Effect of oral supplement of β-hydroxy-β-methylbutyric acid on elderly patients with hip fracture
1ZUO Dan,2HUANG Biao,3LUO Chun-li,4ZHONG Lan
1Department of Clinical Nutrition,Chongqing Dazu District Peoples Hospital,Dazu 402360,Chongqing,China；2Department of Critical Medicine,Chongqing Dazu District Peoples Hospital,Dazu 402360,Chongqing,China；3Department of Oncology,Chongqing Dazu District Peoples Hospital,Dazu 402360,Chongqing,China；4Department of Clinical Nutrition,Chongqing Liangping District Peoples Hospital,Liangping 402360,Chongqing,China
Abstract：ObjectiveTo investigate the clinical efficacy of β-hydroxy-β-methylbutyrate acid in the treatment of muscular dystrophy in elderly patients with hip fracture. Methods From January 2018 to March 2019, the elderly patients with hip fracture who met the inclusion criteria were randomly divided into experimental group （n=30） and control group （n=28）. The control group was given conventional nutrition treatment, and the experimental group was treated with HMB on the basis of the control group. The weight, total protein, albumin, creatinine, grip strength, appendant skeletal muscle mass （ASMM）, the number of cases of pulmonary infection and the number of cases with Barthel index>40 were monitored and compared between the two groups at three time points （0, 3, 6 weeks）. ResultsThe body weight, total protein, albumin and creatinine of the patients in the experimental group increased significantly （P<0.05）. The ASMM of experimental group and control group decreased, but the difference was statistically significant （P<0.05）. There was no significant difference in grip strength （P>0.05）. The incidence of pulmonary infection in the control group was significantly higher than that in the experimental group （P<0.05）. The number of people whose Barthel index was more than 40 points was significantly higher than that of the control group （P<0.05）. ConclusionThrough the clinical study of HMB in the treatment of myopenia in elderly patients with hip fracture, it has obvious effects in inhibiting muscle and protein decomposition, increasing lean muscle and improving malnutrition status of patients. The incidence of pulmonary infection is relatively small, which can reduce the risk of death of patients, promote their rehabilitation and enhance their self-care ability to a certain extent. Prevention and reduction of muscle loss in hospitalized patients is one of the treatment factors clinicians should consider, so HMB should be better applied in the field of nutrition therapy. Whether HMB is effective for other diseases, such as tumors, liver transplantation and so on, still needs a lot of clinical experiments and evaluation methods to further study its clinical effect.
1左丹，2黄彪，3罗春丽，4钟岚. β-羟基-β-甲基丁酸口服补充对髋部骨折老年患者的影响[J]. 肿瘤代谢与营养电子杂志, 2019, 6(4): 462-467.
1ZUO Dan,2HUANG Biao,3LUO Chun-li,4ZHONG Lan. Effect of oral supplement of β-hydroxy-β-methylbutyric acid on elderly patients with hip fracture. Electron J Metab Nutr Cancer, 2019, 6(4): 462-467.
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