Abstract：Objective To evaluate the effects of different nutritional support methods on short-term efficacy and adverse reactions of patients with advanced esophageal cancer during radiotherapy. Methods According to nutritional intervention， patients were divided into the experimental group and the control group. The experimental group （n=67） was given nasojejunal nutrition tube feeding， while the control group （n=67） was given dietary guidance， oral nutrition or parenteral nutrition. Short-term efficacy， incidence of adverse reactions and treatment completion were compared between the two groups， and nutrition-related adverse events were analyzed. Results The two sets of data were comparable and balanced. The effective rate of radiotherapy in the experimental group was higher than that in the control group， but there was no statistical difference （P>0.05）. The incidence of gastrointestinal bleeding grade 3 or above radioactive esophagitis in the experimental group was significantly lower than that in the control group （P<0.05）， but there was no difference in the incidence of grade 3 or above bone marrow suppression and grade 2 or above radioactive pneumonia （P>0.05）. The treatment completion rate of the experimental group was higher than that of the control group （P<0.05）. Weight loss at the end of radiotherapy and 1month after radiotherapy were significantly lower in the experimental group than those in the control group （P<0.05）. All patients in the experimental group were removed from the jejunal nutrition tube within 1month after the end of radiotherapy. 5.97% of the patients developed esophageal reflux， aspiration and aspiration pneumonia， without affecting the original treatment plan. Conclusion When patients with advanced esophageal cancer and high risk factors were treated with chest radiotherapy， nutritional support by tube feeding help to maintain body weight， reduce adverse reactions， and reduce treatment interruption.
程国威，孙莉，陈平，何响玲，苏丹，奚亨智，臧定骐. 鼻空肠营养治疗对食管癌放疗患者疗效和不良反应的影响[J]. 肿瘤代谢与营养电子杂志, 2019, 6(3): 332-336.
CHENG Guo-wei， SUN Li， CHEN Ping， HE Xiang-ling， SU Dan， XI Heng-zhi， ZANG Ding-qi. Nasojejunal nutrition therapy improves the efficacy and decreased adverse reactions of radiotherapy for esophageal cancer patients. Electron J Metab Nutr Cancer, 2019, 6(3): 332-336.
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