Results
A total of 10 studies, 4 treatments, and 1026 subjects were included. The results of the net⁃like meta⁃analysis showed that the
number of patients who survived the first year, the third year, and the fifth year after the treatment of preoperative chemotherapy+
surgery+postoperative chemotherapy was the highest among the four treatment options. Conclusion In the evaluation of the
number of survivors, the clinical effects of preoperative chemotherapy+surgery+postoperative chemotherapy are better than the
other three treatment options.
1郭云童，2熊永强，1崔潇龙，1黄河. 对结肠癌肝转移患者不同治疗方案效果评价的网状
meta 分析[J]. 肿瘤代谢与营养电子杂志, 2021, 8(1): 48-53.
1Guo Yuntong, 2Xiong Yongqing, 1Cui Xiaolong, 1Huang He. A reticular meta‑analysis of the evaluation of the therapeutic effect of different treatment methods on colon cancer patients with
liver metastasis. Electron J Metab Nutr Cancer, 2021, 8(1): 48-53.
