Adv Search
 
  Office
  About
  Links
PUBMed
www.dxy.cn
More>>  
 
  Visited
    Current Issue
2022 Vol. 9, No. 5
Published: 2022-10-09
 
536 Interpretation of Roles of Nutrition in Muscle Health of Community-Dwelling Older Adults Evidence-based Expert Consensus from the Asian Working Group for Sarcopenia
1 Sun Jianqin 2 Yuan Wuke 3Huang Jiani
Sarcopenia is a common disease in the elderly population that is associated with increased adverse outcomes including falls functional decline frailty mortality severely affecting quality of life and increasing health care costs. There are crucial steps to delay the development of sarcopenia and maintain the muscle health of the elderly like early screening early diagnosis and early intervention. Nutrition plays a key role in the treatment of sarcopenia. However nutritional interventions have not received sufficient attention in practice. The need for sarcopenia prevention and therapy is becoming more urgent because of the COVID-19 pandemic and the aging of the population. To highlight the important role of nutrition in the prevention and treatment of sarcopenia the Asian Working Group for Sarcopenia AWGS established a Special Interest Group SIG to form 14 nutritional consensuses from 6 themes for the elderly ≥60 years of age based on evidence-based medicine methods to retrieve papers published in 2016-2021 related to muscle health in Asians 1. nutritional status malnutrition and screening 2. diets and dietary patterns 3. nutritional supplementation 4. lifestyle interventions 5. outcomes and assessment 6. impacts of COVID-19. The consensus emphasizes the impact and role of nutrition and the COVID-19 pandemic on muscle health and sarcopenia in older adults providing a practical framework for addressing muscle health in the community. The article interprets the core information of the consensus.
2022 Vol. 9 (5): 536-537 [Abstract] ( 317 ) HTML PDF (774 KB)  ( 511 )
538 Interpretation of ESPEN Practical Guideline Clinical Nutrition in Surgery
Zhang Zhige,Tan Shanjun,Wu Guohao
Malnutrition is an important risk factor of postoperative complications which are commonly seen in surgical patients especially those with gastrointestinal surgeries. Perioperative nutrition especially early feeding after surgery is recommended to enhance postoperative recovery improve patients′ prognosis and quality of life. In order to carry out perioperative nutritional therapy standardly and rationally European Society for Parenteral and Enteral Nutrition ESPEN has released ESPEN Practical Guideline Clinical Nutrition in Surgery on 1 st July 2021. The new guideline is shortened and transformed based on the formal one for easier use in clinical practice. Ranging from general principle to specific diseases the guideline provides 37 recommendations on nutrition treatment for surgical patients and is complemented with flow charts. Therefore this ESPEN guideline is a practical tool for all professionals including physicians dieticians nutritionists and nurses during clinical practice.
2022 Vol. 9 (5): 538-548 [Abstract] ( 463 ) HTML PDF (10355 KB)  ( 207 )
549 Progress and mechanism of exercise therapy in cancer patients
1Zhang Fengmin,1Yu Zhen,1 2Zhuang Chengle
Malignant cancers have a poor prognosis and high mortality rate and pose a serious risk to human health. Traditional oncology treatment is based on surgery radiotherapy and chemotherapy but patients still face the threat of cancer recurrence and are often accompanied by poor quality of life impaired physical function and significant anxiety and depression. Exercise therapy one of the most accessible and convenient prognostic improvement treatment for cancer patients is recommended by many oncology rehabilitation guidelines. On the one hand physical exercise can enhance cardiopulmonary function and protein synthesis improve physiological skills and increase physiological reserves on the other hand it can also help improve metabolic and immune balance and create an anti-cancer microenvironment. Exercise therapy is an important form of cancer rehabilitation and is suitable for patients regardless of whether they are in the peri - operative period during radiotherapy or with diseases such as cachexia or sarcopenia. Choosing a scientific and reasonable exercise program with appropriate frequency and intensity can significantly improve the nutritional status of patients help them better complete their anti-cancer therapy reduce complications improve their quality of life and even prolong their survival time. This article will review the progress of clinical application of exercise therapy in oncology patients.
