Prognostic value of nutritional index body mass index and N stage before chemoradiotherapy in prognostic prediction of
nasopharyngeal carcinoma patients
1Department of Otolaryngology the Second Affiliated Hospital of Chengdu Medical College?? No. 416 Hospital of Nuclear Industry
Chengdu 610051 Sichuan China
2Department of Oncology the Second Affiliated Hospital of Chengdu Medical College?? No. 416
Hospital of Nuclear Industry Chengdu 610051 Sichuan China
3Department of Oncology the Second Affiliated Hospital of Chengdu
Medical College?? No. 416 Hospital of Nuclear Medicine Department Chengdu 610051 Sichuan China
Abstract：Objective To discuss the application value of prognostic nutritional index PNI body mass index and N stage before
radiotherapy in predicting the clinical outcome of nasopharyngeal carcinoma NPC patients undergoing radiochemotherapy. Method
From January 2010 to December 2015 128 NPC patients undergoing radiochemotherapy in No. 416 Hospital of the nuclear industry
were selected and retrospectively analyzed their general information treatment plan laboratory examination pathology and imaging
data. The clinical outcomes were followed up until December 20 2021. Kaplan-Meier method was used to draw the survival curve. Log
rank χ2
Test and Cox regression analysis was used to explore the prognositic factors of nasopharyngeal carcinoma patients. Result The
mortality was 21. 88% during the median at 69. 5 months follow- up. The 3 - year and 5 - year survival rates of 128 patients were
94. 53% and 80. 47% respectively. Receiver operating characteristic ROC curve showed that albumin ALB lymphocyte LYM
PNI white blood cell WBC and body mass index BMI were statistically significant in predicting the survival rate of patients P<
0. 05 with cut-off values at 37. 5 g / L 1. 75 × 10
9
/ L 45. 0 4. 55 × 10
9
/ L and 21. 85 kg / m
2
respectively. Univariate analysis
showed that PNI ALB LYM and WBC were all risk factors for prognosis while tumor stage T stage N stage and BMI were all
protective factors for prognosis. Multivariate Cox regression showed that PNI ≥ 45. 0 and BMI ≥ 21. 85 kg / m
2 were protective factors
while N stage 2 to 3 was a risk factor for the prognosis of nasopharyngeal carcinoma patients with HR 95%CI 0. 784 0. 725-0. 847 、
0. 824 0. 700-0. 970 and 4. 289 1. 737 - 10. 589 respectively P < 0. 05 . Conclusion The nutritional status of nasopharyngeal carcinoma patients before radiochemotherapy is related to the clinical prognosis. PNI BMI and N stage can be used as independent
prognostic factors of nasopharyngeal carcinoma patients.
1罗蓓蓓,2贺 丹,3江 雪,1李姿霖,1何林静,2吴小林. 放化疗前预后营养指数、体质指数及 N 分期在鼻咽癌患者预后预测中的应用价值探索[J]. 肿瘤代谢与营养电子杂志, 2023, 10(6): 785-791.
1Luo Beibei,2He Dan,3Jiang Xue,1Li Zilin,1He Linjing,2Wu Xiaolin. Prognostic value of nutritional index body mass index and N stage before chemoradiotherapy in prognostic prediction of
nasopharyngeal carcinoma patients. Electron J Metab Nutr Cancer, 2023, 10(6): 785-791.
