|
|
|
| Metabolism of tumor growth & metastasis |
| NING Tao, BA Yi |
| Tianjin's Clinical Research Center for Cancer/Key Laboratory of Cancer Prevention and Therapy/National Clinical Research Center for Cancer/Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China |
|
|
|
|
Abstract As we know, tumor is a metabolic disease. During tumor development, cancer cells need to increase the biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis. The focus has been mostly on the metastatic style of the primary tumor, while metabolic adjustments during primary tumor growth and metastatic process have been less well known. Present evidences indicate that metabolic regularity of tumor development is dynamic. Moreover, emerging data suggest that, once
the tumor cells leave their primary sites, may show different metabolic styles, distinct from the primary tumor, to successfully survive and metastasis. In this review, we will summarize how the metabolic flexibility will be occurred during the primary tumor growth and metastatic process, and we will also explore how metabolic adaptation is influenced by the metastatic microenvironments. We hope
that this review will give information for the tumor metabolic research in the future.
|
|
|
|
|
|
| [1] |
WANG Chao-yun， DU Cheng， GUAN Xin， DU Xiao-wei， XU Zhu-xuan， ZHENG Zhen-dong. Advances in drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 382-385. |
| [2] |
SUN Xue-hua， ZHOU Fu-xiang. Current problems and thinkings on the cancer metabolic modulation therapy[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 287-294. |
| [3] |
1，4 SONG Meng-meng，2CHEN Zhe-wen，3 LI Ye，1，4 SONG Chun-hua，5SHI Han-ping，6MIAO Ming-yong. Advances in anti-tumor effect of mannose[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 283-286. |
| [4] |
1YAO Ke-qing， 1WANG Su， 1CHEN Shuang， 1SUN Yan-teng， 1LIU Qing-yang， 1CHEN Tao，1LIU Xue-hui， 2CONG Ming-hua. Application of individualized nutrition diagnosis and intervention in patients with advanced cancer[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 305-309. |
| [5] |
1，2ZHU Ming-xing， 1WU Chang-peng， 3YIN Liang-yu，1LU Zong-liang， 1LI Na，1LIU Jie， 1GUO Jing， 1XU Hong-xia. L-carnitine improves skeletal muscle cell atrophy of cancer cachexia by regulating lipid metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 320-325. |
| [6] |
ZHANG Xiao-wei， SHI Han-ping. Non-maligment bowel obstruction in the context of advanced cancer[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 361-364. |
|
|
|
|