2022 Vol. 9 (5): 549-554 [Abstract] ( 320 ) HTML PDF (1643 KB)  ( 487 )
555 Potential preventive effect of time-restricted eating on cancer
1Fang Ruoxin,2Yan Ling,1Liao Zhengkai
Intermittent fasting is a novel dietary intervention strategy that has been demonstrated to improve the efficacy of malignancy treatment and reduce complications. Time-restricted eating is a specific form of intermittent fasting. It usually restricts only the daily eating window and not calories. In addition to weight management and improving metabolism like other intermittent fasting methods time-restricted eating also synchronizes circadian rhythms and affects autophagy levels which has potential anti-aging effects. Some studies have shown its potential to prevent tumorigenesis and slow tumor progressions. Moreover due to the unsophisticated implementation and mild side effects time-restricted eating is safe and well followed. It may become an adjuvant therapy and even a healthy lifestyle suitable for the long-term execution of cancer patients. This paper expounds on the potential impact mechanism of time-restricted eating on the prevention and treatment of cancer from three aspects improving obesity and metabolic disorders synchronizing circadian rhythm and up-regulating autophagy and current research progress related to tumors. The purpose of this review is to provide a theoretical basis and direction for future research to explore the potential preventive effect of time - restricted eating as a nutritional intervention on the occurrence of cancer and the role of treatment or adjuvant therapy for cancer. It is conducive to improve the nutritional strategy for cancer patients and improving the quality of life and prognosis of patients.
2022 Vol. 9 (5): 555-560 [Abstract] ( 249 ) HTML PDF (1928 KB)  ( 285 )
561 Interpretation of Guidelines for Nutritional Treatment Pathways for Adult Patients in China peripherally inserted central venous catheter
Wang Kai,Jiang Hua
Peripherally inserted central venous catheter PICC is very important for parenteral nutrition and chemotherapy in patients with carcinoma. In July 2021 Chinese Society of Nutritional Oncology released the Guidelines for Nutritional Therapy Pathways for Adult Patients in China. To provide patients with safe and effective PICC this guideline is formulated in accordance with the principles of evidence-based medicine and based on the best current evidence. The guidelines are written concisely and easily for clinicians and nurses to use in clinical practice. The guidelines give the level of evidence based on the GRADE and 8 recommendations on how to choose the puncture site how to guide the puncture how to maintain patency and how to treat after blockage. According to the guideline it would promote early recovery of patients and reduce catheter-related infection complications. This article mainly introduces and interprets the main contents of this guideline from the aspects of guideline overview PICC technology indications complications recommendations and evidence evaluation to provide the latest evidence-based medical evidence for the application of PICC during nutritional therapy in Chinese adult patients.
2022 Vol. 9 (5): 561-565 [Abstract] ( 393 ) HTML PDF (857 KB)  ( 367 )
566 Clinical significance of nutritional intervention in four-level prevention strategy of Alzheimer's disease
1Xu Jun,1Jiang Jiwei,2Shi Hanping
With the rising aged tendency of population Alzheimer􀆳s disease AD the leading cause of dementia in the elderly is the greatest and sharp increasing challenge for global public health and social care in the 21st century. Recently 􀆵ATN research framework has emphasized the core role of amyloid β Aβ plaques and hyperphosphorylated Tau-protein in the AD continuum. However over the past two decades clinical trials of single-agent drug targeted Aβ and Tau have frequently failed to cure or prevent disease progression in AD. Ad is still based on symptomatic treatment and the representative drugs are cholinesterase inhibitors and memantine. AD is among the least well-served therapeutic areas for drug treatments. These evidence have suggested that AD as a complex and multifaceted disease its management should turn the attention from single-agent drug to diet and lifestyle regulation and risk factors control. However there are significant gaps in knowledge in the impact of modern dietary structure and lifestyle changes. The important value of brain health and nutrition intervention in AD still remain unclear. The multidisciplinary comprehensive management strategy of Neurology Geriatrics and Clinical Nutrition is yet to be established. This review summarized the current evidence on diet and nutrition in AD patients. We wish to propose the term of 􀆵four- level prevention strategy of AD and the effect of nutrition in each level of prevention to provide new direction for the comprehensive management of AD in China.
2022 Vol. 9 (5): 566-571 [Abstract] ( 259 ) HTML PDF (1842 KB)  ( 476 )
572 Guidelines for the use of formula food for special medical purposes in cancer patients
Key Laboratory of Cancer FSMP for State Market Regulation Formula Food for Special Medical Purposes Application Committee China
Cancer patients are prone to decreased intake and tumor-specific metabolic abnormalities due to factors such as the tumor itself and the treatment received and the need for nutrients varies from that of the non-cancer population. The nutritional needs of such special status population need to be met by food for special medical purposes FSMP but there is no guideline for FSMP for cancer patients. Due to the lack of understanding of the particularity of nutritional needs of cancer patients the mechanism of metabolic disorders and the efficacy of nutritional therapy it leads to the limitations and irregularities of the application of FSMP in clinical practice. In order to standardize the application of FSMP and guide the practice of clinical nutrition therapy experts from Key Laboratory of Cancer FSMP for State Market Regulation Formula Food for Special Medical Purposes Application Committee China Nutrition and Health Food Association and Chinese Society of Nutritional Oncology collected analyzed discussed and summarized important relevant clinical study evidence and authoritative guidelines published in recent years under the guidance of evidence-based medicine and developed this FSMP guideline for cancer patients for the reference of clinicians dietitians clinical pharmacists hospital managers and patients and caregivers.
