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Abstract Objective To summarize the function and research status of visceral fat (VF) removal. Methods The related
literatures were reviewed. Results Increased VF can result in insulin resistance (IR), excessive adipocytokines and in?ammatory
cytokines secretion, and glucolipid metabolism disorders, and is the key factor of type 2 diabetes, dyslipidemia, cardiovascular
diseases, metabolic syndrome and other metabolic complications. Obesity and visceral fat, both can increase the incidence of
malignant tumor, shorten the disease-free and overall survival, increase the risk of recurrence and death. The relationship between
visceral fat and malignant tumor is also related with insulin resistance, excessive adipocytokines and inflammatory cytokines
secretion, and systemic chronic inflammatory response status, which all induced by the VF. So the VF became the target of the
treatments and preventions of these diseases and surgical removal of part of VF directly is one way of them. In most of animal
experiments, surgical removal of part of VF directly has been shown to improve IR, increase insulin sensitivity, glucolipid
metabolism, reduce adipocytokines and inflammatory cytokines secretion and prevent tumorigenesis. But in human, due to the
limitation of anatomical and medical ethics, only great omentum can be removed in similar experiments, and most of the studies
have not found similar positive roles. Conclusions Many animal experiments have confrmed that visceral fat resection can improve
glucolipid metabolism and prevent tumorigenesis, but in clinical trials, the omentectomy, found no similar changes, which may be
associated with insuffcient excised fat mass, the specifc reason need further study.
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2015, Vol. 2 
