1 Cancer Nutritional Treatment Center， Neijiang Second People’s Hospital，Neijiang 641000，Sichuan，China; 2 Marryhealth Enterprises (ChongQing) Ltd.， Chongqing 400117，China; 3The Second Retired Cadre Sanatorium in Harbin， Heilongjiang Provincial Military District， Harbin 150001， Heilongjiang， China; 4Medical Department/Department of Clinical Nutrition/Department of Psychiatry， Neijiang Second People’s Hospital， Neijiang 641000， Sichuan， China; 5Cancer Center， Neijiang Second People’s Hospital， Neijiang 641000，Sichuan，China; 6Department of Gastrointestinal Surgery/Clinical Nutrition， Beijing Shijitan Hospital/Capital Medical University Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition/Department of Oncology， Capital Medical University， Beijing 100038， China
Abstract：Objective To explore the effect of ABD bioactives on myelosuppression alleviation in lung cancer patients during chemotherapy. Methods 44 lung cancer patients who received chemotherapy were randomly divided into intervention group and control group. 22 lung patients in intervention group received ABD Bioactives for adjuvant therapy. 22 lung cancer patients were treated conventionally. The difference of myelosuppression was compared between the two groups. Results 43 patients completed chemotherapy as planned， and 1 patients of the control group terminated chemotherapy due to severe myelosuppression. Myelosuppression of intervention group was significantly alleviated (P<0.05). The incidence of myelosuppression of Ⅲ~Ⅳ was significantly lower (P<0.05)， and the inhibition of leukocytes， granulocytes and platelets was significantly alleviated (P<0.05，P<0.05，P<0.05) compared with the control group. The myelosuppression induced by paclitaxel +platinum-based agents， pemetrexed+ platinum-based agents was significantly alleviated (P<0.05，P<0.05，P<0.05，P<0.05) compared with the control group. Conclusion ABD Bioactives can alleviate chemotherapy-induced myelosuppression in lung cancer patients， especially reduce the incidence of Myelosuppression of Ⅲ~Ⅳ， increase the levels of leukocytes， granulocytes and platelets， reduce the toxicity and side effects of platinum-based agents， paclitaxel， antimetabolite.
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