2022 Vol. 9 (5): 572-580 [Abstract] ( 759 ) HTML PDF (947 KB)  ( 571 )
581 Expert consensus on clinical application of Multivitamin for injection 13
Chinese Society of Nutritional Oncology Key Laboratory of Cancer FSMP for State Market Regulation Beijing Association of Oncology
Multivitamin for injection 13 is a compound vitamin preparation containing both 9 water-soluble vitamins and 4 fat-soluble vitamins which is used clinically for the prevention of vitamin deficiency in adults receiving parenteral nutrition and children over 11 years of age. Compared to Multivitamin for injection 12 vitamin K has been added for regulating coagulation maintaining bone health and other aspects in parenteral nutrition. Multivitamin for injection 13 was first marketed in the United States in 2003. However it has been marketed in China in late 2020 so domestic clinicians might have little experience with the injection. In 2015 Chinese Society of Parenteral and Enteral Nutrition issued Expert Consensus on Clinical Application of Vitamin Preparations which provided recommendations on vitamin supplementation in various clinical scenarios as well as the use of common clinical preparations of vitamins. In recent years many new advances have been made in the clinical application of vitamins. Therefore in order to promote the standardized use of Multivitamin for injection 13 by Chinese physicians improve the understanding of the assessment of patients' vitamin metabolism and enhance the understanding of vitamin deficiency and further promote the development of research on multivitamins injections in China Chinese Society of Nutritional Oncology CSNO established the evaluation methods and contents of various indicators according to the current situation of nutritional diagnosis and treatment in China and evidence-based medical evidence published at home and abroad. Based on the 2015 Expert Consensus on Clinical Application of Vitamin Preparations and relevant international guidelines CSNO formed 15 recommendations through the expert consensus method involving the necessity comprehensiveness clinical application of Multivitamin for injection 13 and detection and monitoring of vitamins.
2022 Vol. 9 (5): 581-593 [Abstract] ( 573 ) HTML PDF (1035 KB)  ( 1092 )
594 Efficiency of Global Leadership Initiative on Malnutrition for nutritional assessment and prediction of postoperative complications in esophageal cancer
Zhou Lili, Wu Dan, Shi Haiyan
Objective This study aimed to evaluate the clinical value of Global Leadership Initiative on Malnutrition GLIM criteria for the the diagnosis of malnutrition and prediction of short-term clinical outcomes in esophageal cancer who underwent curative esophagectomy. Method This study included 158 esophageal cancer patients who were diagnosed and treated with curative esophagectomy in Rugao People's Hospital of from January 2019 to January 2022. Nutritional Risk Screening 2002 NRS 2002 and GLIM criteria were used for nutritional risk assessment and the diagnosis of malnutrition. All patients were divided into malnutrition and non - malnutrition group according to the GLIM criteria and the short-term surgical outcomes between the two groups were compared. In addition the univariate and multivariate Logistic regression analysis was conducted to determine the predictors of postoperative complications Clavien-Dindo grade≥grade Ⅱ for esophageal cancer patients. Result The preoperative nutritional risk was detected in 75 patients 47. 5% using NRS 2002 and the prevalence of malnutrition defined by GLIM criteria was 34. 2% 54 / 158 . Overall 11. 4% 18 / 158 of esophageal cancer patients had unintentional weight loss 10. 8% 17 / 158 had a low body mass index BMI and 16. 5% 26 / 158 were diagnosed with sarcopenia. Compared with the non-malnutrition group GLIM-defined malnutrition group had a higher proportion of preoperative neoadjuvant chemotherapy χ 2 = 4. 209 P= 0. 040 lower level of serum albumin 36. 7±5. 1 g / L vs 38. 6±3. 7 g / L t = 2. 691 P = 0. 008 lower BMI 21. 0± 3. 4 kg / m 2 vs 23. 1± 2. 5 kg / m 2 t = 4. 195 P< 0. 001 and skeletal muscle index at the third lumbar 40. 8±9. 4 cm 2 / m 2 vs 46. 7±7. 3 cm 2 / m 2 t = 4. 252 P<0. 001 . Moreover the length of hospital stays was longer t = -2. 152 P= 0. 033 the rates of postoperative complications χ 2 = 3. 842 P = 0. 044 and ClavienDindo≥ grade Ⅱ χ 2 = 5. 026 P = 0. 025 were higher especially for anastomotic leakage χ 2 = 4. 478 P = 0. 034 and pneumonia χ 2 = 9. 459 P = 0. 002 in malnutrition group than in non - malnutrition group. Univariate and multivariate logistic regression analysis demonstrated that preoperative hypoalbuminemia OR = 3. 784 95%CI = 1. 294-11. 070 P = 0. 015 and GLIMdefined malnutrition OR= 2. 834 95%CI = 1. 142-7. 029 P= 0. 025 were independent risk factors of postoperative complications for esophageal cancer patients who underwent curative esophagectomy. Conclusion GLIM is an useful tool to evaluate the preoperative nutritional status and predict the risk of postoperative complications and it could help surgeons to optimize the clinical management of esophageal cancer patients
