前列腺癌患者雄激素剥夺治疗后的代谢营养问题

doi:10.16689/j.cnki.cn11-9349/r.2020.02.019

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摘要前列腺癌是男性最常见的恶性肿瘤之一，雄激素剥夺治疗是前列腺癌一线治疗方案。长时间雄激素剥夺治疗前列腺癌患者持续处于雄激素低下状态会出现一系列代谢和营养问题，比如肥胖、糖尿病、脂肪代谢异常、代谢综合征、心血管疾病风险增加等，严重影响患者生活质量、肿瘤序列治疗的进行和预后。但相关针对性研究较少，本文对长时间雄激素剥夺治疗前列腺癌患者的代谢和营养问题，就肥胖、糖尿病、血脂异常以及代谢综合征几个方面，进行深入讨论并对相关研究进行展望。

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	蔡建良
	董光
	石汉平

关键词 ：前列腺癌, 雄激素剥夺治疗, 代谢, 营养

Abstract：Prostate cancer is among one of the most common malignant tumors in men， and androgen deprivation therapy is the first-line treatment for prostate cancer. Prolonged androgen deprivation therapy for patients with prostate cancer who continues to be in a state of low androgen will have a series of metabolic and nutritional problems， including increased risk of obesity， diabetes， abnormal fat metabolism， metabolic syndrome， and cardiovascular disease， etc. The adverse health effect has a negative influence on patient’s quality of life， the implementation of cancer sequential treatments， and the prognosis. However， there are few relevant researches in this field. This article focuses on the metabolism and nutritional issues of prolonged androgen deprivation therapy for prostate cancer patients， discusses in-depth on the obesity， diabetes， dyslipidemia， and metabolic syndrome， and prospects for future research.

Key words： Prostate cancer Androgen deprivation therapy Metabolism Nutrition

基金资助:国家重点研发计划项目（2017YFC1309200）

通讯作者: 石汉平，电子邮箱：shihp@ccmu.edu.cn

引用本文:

蔡建良，董光，石汉平. 前列腺癌患者雄激素剥夺治疗后的代谢营养问题[J]. 肿瘤代谢与营养电子杂志, 2020, 7(2): 236-239.
Cai Jianliang1， Dong Guang2， Shi Hanping3. Review on metabolism and nutrition after androgen deprivation therapy in prostate cancer patients. Electron J Metab Nutr Cancer, 2020, 7(2): 236-239.

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