Research progress on the relationship between celastrol and tumor metabolism
1 Li Ye,2 Song Mengmeng,3 Chang Wenjun,4 Miao Mingyong,1 Pan Yamin
1Endoscopy center, Shuguang Hospital affiliated to Shanghai University of traditional Chinese Medicine, Shanghai 201203, China； 2Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450002,Henan, China； 3Department of Environmental Health, Second Military Medical University, Shanghai 200433,China； 4Department of Biochemistry and Molecular Biology, The College of Basic Medical Sciences, The Second Military Medical University, Shanghai 200433, China
Abstract：Celastrol is an active ingredient of Chinese herbal medicine with extensive therapeutic properties and high medicinal value. It is commonly used in the treatment of autoimmune diseases, metabolic diseases and cancer. Celastrol can inhibit the occurrence and development of tumor through a variety of ways, especially closely related to tumor metabolism, and has an important impact on the metabolism of sugar metabolism, lipid metabolism, amino acid metabolism and tumor microenvironment of tumor cells. Celastrol causes mitochondrial dysfunction to alter the glucose metabolism pathway, resulting in insufficient energy supply to tumor cells； affects lipid metabolism in tumor hosts by inducing liver Sirt1 expression； inhibits the progress of colorectal cancer by inhibiting indoleamine 2,3 dioxygenase (IDO) expression and tryptophan catabolism, controls pancreatic cancer by combining with IDO inhibitor D-1MT. In the tumor microenvironment, celastrol can treat melanoma by inhibiting NLRP3 inflammatory bodies and remodeling immunosuppression. According to the latest research, the high metabolism of intestinal flora can improve the efficacy of celastrol in the body, affecting the development of tumors. This review describes the main effects and mechanisms of celastrol on tumors from a metabolic perspective, providing a scientific basis for its in-depth study of pharmacological effects.
李晔，宋蒙蒙，常文军，缪明永，潘亚敏. 雷公藤红素与肿瘤代谢的关系研究进展[J]. 肿瘤代谢与营养电子杂志, 2020, 7(1): 18-21.
Li Ye,Song Mengmeng,Chang Wenjun,Miao Mingyong,Pan Yamin . Research progress on the relationship between celastrol and tumor metabolism. Electron J Metab Nutr Cancer, 2020, 7(1): 18-21.
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