尿路上皮癌患者化疗期间营养风险及影响因素研究

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摘要目的探讨尿路上皮癌患者化疗期间营养状况,并分析其影响因素。方法选取南京鼓楼医院 2021 年 1 月至 2023 年 1 月泌尿外科收治的尿路上皮癌患者 180 例。采用营养风险筛查 2002(NRS 2002)量表评估患者入院 24 h 内营养风险,并对尿路上皮癌患者化疗期间营养状况的影响因素进行单因素分析与多因素 Logistic 回归分析。结果经 NRS 2002 评估,180 例患者中存在营养风险者 73 例,占 40. 56%,无营养风险者 107 例,占 59. 44%。存在营养风险者血清总蛋白、血清白蛋白水平均低于无营养风险者(P<0. 05)。经单因素分析可见,存在营养风险者年龄、体质量指数、家庭人均月收入、临床分期,以及抑郁、呕吐、手术构成比与无营养风险者比较,差异有统计学意义(P<0. 05)。经多因素 Logistic 回归分析可见,年龄、家庭人均月收入、临床分期、抑郁、呕吐、血清总蛋白水平、血清白蛋白水平是影响尿路上皮癌患者化疗期间营养状况的危险因素(P<0. 05)。结论年龄、家庭人均月收入、临床分期、抑郁、呕吐、血清总蛋白水平、血清白蛋白水平是影响尿路上皮癌患者化疗期间营养状况的主要因素。

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	李慧慧
	陈慧
	王良梅
	张小青

关键词 ：尿路上皮癌, 化疗, 营养状况, 影响因素

Abstract：Objective To investigate the nutritional status of patients with urothelial carcinoma during chemotherapy and analyze its influencing factors. Method From January 2022 to January 2023 180 patients with urothelial carcinoma admitted to the urological department in our hospital were selected. Nutritional risk screening 2002 NRS 2002 was used to assess the nutritional risk of patients within 24 hours of admission and univariate analysis and multivariate logistic regression analysis were conducted to analyze the influencing factors of nutritional status of patients with urothelial carcinoma during chemotherapy. Result According to NRS 2002 evaluation 73 out of 180 patients had nutritional risk accounting for 40. 56% and 107 out of 180 patients had no nutritional risk accounting for 59. 44%. The serum total protein and albumin levels of individuals with nutritional risk were lower than those without nutritional risk P<0. 05 . Through univariate analysis it can be seen that there is a statistically significant difference in age body mass index per capita monthly income of families clinical staging depression vomiting and surgical proportion between individuals at nutritional risk and those without nutritional risk P<0. 05 . Through multiple factor analysis it can be seen that age per capita monthly income of the family clinical stage depression vomiting serum total protein and serum albumin levels are independent risk factors that affect the nutritional status of patients with urothelial carcinoma during chemotherapy P<0. 05 . Conclusion Age average monthly family income clinical stage depression vomiting serum total protein and serum albumin levels are the main factors affecting the nutritional status of patients with urothelium cancer during chemotherapy.

Key words： Epithelial carcinoma of the urinary tract Chemotherapy Nutritional status Influence factor

基金资助:南京鼓楼医院院级课题(2022-B1288)

通讯作者: 陈慧,电子邮箱:676207930@ qq.com

引用本文:

李慧慧,陈慧,王良梅,张小青. 尿路上皮癌患者化疗期间营养风险及影响因素研究[J]. 肿瘤代谢与营养电子杂志, 2024, 11(1): 60-64.
Li Huihui，Chen Hui， Wang Liangmei， Zhang Xiaoqing. Study on nutritional risk and influencing factors of patients with urothelial carcinoma during chemotherapy. Electron J Metab Nutr Cancer, 2024, 11(1): 60-64.