晚期肿瘤患者家庭肠内营养治疗进展

doi:10.16689/j.cnki.cn11-9349/r.2020.03.003

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (591 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要营养不良为肿瘤患者最常见的并发症及致死因素，在晚期肿瘤患者中更为多见。由于住院时间缩短，治疗方式及目标改变，越来越多的患者选择在家庭中接受营养治疗，合理、有效地家庭营养治疗对改善晚期肿瘤患者的预后及生活质量具有积极作用，其中家庭肠内营养由于简便、安全成为晚期肿瘤患者家庭营养治疗首选的应用方式。规范的家庭肠内营养能够有效降低患者营养不良的发生率，不仅有助于改善和维持患者营养状况，提高生活质量，而且能够满足其生理、心理需要，避免了长期住院，有利于节省医疗费用，有明显的社会效益。然而，家庭肠内营养实施目前仍面临着多方面的挑战，包括肠内喂养装置、肠内营养配方组分、实践创新、医疗保障等。目前亟待探索规范、安全、可靠的管理实施方式来实现家庭肠内营养治疗，为建立规范的晚期肿瘤患者的家庭肠内营养模式提供思路。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	白倩
	王建

Abstract：Malnutrition is the most common complication and death factor in cancer patients, especially in advanced cancer patients. Due to the shortened length of hospital stay, changes in treatment methods and objectives, home nutrition support is widely accepted by patients. Reasonable and effective home nutrition therapy has a positive effect on improving the prognosis and quality of life of patients with advanced cancer. Meanwhile, home enteral nutrition has become the preferred method of home nutrition therapy for patients with advanced cancer due to its simplicity and safety. Standardized home enteral nutrition can effectively reduce the incidence of malnutrition, not only help to improve and to maintain the nutritional status of patients, to improve the quality of life, but also can meet their physiological and psychological needs, avoid long-term hospitalization. There are obvious social benefits in saving medical costs. However, the application of home enteral nutrition is undergoing challenges including enteral feeding devices, enteral nutrition formula components, practice innovation, and medical care. At present, it is urgent to explore a standardized, safe and reliable management implementation to achieve home enteral nutrition support and provide ideas for the establishment of a standardized home enteral nutrition model for patients with advanced cancer.

基金资助:国家自然科学基金项目（81973040）

通讯作者: 王建，电子邮箱：wangjian_1996@aliyun.com

引用本文:

白倩，王建. 晚期肿瘤患者家庭肠内营养治疗进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(3): 263-266.
Bai Qian, Wang Jian. Progress in home enteral nutrition on advanced cancer patients. Electron J Metab Nutr Cancer, 2020, 7(3): 263-266.