2022 Vol. 9 (5): 594-601 [Abstract] ( 211 ) HTML PDF (1516 KB)  ( 260 )
602 Predictive value of L3-skeletal muscle index for survival outcome in esophageal cancer
Wu Jie， Zhou Jingjing,Chen Haisheng
Objective This study aimed to explore the optimal threshold and predictive value of skeletal muscle index at the third lumbar vertebra level L3-SMI for the prognosis of esophageal cancer patients. Method 150 esophageal cancer patients who were treated with surgical resection or curative chemoradiotherapy in Haian Hospital Affiliated to Nantong University from January 2016 to October 2020 were analyzed retrospectively. The L3-SMI was measured by analyzing abdominal computed tomography CT images. The optimal cutoff values of L3 - SMI for survival prediction of male and female patients were identified by the receiver operation characteristics ROC curves respectively. All patients were divided into high and low L3-SMI groups and Kaplan-Meier curve was used to estimate the 3-year overall survival OS rate of the two patient groups. In addition the independent prognostic factors of L3-SMI for esophageal cancer patients were further determined by the univariate and multivariate Cox regression analysis. Result In this study cohort the average value of L3-SMI for male and female patients were 43. 8±6. 3 cm 2 / m 2 and 38. 7±6. 7 cm 2 / m 2 respectively. The best cutoff values of L3-SMI for survival prediction of esophageal cancer patients were <42. 8 cm 2 / m 2 for males and <39. 2 cm 2 / m 2 for females respectively. The AUC value of the former was 0. 628 95% CI = 0. 515- 0. 742 and the latter had an AUC value of 0. 654 95%CI = 0. 513-0. 796 . All patients were divided into high L3-SMI n = 79 and low L3-SMI groups n = 71 based on the identified cutoff values. The results of survival analysis indicated that the 3-year OS rate of low L3-SMI and high L3-SMI group were 33. 5% and 54. 6% with a significant statistical difference χ 2 = 5. 358 P= 0. 021 . The subgroup analysis showed that low L3-SMI was significantly associated with worse OS in male patients 3-year OS rate 39. 8% vs 65. 4% χ 2 = 4. 752 P= 0. 029 . For female patients with esophageal cancer low L3-SMI group had a lower 3-year OS rate than high L3-SMI group 39. 8% vs 65. 4% but the survival difference was not statistically significant χ 2 = 1. 835 P= 0. 176 . The results of the univariate and multivariate Cox regres-sion analysis demonstrated that low L3-SMI HR= 1. 669 95%CI = 1. 062-2. 625 P= 0. 027 prognostic nutritional index PNI < 50. 2 HR=1. 700 95%CI = 1. 033-2. 796 P = 0. 037 and Ⅲ stage of the TNM stage HR = 1. 503 95%CI = 1. 077-2. 479 P = 0. 024 were independent prognostic factors for esophageal cancer patients. Conclusion L3-SMI is a valuable imaging parameter of prognostic assessment for esophageal cancer patients.
2022 Vol. 9 (5): 602-608 [Abstract] ( 243 ) HTML PDF (1883 KB)  ( 239 )
616 Effects of quercetin on the activity of lung cancer stem cells
1Zhu Jianyun,2Xie Chunfeng,2Zhong Caiyun
Objective To explore the inhibitory effects of quercetin on the activity of A549 lung cancer stem cells. The role of quercetin on Wnt / β-catenin and Sonic Hedgehog SHH pathway was further illustrated. Method The lung cancer cell line A549 was cultured in vitro and treated with various concentrations of quercetin 0 5 10 25 50 100 and 200 μmol / L for 24 48 and 72 h cell vitality was detected by MTT assay. Lung cancer stem cells were isolated and enriched using sphere-forming assay. The effects of quercetin on the sphere formation and the expression of lung cancer stem cell specific markers were evaluated. The role of quercetin on the proliferation and apoptosis of sphere-forming cells was further determined by flow cytometry and western blot analysis. Finally the protein levels of key molecules of Wnt / β-catenin and SHH pathways were detected by western blot assay. Result Our results showed that quercetin significantly inhibited A549 cell viability in a time- dependent and concertation-dependent manner. Compared to the vehicle control group quercetin markedly suppressed the sphere formation ability of A549 cells and reduced the expression of lung cancer stem cell specific markers CD133 CD44 and aldehyde dehydrogenas 1A1 ALDH1A1 . Furthermore quercetin reduced proliferation and induced apoptosis of lung cancer stem cells. The levels of proliferating cell nuclear antigen PCNA Cyclin D1 and B-cell lymphoma- 2 Bcl2 were markedly downregulated while the expression of Bcl2-associated X Bax and cleaved cysteinyl aspartate specific proteinase Cleaved Caspase 3 was significantly upregulated upon quercetin treatment. The Wnt / β-catenin and SHH-related proteins phospho-glucogen synthase kinase-3β p-GSK3β Ser9 β-catenin c-Myc glioma-associated oncogene homolog 1 GLi1 GLi2 and SHH in lung cancer stem cells were also inhibited by quercetin. Conclusion Quercetin significantly suppressed the activity of lung cancer stem cells which might be associated with the downregulation of Wnt / β-catenin and SHH pathways.
