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| Glyoxalase I in tumor development and progression |
| XU Ning-jing, MIAO Ming-yong |
| Department of Biochemistry Molecular Biology, The Second Military Medical University, Shanghai 200433, China |
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Abstract Tumor metabolic changes is closely related to the occurrence and progression of human malignancies. Meanwhile
abnormal metabolism of tumor lead to the accumulation of cytotoxic metabolites such as methylglyoxal(intermediate products of
glycolysis), which are bad for cell survival. The research of recent years find that GLO I may inhibit the apoptosis of cancer cell
through the degradation of the toxic metabolite methylglyoxal which is produced in the process of carbohydrate metabolism. In
reverse, the inhibition of the expression of GLO I will accumulate methylglyoxal in cell which leads to the apoptosis of cancer cell,
thus achieve anticancer effect. This article makes some preliminary discussion on the structure and function of GLO I, its role in the
occurrence and development of tumor and relevant clinical appliance.
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