|
|
|
| Clinical value of control nutritional status for the prognostic evaluation of cervical cancer patients with FIGO ⅠB~ ⅡA stage |
| Jiang Li ,Qian Hua ,Yuan Donglan, Zhao Yinling, Bu Xinhua |
| Department of Obstetrics and Gynecology Taizhou People's Hospital Taizhou 225306 Jiangsu China |
|
|
|
|
Abstract Objective To explore the clinical value of controlling nutritional status CONUT in the prognostic evaluation of cervical
cancer patients. Method A total of 122 FIGO ⅠB~ⅡA stage patients who received surgical resection for cervical cancer in Taizhou
People's Hospital from January 2016 to December 2018 were included in this study. All patients were divided into CONUT <3 points
and CONUT ≥3 according to the CONUT score. The distributions of baseline characteristics between the two groups were compared by
χ
2
test or Fisher's exact test. The survival curves were plotted and the 5-year overall survival OS rates of patients in CONUT <3
points and CONUT ≥3 points group were calculated using Kaplan-Meier curve. Univariate and multivariate Cox regression analysis was
conducted to identify the independent prognostic factors for cervical cancer patients. Result The frequency of pelvic lymph node metastasis 42. 9% vs 23. 7%
χ
2 = 4. 758 P= 0. 029 and the proportion of FIGO ⅡA stage 64. 3% vs 42. 5%
χ
2 = 5. 229 P= 0. 022
were significantly higher in the CONUT≥3 points group than in the CONUT <3 points group. Kaplan-Meier curve showed that the 5-
year OS rates of patients in the CONUT≥3 points and CONUT <3 points group were 63. 4% and 86. 6% respectively
χ
2 = 11. 409
P= 0. 001 . Subgroup analysis further confirmed that CONUT≥3 points was a significant predictor of poor OS for cervical cancer patients irrespective of FIGO stage FIGO ⅠB stage 65. 8% vs 95. 5%
χ
2 = 7. 902 P= 0. 005 FIGO ⅡA stage 62. 7% vs 76. 1%
χ2 = 4. 206 P= 0. 043 . In addition the univariate and multivariate Cox analysis revealed that preoperative CONUT HR = 3. 542
95%CI = 1. 529 - 8. 207 P = 0. 008 tumor size HR = 2. 668 95% CI = 1. 158 - 6. 149 P = 0. 021 and pelvic lymph node
metastasis HR= 3. 542 95%CI = 1. 529-8. 207 P = 0. 003 were independent prognostic factors for cervical cancer patients. Conclusion CONUT was an effective tool of prognostic evaluation and it might have an important clinical value for cervical cancer patients
with FIGO ⅠB~ⅡA stage.
|
|
Received: 11 March 2022
|
|
|
|
|
|
|