2022 Vol. 9 (5): 616-623 [Abstract] ( 241 ) HTML PDF (6396 KB)  ( 157 )
624 Applied research of Delphi method construction of Clinical Nutrition course content for clinical medical undergraduates
1Fan Yang,2Guo Shuyan,1Liu Jie,3Ni Geng,4Huang Jianjun,1Xu Hongxia
Objective Focusing on the National Nutrition Plan 2017 - 2030 to strengthen the nutritional capacity building requirements aimed at cultivating contemporary clinical medical undergraduate talents with post competency. This study designed and constructed the course content of Clinical Nutrition in line with the concept of new medical curriculum construction comprehensively improved the quality of Clinical Nutrition course and provided reference for clinical nutrition teaching. Through this study in order to better improve the comprehensive medical level solve public health problems and promote the reform of clinical nutrition education in clinical medicine. Method From December 2020 to March 2021 the study using the Delphi method 25 experts 22 actually participated from 11 provinces were selected. Through two rounds of questionnaire consultation the enthusiasm coefficient and authoritative coefficient of experts the full score rate the mean of importance score the coefficient of variation of each index and coordination coefficient Kendall's W were calculated. Result The curriculum content of Clinical Nutrition including 4 first-level indicators 12 second-level indicators and 27 third-level indicators were designed and constructed for clinical medical undergraduates. In the two rounds of questionnaire the enthusiasm coefficients of experts were 88% and 100% and the authoritative coefficients were >0. 7. The Kendall's W values were 0. 082 χ 2 = 82. 947 P = 0. 001 and 0. 277 χ 2 = 274. 585 P< 0. 001 respectively. Conclusion The Clinical Nutrition course content designed and constructed in this study can improve the clinical nutrition knowledge level and clinical nutrition diagnosis and treatment skills of medical students highlight the value of nutritional therapy have clinical practicability promote the development of clinical nutrition discipline and promote our country's clinical nutrition education to a new level.
2022 Vol. 9 (5): 624-630 [Abstract] ( 167 ) HTML PDF (898 KB)  ( 239 )
631 Effect of nutritional intervention compliance on nutritional status in malignant tumor patients with severe malnutrition
1Wang Hui,1Su Xianxu,1Hu Mengdi,1Zhou Xingye,2Wu Tiantian,2Song Chunhua
Objective To investigate the effect of nutritional intervention compliance on nutritional status and clinical outcome of patients with malignant tumor with severe malnutrition. Method A retrospective analysis was performed on 506 patients with malignant tumor and severe malnutrition admitted to the Department of Oncology from April 2019 to June 2021. The patients were screened and evaluated by nutritional risk screening NRS 2002 tumor nutrition assessment PG-SGA and simple dietary self-assessment tools. Using nutritional treatment principle of five steps to nutrition diagnosis treatment and curative effect evaluation and follow - up nutrition therapy plan according to the patient􀆳s compliance to group 2 weeks after treatment with nutrition to assess patients compliance score < 6 points into poor compliance group scoring six points into the good compliance group or higher Blood routine albumin prealbumin physical fitness height weight and other nutritional indicators were monitored in 2 groups. Result After nutritional intervention for tumor patients under 60 years old for two weeks the changes of blood potassium albumin grip strength and weight loss rate in two weeks were better in patients with good compliance than those with poor compliance all P < 0. 05 . The changes of RBC albumin prealbumin CRP grip strength and twoweek weight loss rate in tumor patients aged 60 years and over after nutritional intervention for two weeks were better in patients with good compliance than in patients with poor compliance all P < 0. 05 . The physical status score of tumor patients with good compliance 2 2 3 was lower than that of tumor patients with poor compliance 3 2 3 and the dietary score 3 1 3 was higher than that of tumor patients with poor compliance 2 1 3 . Patients with PS score < 3 points or ≥ 3 points and dietary score < 3 points or ≥ 3 points had better compliance than those with poor compliance in terms of albumin prealbumin grip strength and weight loss rate within two weeks after nutritional intervention all P < 0. 05 . Conclusion After standardized nutritional therapy patients with malignant tumors with severe malnutrition showed significant improvement in rapid changes such as albumin and prealbumin moderate changes such as grip strength and weight loss rate after 2 weeks in patients with good compliance.
