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| Clinical significance of nutritional intervention in four-level prevention strategy of Alzheimer's disease |
| 1Xu Jun ,1Jiang Jiwei ,2Shi Hanping |
| 1Department of Cognitive Impairment Neurology Center Beijing Tiantan Hospital Capital Medical University National Clinical Research Center for Neurological Diseases Beijing 100070 China
2Department of Gastrointestinal Surgery / Clinical Nutrition Beijing Shijitan Hospital Capital Medical University Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038 China |
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Abstract With the rising aged tendency of population Alzheimers disease AD the leading cause of dementia in the elderly is
the greatest and sharp increasing challenge for global public health and social care in the 21st century. Recently ATN research
framework has emphasized the core role of amyloid β Aβ plaques and hyperphosphorylated Tau-protein in the AD continuum. However over the past two decades clinical trials of single-agent drug targeted Aβ and Tau have frequently failed to cure or prevent disease progression in AD. Ad is still based on symptomatic treatment and the representative drugs are cholinesterase inhibitors and memantine. AD is among the least well-served therapeutic areas for drug treatments. These evidence have suggested that AD as a complex
and multifaceted disease its management should turn the attention from single-agent drug to diet and lifestyle regulation and risk factors control. However there are significant gaps in knowledge in the impact of modern dietary structure and lifestyle changes. The important value of brain health and nutrition intervention in AD still remain unclear. The multidisciplinary comprehensive management
strategy of Neurology Geriatrics and Clinical Nutrition is yet to be established. This review summarized the current evidence on diet
and nutrition in AD patients. We wish to propose the term of four- level prevention strategy of AD and the effect of nutrition in each
level of prevention to provide new direction for the comprehensive management of AD in China.
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