Study on probiotics combined with prebiotics to prevent the incidence of acute radiation enteritis in patients with cervical cancer
1Chen Xiaoli，2Rao Hui，3Lang Chunhui，4Liu Huawen，5Cheng Yu，2He Yan
1Nursing Department Three Gorges Hospital Affiliated to Chongqing University Chongqing 404000 China
2Comprehensive Tumor Radiotherapy Ward Three Gorges Hospital Affiliated to Chongqing University Chongqing 404000 China
3
Scientific Research and Foreign
Affairs Department Three Gorges Hospital Affiliated to Chongqing University Chongqing 404000 China
4Medical Department Three
Gorges Hospital Affiliated to Chongqing University Chongqing 404000 China
5Medical Laboratory Three Gorges Hospital Affiliated to
Chongqing University Chongqing 404000 China
Abstract：Objective To explore the effect of probiotics combined with prebiotics in reducing the incidence of radiation enteritis in
patients with cervical cancer. Method From November 2019 to November 2021 82 patients with cervical cancer who received radiotherapy for the first time from Three Gorges Hospital Affiliated to Chongqing University were randomly divided into control group and
observation group depending on the way of nutrition. The control group was treated with routine treatment and basic nursing and the
observation group was treated with probiotics and prebiotics on the basis of the control group. There was no difference in age pathological type and cervical cancer stage between the two groups all P > 0. 05 . Before and 7 days after radiotherapy compare the inflammatory factors interleukin-1 IL-1 interleukin-6 IL-6 tumor necrosis factor-α TNF-α number of bowel sounds immunoglobulin level immunoglobulin G IgG immunoglobulin A IgA immunoglobulin M IgM the incidence of radiation enteritis and the
incidence of severe radiation enteritis were compared between the two groups one week after radiotherapy. Result Before radiotherapy
there was no significant difference in the levels of inflammatory factors immunoglobulin and the number of bowel sounds between the
two groups all P > 0. 05 7 days after radiotherapy the levels of inflammatory factors IL-1 IL-6 TNF-α in the observation
group and the number of bowel sounds in the observation group were lower than those in the control group and the levels of IgG IgA
and IgM in the observation group were higher than those in the control group. The difference between the two groups was statistically
significant all P < 0. 05 . 7 days after radiotherapy the incidence of radiation enteritis and severe radiation enteritis in the observation group were lower than those in the control group P < 0. 05 . Conclusion Probiotics combined with prebiotics can reduce the incidence of radiation enteritis in patients with cervical cancer.
收稿日期: 2022-06-18
基金资助:重庆市科卫联合面上项目(2018MSXM007)
通讯作者:
饶 辉,电子邮箱:2363779173@qq.com
引用本文:
1陈晓莉,2饶 辉,3郎春辉,4刘华文,5程 宇,2何 燕. 益生菌联合益生元预防宫颈癌患者急性放射性肠炎的研究[J]. 肿瘤代谢与营养电子杂志, 2022, 9(3): 340-344.
1Chen Xiaoli，2Rao Hui，3Lang Chunhui，4Liu Huawen，5Cheng Yu，2He Yan. Study on probiotics combined with prebiotics to prevent the incidence of acute radiation enteritis in patients with cervical cancer
. Electron J Metab Nutr Cancer, 2022, 9(3): 340-344.