2022 Vol. 9 (5): 631-638 [Abstract] ( 244 ) HTML PDF (918 KB)  ( 368 )
639 Resveratrol supplementation in the treatment of ulcerative colitis
Li Mingzhi, Liu Tiemei
Objective To investigate the clinical efficacy of resveratrol combined with mesalazine in the treatment of ulcerative colitis and the effect on inflammatory factors. Method A total of 112 UC patients admitted to Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from January 2018 to December 2020 were selected. Patients were divided into mesalamine treatment group and mesalazine combined with resveratrol treatment group 56 patients each. Patients in both groups were treated for 8 weeks. After treatment the efficacy of the two groups colonoscopy scores disease activity index quality of life anxiety and depression status and serum tumor necrosis factor-α TNF-α interleukin-10 IL-10 C-reactive protein CRP and erythrocyte sedimentation rate ESR before and after treatment were observed and compared. Result The overall effective rate of the combined treatment group was 96. 42% 54 / 56 higher than that of the control group 83. 92% 47 / 56 P = 0. 028 . The modified Mayo score Baron endoscopic score and DAI score in both groups were lower than those before treatment. The 3 scores in the combined treatment group were lower than that of the control group with statistically significant difference P<0. 05 . After treatment the scores of IBDQ quality of life anxiety and depression in both groups were better than those before treatment and the 3 scores in the combined treatment group were lower than those of the control group P<0. 05 . After treatment the serum levels of TNF-α IL-10 CRP and ESR in both groups were lower than those before treatment and the level of TNF-α IL-10 CRP and ESR of the combined treatment group were significantly lower than those of the control group P< 0. 05 . Conclusion Resveratrol supplemental has a significant effect on the clinical outcomes quality of life and systemic inflammation in patients with mild to moderate ulcerative colitis.
2022 Vol. 9 (5): 639-644 [Abstract] ( 241 ) HTML PDF (847 KB)  ( 101 )
645 Investigation and analysis of influencing factors of sarcopenia in hospitalized patients with malignant tumors
1 2Zhang Lingling,1 3Zheng Zheng,1He Li,1 3Li Na,1 3An Yonghui,2 3Li Zengning
Objective To investigate the occurrence of sarcopenia in hospitalized patients with malignant tumor analyze the related influencing factors and compare the differences in body composition serological indicators and quality of life between the sarcopenia group and the non-sarcopenia group so as to provide clinical data for improving the prognosis of patients. Method A total of 321 hospitalized patients with malignant tumor were collected and their body composition was measured by multi-frequency bioelectrical impedance analyzer. Sarcopenia was diagnosed according to the Asian Sarcopenia Working Group AWGS diagnostic criteria and divided into sarcopenia group and non-sarcopenia group. Nutritional status was assessed by patient subjective global assessment PGSGA systemic inflammatory response was assessed by improved Glasgow outcome score mGPS and quality of life was assessed by the European Quality of Life Collaboration Group cancer core scale QLQ-C30 . Univariate and multivariate Logistic regression were used to analyze the factors affecting the occurrence of sarcopenia. T test and rank sum test were used to compare the differences of body composition serological indexes and quality of life between the two groups. 0. 05 means the difference is statistically significant. Result In this study 102 patients were diagnosed with sarcopenia with an incidence of 31. 78% . The results showed that there were statistically significant differences in the incidence of sarcopenia among different PG-SGA body mass index BMI mGPS groups P< 0. 05 and BMI was an independent factor affecting the incidence of sarcopenia patients with body weight and hemoglobin albumin triglyceride were significantly lower than those without sarcopenia patients while extracellular moisture ratio was higher than those without sarcopenia. The scores of functional domains and symptom domains in quality of life were lower than those in patients without sarcopenia and the scores of constipation and anorexia were higher than those in patients without sarcopenia with statistically significant differences P<0. 05 . Conclusion The incidence of sarcopenia in hospitalized patients with malignant tumors is related to PG-SGA BMI and mGPS and BMI is an independent factor affecting the incidence of sarcopenia. Sarcopenia results in low body weight poor nutritional status high systemic inflammatory response score low phase angle level and poor quality of life.
