Abstract： Mitochondria are the organelles of the eukaryotic cells that oxidize phosphorylation to produce ATP and are closely related to cell energy metabolism, cell apoptosis, oxidative stress, calcium homeostasis control and so on. Mitochondria have mitochondrial DNA(mtDNA), a genetic material independent of nuclear genes. mtDNA is the only genetic material outside nuclear,because of its unique structural characteristics and biological environment, which is prone to mutation with about 10 times the rate to nuclear genome. A large number of research show that mtDNA is highly related to the occurrence and development of human tumor. Cervical cancer(CC) is the most common gynecologic malignant tumor that endangers human health. Its incidence is the second of female malignant tumor in the world, second only to breast cancer.With the development of the economy and society, the spectrum of human disease has changed greatly. But the incidence and mortality of CC remain high. There are many studies on the correlation between the genome nucleus and cervical carcinoma, but the research on genome outside the nuclear are rare.In recent years, study
on relationship between mtDNA and CC has become a hot research topic. Mutations in mtDNA include qualitative mutations, such as base substitution, insertion or deletion, and changes in the content of mtDNA, etc. Many previous studies include the effect of mtDNA mutation on different aspect of CC. This paper reviews the relevance between the mutation of mtDNA and occurrence,development, prognosis of CC.
