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2016 Vol. 3, No. 1
Published: 2016-07-02
 
1 Cancer fecal microbiota therapy
2016 Vol. 3 (1): 1-5 [Abstract] ( 223 ) HTML PDF (1054 KB)  ( 211 )
6 Warburg effect and immune escape of tumor cells
2016 Vol. 3 (1): 6-9 [Abstract] ( 227 ) HTML PDF (880 KB)  ( 365 )
10 Nutritional therapy of gastric paralysis
2016 Vol. 3 (1): 10-12 [Abstract] ( 194 ) HTML PDF (832 KB)  ( 223 )
13 Vitamin D reduces the graft versus host disease
2016 Vol. 3 (1): 13-17 [Abstract] ( 263 ) HTML PDF (1006 KB)  ( 215 )
18 Dietary Fibre
2016 Vol. 3 (1): 18-23 [Abstract] ( 234 ) HTML PDF (2774 KB)  ( 274 )
24 Oral or tube feeding?—Selection of enteral nutrition in gastrointestinal cancer patients
2016 Vol. 3 (1): 24-27 [Abstract] ( 243 ) HTML PDF (803 KB)  ( 229 )
28 General rules for nutritional therapy of cancer
2016 Vol. 3 (1): 28-33 [Abstract] ( 373 ) HTML PDF (1108 KB)  ( 208 )
34 Nutrition guidelines for lung cancer
2016 Vol. 3 (1): 34-36 [Abstract] ( 378 ) HTML PDF (747 KB)  ( 122 )
40 Association of mitochondrial DNA content with the risk of gastric cancer
Abstract: Objective Analyzing the mtDNA copy number in gastric cancer tissues and adjacent non-cancerous tissues, to investigate the relationship betweenmtDNA alteration and the clinicopathological parameters and patient prognosis in gastric cancer.Methods A total of 123 gastric cancer tissues and adjacent non-cancerous tissues were obtained from the tumor bank of Zhongnan Hospital of Wuhan Universitybetween 2011 and 2013. Relative mtDNA copy number was measured in triplicate by a quantitative real-time PCR assay. Using the statistic analysis analyzed the relationship between mtDNA content and clinicopathological features of the gastric cancer. Results The data showed that the majority of the cancer patients had low levels of mtDNA copy number as compared to adjacent non-cancerous tissues (P<0.0001). While there was no association of mtDNA content with the clinicopathological features, such as gender, age, tumor localization, differentiation, tumor invasion, lymph node metastasis,clinical stage, Her-2 expression, Ki-67 status. Additionally, by using the median ratio copy number as the cutoff point, the patients were separated into high and lowcopy number tumor groups, we found thatcompared with high mtDNA content, low mtDNA content was associated with T1+T2 group (P=0.04) and Ki-67negative (P=0.015). Conclusions In this study, the relative mean mtDNA content was lower in gastric cancer tissues than theadjacent non-cancerous tissues. Additionally, we found a strong link between increased mtDNA content and invasion of the tumor and Ki-67 status.We hypothesis that mtDNA copy number can be used as a new biomarker,and increasing the relative mtDNAcontent seems to be linked to the advancement of gastric cancer progression.
2016 Vol. 3 (1): 40-44 [Abstract] ( 331 ) HTML PDF (979 KB)  ( 203 )
45 The application of NRS 2002 and PG-SGA in chemotherapy patients with advanced gastric cancer
Abstract: Objective The aim of this study was to investigate the nutritional risk in patients with advanced gastric cancer received chemotherapy, using nutritional risk screening 2002 (NRS 2002) and patient-generated subjective global assessment (PGSGA), and to determine the potential relationship between the nutritional statusand the chemotherapy-related toxicity. Methods A continuous approach was used to screen patients with advanced gastric cancer, the NRS2002, PG-SGA, laboratory test indicators and other methods were applied to evaluate the nutritional risk and malnutrition of patients, the differences between the two kinds of tools in the investigation results were compared, and the correlation between nutritional risks and traditional objective indicators were analyzed. Results A total of 71 patients completed the nutrition survey. NRS survey shows that the incidence of nutritional risk was 67.61%, the incidence of malnutrition in PG-SGA was 80.28%, there was statistical significance between the two (P<0.05).When group according to the assessment results of NRS 2002, BMI was significantly different between the non-nutritional risk group and the nutritional risk group; when group by PG-SGA score results, prealbumin, albumin and CRP was significantly different between the two kinds of groups, the related incidence of adverse reactions (neutrophils reduced I/II and weary I/II) of patients with the nutritional risk group after their chemotherapy is higher than that of the patients belonging to the non-nutritional risk group. Conclusions Both NRS 2002 and PG-SGA are applicable to the nutritional status investigation of patients with advanced gastric cancer, but the malnutrition detection rate of PG-SGA was higher, so it can assess the nutritional status of patients more effectively. The PG-SGA scale is recommended to carry out the comprehensive evaluation for advanced gastric cancer patients before chemotherapy, so as to better guide clinical nutrition therapy.
