Investigation and analysis of influencing factors of sarcopenia in hospitalized patients with malignant tumors
1 2Zhang Lingling ,1 3Zheng Zheng ,1He Li ,1 3Li Na ,1 3An Yonghui ,2 3Li Zengning
1Department of Oncology The First Hospital of Hebei Medical University Shijiazhuang 050031 Hebei China
2Department of Clinical
Nutrition The First Hospital of Hebei Medical University Shijiazhuang 050031 Hebei China
3Key Laboratory of Nutrition and Health
of Hebei Province Shijiazhuang 050031 Hebei China
Abstract：Objective To investigate the occurrence of sarcopenia in hospitalized patients with malignant tumor analyze the related
influencing factors and compare the differences in body composition serological indicators and quality of life between the sarcopenia
group and the non-sarcopenia group so as to provide clinical data for improving the prognosis of patients. Method A total of 321
hospitalized patients with malignant tumor were collected and their body composition was measured by multi-frequency bioelectrical
impedance analyzer. Sarcopenia was diagnosed according to the Asian Sarcopenia Working Group AWGS diagnostic criteria and
divided into sarcopenia group and non-sarcopenia group. Nutritional status was assessed by patient subjective global assessment PGSGA systemic inflammatory response was assessed by improved Glasgow outcome score mGPS and quality of life was assessed by
the European Quality of Life Collaboration Group cancer core scale QLQ-C30 . Univariate and multivariate Logistic regression were
used to analyze the factors affecting the occurrence of sarcopenia. T test and rank sum test were used to compare the differences of body
composition serological indexes and quality of life between the two groups. 0. 05 means the difference is statistically significant. Result
In this study 102 patients were diagnosed with sarcopenia with an incidence of 31. 78% . The results showed that there were
statistically significant differences in the incidence of sarcopenia among different PG-SGA body mass index BMI mGPS groups P<
0. 05 and BMI was an independent factor affecting the incidence of sarcopenia patients with body weight and hemoglobin albumin
triglyceride were significantly lower than those without sarcopenia patients while extracellular moisture ratio was higher than those
without sarcopenia. The scores of functional domains and symptom domains in quality of life were lower than those in patients without
sarcopenia and the scores of constipation and anorexia were higher than those in patients without sarcopenia with statistically
significant differences P<0. 05 . Conclusion The incidence of sarcopenia in hospitalized patients with malignant tumors is related to PG-SGA BMI and mGPS and BMI is an independent factor affecting the incidence of sarcopenia. Sarcopenia results in low body
weight poor nutritional status high systemic inflammatory response score low phase angle level and poor quality of life.
