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| Clinical application of ketogenic diet in the treatment of cancer |
| 1 ZHANG Xu, 1 SUN Di, 2 JIANG Gui-chun |
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Abstract With the advancement of modern science and technology and the increasing knowledge of biochemistry, the role of nutrition in daily life and medical treatment is gradually emerging. The use of nutritionally relevant knowledge to supplement or even treat diseases with diet-controlled alternative drugs under pathological conditions has been achieved. In addition, the use of nutrition as an adjuvant therapy in a synergistic manner to enhance the drug effect and to reduce the possible side effects and dependence has also been widely confirmed in many fields. With the tumor cell metabolism in-depth study, a research shows that the most important feature shared by tumor cells is that they are mainly energized with glucose (Warburg effect) both aerobically and anaerobically. It is because of this special metabolic approach that dietary control is considered as an important strategy in cancer therapy. The ketogenic
diet is a high-fat, low-protein, and very low-carbohydrate diet that can potentially affect the treatment and prognosis of the tumor.As an important part of non-drug therapy, ketogenic diet therapy has been systematically applied in pediatric refractory epilepsy treatment both at home and abroad, and has achieved remarkable results. However, the application of ketogenic diet has rarely been reported in cancer treatment. Therefore, this article reviews the mechanism of action of ketogenic diet in cancer therapy and the effect of clinical application on cancer patients, and provides references for the study of non-drug treatment of cancer.
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