Effects of vitamin B2
combined with Kangfuxin Solution on oral mucositis and nutritional status of patients with head and
neck cancer after radiotherapy
Yin Qiujie ,Tang Yuanyuan, Wang Ji, Hua Yuchen
Department of Radiotherapy The First Affiliated Hospital of Nanjing Medical University / Jiangsu Provincial People??s Hospital Nanjing 210029 Jiangsu China
Abstract：Objective To analyze the effects of vitamin B2
combined with Kangfuxin Solution on oral mucositis and nutritional status
of patients with head and neck cancer after radiotherapy. Method A total of 108 patients with head and neck cancer diagnosis into our
hospital from January 2020 to January 2022 were prospectively enrolled. They were all treated with intensity-modulated radiotherapy
the total treatment dose was 60 ~ 74 Gy once a day five times a week for 6 ~ 7 weeks It can be combined with chemotherapy at the
same time. All patients had oral mucositis then they were randomly divided into control group and observation group with 54 cases in
each group. The control group only took vitamin B2
orally and the observation group combined with vitamin B2
and Kangfuxin solution.
The severity of oral mucositis grade Ⅲ/ Ⅳ was assessed according to the Radiation Therapy Oncology Group RTOG standard the
degree of pain was assessed by visual analogue scale VAS . Nutritional indicators included weight loss body mass index BMI loss
albumin loss prealbumin loss hemoglobin loss and total lymphocyte count loss as well as Patient Generated – Subjective Global
Assessment PG-SGA score adverse reactions included dry mouth nausea and vomiting thrombocytopenia neutropenia neurotoxicity
and nephrotoxicity. Result The incidence of grade Ⅲ/ Ⅳ oral mucositis in the observation group was significantly lower than that in
control group the disappearance time of oral mucositis was shorter than control group too P < 0. 05 . The pain VAS scores of the two
groups at 2h 4hand 6h after treatment were lower than before treatment and they in the observation group was furtherly less than
control group P < 0. 05 . The weight loss and BMI loss at 4 and 7 weeks after treatment albumin loss at 7 weeks after treatment in the
observation group were significantly lower than those in control group P < 0. 05 . The PG-SGA score of the observation group 7 weeks after
treatment showed that the nutritional status was better than control group P < 0. 05 . There was no difference of the incidence of adverse
reactions between the two groups P > 0. 05 . Conclusion Vitamin B2
combined with Kangfuxin Solution can greatly improve the oral
mucositis and nutritional status of patients with head and neck cancer after radiotherapy reduce pain which has a good clinical value.
收稿日期: 2022-03-15
通讯作者:
唐媛媛,电子邮箱:1552599118@qq.com
引用本文:
尹秋杰,唐媛媛,王霁,华羽晨. 维生素 B2 和康复新液改善头颈部肿瘤放疗患者口腔黏膜炎和营养状况
[J]. 肿瘤代谢与营养电子杂志, 2022, 9(4): 502-506.
Yin Qiujie,Tang Yuanyuan, Wang Ji, Hua Yuchen. Effects of vitamin B2
combined with Kangfuxin Solution on oral mucositis and nutritional status of patients with head and
neck cancer after radiotherapy. Electron J Metab Nutr Cancer, 2022, 9(4): 502-506.