2022 Vol. 9 (5): 645-651 [Abstract] ( 221 ) HTML PDF (876 KB)  ( 41 )
652 Application of enteral nutrition supporting rapid rehabilitation concept in perioperative period of gynecological malignant tumor
Wang Fang, Wei Ying,Wu Zhenzhen, Xu Wenjing, Zheng Jing, Wang Huiling
Objective To improve the nutritional status of patients reduce the incidence of postoperative complications and shorten the length of hospital stay through perioperative enteral nutrition support for gynecological malignant tumors in order to achieve rapid recovery. Method From October 2020 to October 2021 a total of 100 patients with gynecological malignant tumor in Gansu Provincial Maternity and Child Care Hospital were selected as the research object. They were randomly divided into two groups control group and experimental group 50 cases in each group. The experimental group was screened for nutritional risk by nutritional risk screening 2002 NRS 2002 and enteral nutritional support was provided if NRS 2002 ≥3. Perioperative nutritional status incidence of complications and length of hospital stay were compared between the two groups. Result Compared with the two groups the incidence of subjective severe malnutrition was 5. 59 times lower with enteral nutritional support OR= 5. 59 95%CI = 1. 12-27. 90 P= 0. 04 . Enteral nutritional support significantly reduced postoperative hypoproteinemia OR = 0. 43 95% CI = 0. 19 - 0. 97 P = 0. 04 and postoperative complications OR= 0. 22 95%CI = 0. 05-0. 96 P = 0. 04 . The average length of hospitalization in the experimental group was significantly shorter than that in the control group P = 0. 03 . Conclusion After NRS 2002 during perioperative period enteral nutritional support for patients with nutritional risk can significantly improve the perioperative nutritional status of patients reduce postoperative complications shorten the length of hospital stay and achieve rapid recovery.
2022 Vol. 9 (5): 652-657 [Abstract] ( 184 ) HTML PDF (839 KB)  ( 153 )
658 Effects of home enteral nutrition combined with probiotics on nutritional status of patients with esophageal cancer after radiotherapy
Zhuang Caili, Zhou Yin, Guo Qiaoling
Objective To explore the effect of home enteral nutrition combined with probiotics on nutritional status and cancer-related fatigue in patients with esophageal cancer after radiotherapy. Method 80 patients with esophageal cancer who received radiotherapy in the inpatient department of our hospital from January 2019 to September 2020 were selected as the research objects. According to the random number table method the 80 patients were divided into the experimental group and the control group with 40 cases in each group. The group received home enteral nutrition combined with probiotics while the control group received only routine enteral nutrition support. The nutritional index intestinal flora cancer-related fatigue and complications of the two groups were observed. Result After treatment the nutritional indexes of serum albumin hemoglobin prealbumin transferrin triceps skinfold thickness and upper arm muscle circumference in the experimental group were higher than those in the control group P<0. 05 the number of Bifidobacterium Lactobacillus Clostridium perfringens Enterobacter Enterococcus and Bacteroides in the experimental group were significantly higher than those in the control group P<0. 05 . The number of fatigue patients in the experimental group was significantly lower than that in the control group P<0. 05 . The incidence of pulmonary urinary system wound or catheter infection complications in the experimental group was lower than that in the control group P<0. 05 . Conclusion Home enteral nutrition combined with probiotics can improve the nutritional level of patients with esophageal cancer after radiotherapy which is beneficial to the recovery of intestinal flora and does not increase the discomfort of patients. Quality has far-reaching significance and it is worth exploring some influences in depth.