2016 Vol. 3 (1): 45-48 [Abstract] ( 312 ) HTML PDF (884 KB)  ( 234 )
49 Analysis of nutritional risk and application of nutritional support in 80 patients with malignant tumor during chemoradiotherapy
Abstract: Objective To explore the prevalence of nutritional risk, undernutrition and application of nutritional support in cancer patients during chemoradiotherapy. Methods A total of 80 were enrolled from March 2010 to February 2011 .Nutritional risk screening(NRS 2002) was performed on first 48 hours incharge and the discharged day, Nutritional support was evaluated on the discharged day too. Results Overall prevalence of nutritional risk and undernutrition on first 48 hours incharge was 38.75% , 23.75% respectively, the prevalence of nutritional risk and undernutrition on the discharged day was 81.25%,40% respectively. Totally 20 patients with NRS≥3 were received nutritional support. Grade 3 or higher myelosuppression occurrence were 29%(9/31), 26.5%(13/49) among patients with NRS≥3 and NRS <3 respectively . Grade 4 anemia and thrombocytopenia only occurred in patients with NRS≥3. Conclusions A large proportion of cancer patients is at nutritional risk or undernutrition during chemoradiotherapy .The application of nutrition support is inappropriate. Assessing the nutrition risk dynamically, and carrying out effective nutrition support are the key points to prevent chemoradiotherapy patients from undernutrition.
2016 Vol. 3 (1): 49-51 [Abstract] ( 283 ) HTML PDF (829 KB)  ( 323 )
52 Diet on acid-base balance and its modulation
Abstract: Net acid production, which is produced as intermediary or end products of the endogenous metabolism, consists of volatile acids and fixed acid. It mainly comes from three sources: the metabolism of sulphur amino acids, the metabolism or ingestion of organic acids, and the metabolism of phosphate esters or dietary phosphoproteins. Net base production occurs mainly as a result of absorption of organic anions from the diet. Diet absorbed into the body will produce net acid or base, in order to maintain acid-base balance, the net acid or base will be neutralized by the buffer system or be excreted through lung and kidney. Because of the many reactions involved in the acid-base balance, we can’t measure the net endogenous acid production (NEAP) directly. Instead, the net acid excretion (NAE) assesses the acid-forming potential of the ingested diet based on its composition. So NAE can represent NEAP.However, NAE can’t be used to assess the acid-base balance of plasma.
2016 Vol. 3 (1): 52-57 [Abstract] ( 212 ) HTML PDF (1265 KB)  ( 281 )
58 L-carnitine intervention in energy metabolism of cancer cachexia patients
Abstract: Objective As cancer cachexia patients present low level of L-carnitine and abnormal energy metabolism, this study is to evaluate the impact of L-carnitine on energy metabolism of cancer cachexia patients. Methods We collected and analysed the results from the domestic and foreign published literature related to L-carnitine, cancer cachexia and energy metabolism in recent years. Results L-carnitine can ameliorate lipid metabolism disorders in cachexia patients, ameliorate anorexia by adjusting fatty acid metabolism in the hypothalamus; significantly decrease activities of proteasome related with protein metabolism, inhibit proteolysis,improve performance status and fatigue of patients; improve insulin resistance and increase insulin sensitivity. Conclusions The intervention of L-carnitine in cancer cachexia is worth paying attention to, but still need large sample research evidence to confirm,its underlying mechanisms also need further research.
2016 Vol. 3 (1): 58-62 [Abstract] ( 210 ) HTML PDF (948 KB)  ( 420 )
63 Dietary fiber and prostate cancer risk
Abstract: Objective To elaborate the possible relationship and mechanism between the intake of dietary fiber and prostate cancer risk, and provide evidence for the nutritional prevention of prostate cancer. Methods We review and research the domestic and foreign published literature about the relationship between dietary fiber and prostate cancer. Results The latest Meta analysis of case control study showed that dietary fiber can reduce the risk of prostate cancer, but the Meta analysis of cohort study showed that the intake of dietary fiber was not associated with the risk of prostate cancer. Effect of dietary fiber on prostate cancer may be involved in the change of SHBG, testosterone and estradiol levels, the improvement of insulin sensitivity, the decline of the activity of insulin like growth factor , the apoptosis in human prostate cancer cells and the inhibition of adhesion and migration of prostate cancer cells. Conclusions The mechanism of the effect of dietary fiber on prostate cancer needs to be further studied. The existing research can not completely support the theory that dietary fiber can reduce the risk of prostate cancer.
2016 Vol. 3 (1): 63-65 [Abstract] ( 212 ) HTML PDF (863 KB)  ( 194 )
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