Abstract：Objective To evaluate the correlation between nutritional status and radiation – induced oral mucositis ROM in
nasopharyngeal carcinoma NPC patients during radiotherapy so as to provide a reference for clinical improvement of radiotherapy
effect reduction of radiotherapy complication and improvement of nutrition supply. Method A total of 154 patients with NPC
diagnosis for the first time into our hospital from May 2020 to May 2022 were enrolled retrospectively. They received intensity
modulated radiation therapy IMRT or chemoradiotherapy for at least 4 weeks. Compare the nutritional indicators before and 4 weeks
after radiotherapy including body weight body mass index BMI hemoglobin albumin and prealbumin levels and the nutritional
risk screening score 2002 NRS 2002 score. After radiotherapy grade of ROM severity according to the American Common Adverse
Reaction Terminology Assessment Standard CTCAE Version 5. 0 that is no mild to moderate and severe groups. Compare the
nutritional indicators and nutritional intervention methods during the ROM groups. Result The body weight BMI albumin and
prealbumin of 154 patients decreased significantly after radiotherapy while the NRS 2002 score increased significantly P< 0. 05 .
After radiotherapy there were 41 cases in the non ROM group 91 cases in the mild to moderate group and 22 cases in the severe
group. There were no differences among the three groups of all the nutritional indicators before radiotherapy P > 0. 05 . After
radiotherapy the weight BMI hemoglobin albumin and prealbumin in the severe group were significantly lower than those in the mild
to moderate group and the reduction of each indicator was significantly higher than that in the mild to moderate group the NRS 2002
score and increasement were significantly higher than those in the mild to moderate group too P<0. 05 there were also differences
between the mild to moderate group and the non ROM group P<0. 05 . In severe group enteral nutrition was significantly more than that
in mild to moderate group the time of parenteral nutrition supply was significantly longer and the total energy of nutrition supply was
significantly higher there were also differences between the mild to moderate group and the non ROM group too P<0. 05 . Conclusion
ROM occurrence is closely related to nutritional status which can influence and interact with each other in NPC patients during IMRT
improving radiotherapy technology and reducing the risk of ROM are important method to improve nutritional status.
收稿日期: 2023-01-07
基金资助:国家自然科学基金项目(82102831)
通讯作者:
程敏琼,电子邮箱:1911651121@ qq. com
引用本文:
许文秀,程敏琼. 鼻咽癌放疗营养状况与放射性口腔黏膜炎的相关研究[J]. 肿瘤代谢与营养电子杂志, 2023, 10(3): 395-400.
Xu Wenxiu,Cheng Minqiong. Study on the relationship between nutritional status and radiation - induced oral mucositis in nasopharyngeal carcinoma
during radiotherapy. Electron J Metab Nutr Cancer, 2023, 10(3): 395-400.