2022 Vol. 9 (5): 658-664 [Abstract] ( 166 ) HTML PDF (1283 KB)  ( 351 )
665 Clinical value of control nutritional status for the prognostic evaluation of cervical cancer patients with FIGO ⅠB~ ⅡA stage
Jiang Li,Qian Hua,Yuan Donglan, Zhao Yinling, Bu Xinhua
Objective To explore the clinical value of controlling nutritional status CONUT in the prognostic evaluation of cervical cancer patients. Method A total of 122 FIGO ⅠB~ⅡA stage patients who received surgical resection for cervical cancer in Taizhou People's Hospital from January 2016 to December 2018 were included in this study. All patients were divided into CONUT <3 points and CONUT ≥3 according to the CONUT score. The distributions of baseline characteristics between the two groups were compared by χ 2 test or Fisher's exact test. The survival curves were plotted and the 5-year overall survival OS rates of patients in CONUT <3 points and CONUT ≥3 points group were calculated using Kaplan-Meier curve. Univariate and multivariate Cox regression analysis was conducted to identify the independent prognostic factors for cervical cancer patients. Result The frequency of pelvic lymph node metastasis 42. 9% vs 23. 7% χ 2 = 4. 758 P= 0. 029 and the proportion of FIGO ⅡA stage 64. 3% vs 42. 5% χ 2 = 5. 229 P= 0. 022 were significantly higher in the CONUT≥3 points group than in the CONUT <3 points group. Kaplan-Meier curve showed that the 5- year OS rates of patients in the CONUT≥3 points and CONUT <3 points group were 63. 4% and 86. 6% respectively χ 2 = 11. 409 P= 0. 001 . Subgroup analysis further confirmed that CONUT≥3 points was a significant predictor of poor OS for cervical cancer patients irrespective of FIGO stage FIGO ⅠB stage 65. 8% vs 95. 5% χ 2 = 7. 902 P= 0. 005 FIGO ⅡA stage 62. 7% vs 76. 1% χ2 = 4. 206 P= 0. 043 . In addition the univariate and multivariate Cox analysis revealed that preoperative CONUT HR = 3. 542 95%CI = 1. 529 - 8. 207 P = 0. 008 tumor size HR = 2. 668 95% CI = 1. 158 - 6. 149 P = 0. 021 and pelvic lymph node metastasis HR= 3. 542 95%CI = 1. 529-8. 207 P = 0. 003 were independent prognostic factors for cervical cancer patients. Conclusion CONUT was an effective tool of prognostic evaluation and it might have an important clinical value for cervical cancer patients with FIGO ⅠB~ⅡA stage.
2022 Vol. 9 (5): 665-671 [Abstract] ( 200 ) HTML PDF (1722 KB)  ( 192 )
672 Progression in nutritional management of cancer patients during chemotherapy
Liu Yining,Cui Jiuwei
Malignancy has become the focus of studies around the world. Patients with cancer are prone to be malnourished and cancer-related malnutrition results from multiple factors. In addition to the malignancies itself the direct cause of death in 20% of cancer patients is nutritional deficiency and progressive cachexia. Malnutrition reduces the immunity and anti-infection ability of the body leads to the decrease of tolerance and sensitivity during chemotherapy and seriously affects the quality of life and prognosis. The incidence of nutritional risk in cancer patients is 40% - 70% . Early screening of nutritional risks in patients with cancer during chemotherapy and giving adequate and reasonable nutritional support to change their malnutrition is a major problem to be solved at present. Numbers of studies have shown that nutritional therapy during chemotherapy can significantly improve the malnutrition status of patients and have a positive impact on the prognosis. A comprehensive treatment mode based on five-step nutrition therapy has been gradually developed. Some new supplements and drugs for improving nutritional status have shown unique efficacy in clinical studies and animal trials. Large - scale prospective clinical trials are aimed at exploring effective means to improve nutritional status and prognosis. Nutritional therapy runs through antitumor therapy We discussed the nutritional status of cancer patients as well as the causes during chemotherapy and nutritional support therapy in perichemotherapy was reviewed.
2022 Vol. 9 (5): 672-680 [Abstract] ( 280 ) HTML PDF (1002 KB)  ( 291 )
681 A review of amino acid metabolism in triple negative breast cancer
Liu Xinran, Liu Peng
Triple-negative breast cancer is a subtype of breast cancer that lacks the expression of estrogen receptor progesterone receptor and human epidermal growth factor receptor 2. Its clinical characteristics are high degree of deterioration easy recurrence high metastasis rate and low survival rate. This kind of breast cancer accounts for 15% - 20% of all breast cancer cases and the treatment lacks effective targets. Metabolic abnormality is one of the important characteristics of tumor diseases. Therefore analyzing the characteristics of triple-negative breast cancer from metabolic pathway is a new direction of personalized nutritional therapy. Recent studies have found that the metabolism of nutrients especially amino acids in triple-negative breast cancer cells is different from normal cells and is also different from other subtypes of breast cancer cells. This paper reviews the characteristics of amino acid metabolism and related regulatory mechanisms in triple-negative breast cancer cells. It is found that the levels of glutamate / glutamine cystine / cysteine methionine glycine serine and tryptophan are different from normal cells or other types of tumor cells and the transformation and transport of amino acids are also in an abnormal regulatory state. Based on this characteristic regulating the corresponding metabolic pathway by limiting the target amino acids may have a good effect on the treatment of triple-negative breast cancer. At present nutrition deprivation has become an adjuvant treatment strategy for cancer cells. The in - depth study of the metabolic characteristics of the disease is of great significance for finding the target of nutrition therapy.
2022 Vol. 9 (5): 681-685 [Abstract] ( 254 ) HTML PDF (7776 KB)  ( 49 )
Copyright © Editorial Board of Electron J Metab Nutr Cancer
Supported by:Beijing Magtech