1.汤海涛,卢俊,高娜,等. 恶性肿瘤营养治疗新进展［J］. 临床普外科电子杂志, 2020, 8(1):9-14.
2.方玉,辛晓伟,王艳莉,等. 肿瘤患者家庭肠内营养治疗的规范化管理［J］. 肿瘤代谢与营养电子杂志, 2017, 4(1):97-103.
3.HEBUTERNE X, BOZZETTI F, MORENO VILLARES J M, et al. Home enteral nutrition in adults: a European multicentre survey［J］. Clin Nutr, 2003, 22(3):261-266.
4.王新颖,牛程麟,黄迎春,等. 单中心家庭肠内营养治疗应用情况分析［J］. 肠外与肠内营养, 2011, 18(4):200-202.
5.孙志伟,贾军,杨颖,等. 肠内营养治疗减轻晚期食管癌患者化疗不良反应［J］. 北京大学学报(医学版), 2020,52(2):1-15.
6.GAVAZZI C, COLATRUGLIO S, VALORIANI F, et al. Impact of home enteral nutrition in malnourished patients with upper gastrointestinal cancer: a multicentre randomised clinical trial［J］. Eur J Cancer, 2016, 64:107-112.
7.LI X, ZHOU J, CHU C, et al. Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy［J］. Head Neck, 2019, 41(10):3525-3534.
8.WONG A, GOH G, BANKS M D, et al. A systematic review of the cost and economic outcomes of home enteral nutrition［J］. Clin Nutr, 2018, 37(2):429-442.
9.GRAMLICH L, HURT R T, JIN J, et al. Home enteral nutrition: Towards a standard of care［J］. Nutrients, 2018, 10(8):1020.
10.KAZ′MIERCZAK-SIEDLECKA K, FOLWARSKI M, JANKOWSKA B, et al. Assessment of nutritional status of patients with cancer who are qualified for home enteral nutrition-a retrospective analysis［J］. EUR J TRAN CLIN MED, 2020, 3(1):16-23.
11.BISCHOFF S C, AUSTIN P, BOEYKENS K, et al. ESPEN guideline on home enteral nutrition［J］. Clin Nutr, 2020, 39(1):5-22.
12.中国老年医学学会营养与食品安全分会,中国循证医学中心,编辑委员会中国循证医学杂志,等. 老年患者家庭营养管理中国专家共识(2017版)［J］. 中国循证医学杂志, 2017, 17(11):1251-1259.
13.RIPAMONTI C, GEMLO B T, BOZZETTI F, et al. Role of enteral nutrition in advanced cancer patients: indications and contraindications of the different techniques employed［J］. Tumori, 1996, 82(4):302-308.
14.MARTIN L, WATANABE S, FAINSINGER R, et al. Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction［J］. J Clin Oncol, 2010, 28(28):4376-4383.
15.吴国豪,谈善军. 肿瘤患者营养治疗指南［J］. 中华外科杂志, 2017, 55(11):801-829.
16.BJORKLUND G, DADAR M, AASETH J, et al. Cancer-associated cachexia, reactive oxygen species and nutrition therapy［J］. Curr Med Chem, 2019, 26(31):5728-5744.
17.SANTARPIA L, PAGANO M C, PASANISI F, et al. Home artificial nutrition: an update seven years after the regional regulation［J］. Clin Nutr, 2014, 33(5):872-878.
18.石磊,龚杰,柳园,等. 我国家庭肠内营养研究文献的计量学分析［J］. 中华临床营养杂志, 2019, 27(2):76-83.
19.MARTIN K, GARDNER G. Home enteral nutrition: updates, trends, and challenges［J］. Nutrition in Clinical Practice, 2017, 6(32):712-721.
20.陈亚文,蒋翎翎. 家庭肠内营养照护者相关知识认知现状及分析［J］. 解放军护理杂志, 2018, 35(10):37-40.
21.ESCURO A A, HUMMELL A C. Enteral formulas in nutrition support practice: is there a better choice for your patient［J］. Nutr Clin Pract, 2016, 31(6):709-722.
22.FIETKAU R, LEWITZKI V, KUHNT T, et al. A disease-specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: results of a randomized, controlled, multicenter trial［J］. Cancer, 2013, 119(18):3343-3353.
23.LI K, XU Y, HU Y, et al. Effect of enteral immunonutrition on immune, inflammatory markers and nutritional status in gastric cancer patients undergoing gastrectomy: a randomized double-blinded controlled trial［J］. J Invest Surg, 2019,19:1-10.
24.NAGANO T, FUJITA H, TANAKA T, et al. Randomized controlled trial comparing antioxidant-enriched enteral nutrition with immune-enhancing enteral nutrition after esophagectomy for cancer: a pilot study［J］. Surg Today, 2013, 43(11):1240-1249.
25.张风芝,李岩岩,段晓萌,等. 谷氨酰胺肠内营养在局部晚期胃癌治疗中的应用［J］. 西北药学杂志, 2019, 34(2):238-241.
26.MIYATA H, YANO M, YASUDA T, et al. Randomized study of the clinical effects of ω-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer［J］. Nutrition, 2017, 33:204-210.
27.LI X K, ZHOU H, XU Y, et al. Enteral immunonutrition versus enteral nutrition for patients undergoing oesophagectomy: a systematic review and meta-analysis［J］. Interact Cardiovasc Thorac Surg, 2020, 30(6):854-862.
28.JOHNSON T W, SEEGMILLER S, EPP L, et al. Addressing frequent issues of home enteral nutrition patients［J］. Nutr Clin Pract, 2019, 34(2):186-195.
29.JUKIC P N, GAGLIARDI C, FAGNANI D, et al. Home enteral nutrition therapy: difficulties, satisfactions and support needs of caregivers assisting older patients［J］. Clin Nutr, 2017, 36(4):1062-1067.
30.KLEK S, HERMANOWICZ A, DZIWISZEK G, et al. Home enteral nutrition reduces complications, length of stay, and health care costs: results from a multicenter study［J］. Am J Clin Nutr, 2014, 100(2):609-615.