The potential role of sulforaphane in breast cancer, ovarian cancer and cervical cancer
Zhang Wei1, Li Suyi2
1Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 101191, China；2Department of Tumor Nutrition and Metabolism, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230000, Anhui, China
Abstract：As our understanding of the genetic and environmental factors that glucosinolates accumulate in plants and the effects of these compounds and their derivatives has increased, so has our understanding of the role glucosinolates and their products may play in reducing the risk of cancer and heart disease when consumed as part of a diet. After absorption and distribution in the body, they will affect the general defensive mechanisms of the body, including the prevention and treatment of tumors.It has been found that the combination of these bioactive substances with traditional anti-tumor therapies can improve the effectiveness of anti-tumor therapy.Sulforaphane is a homologous isothiocyanate mainly found in brassica vegetables.Evidence shows that the intake of sulforaphane is significantly negatively correlated with cancers such as breast cancer and ovarian cancer. It may be that sulforaphane can regulate cell growth in addition to improving the detoxification and antioxidant capacity of cells, which is particularly important for cancer prevention.The mechanism of cell inhibition and cytotoxicity of sulforaphane includes induction of cell apoptosis, inhibition of cell cycle progression and inhibition of angiogenesis, targeting multiple sites of key cell signaling pathways of tumor cells, and playing an anti-tumor effect similar to that of targeted drugs.This review introduces the possible mechanism of sulforaphane in clinical adjuvant chemotherapy and radiotherapy for breast cancer, ovarian and cervical cancer, and provides theoretical clues for its clinical application in breast cancer and ovarian and cervical cancer.
张维，李苏宜. 萝卜硫素在乳腺癌、卵巢癌及宫颈癌中的潜在作用[J]. 肿瘤代谢与营养电子杂志, 2020, 7(4): 391-395.
Zhang Wei, Li Suyi. The potential role of sulforaphane in breast cancer, ovarian cancer and cervical cancer. Electron J Metab Nutr Cancer, 2020, 7(4): 391-395.
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