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2014 Vol. 1, No. 1
Published:
 
3 Neo-therapy for Cancer: Metabolism Regulation
2014 Vol. 1 (1): 3-5 [Abstract] ( 234 ) HTML PDF (5117 KB)  ( 269 )
6 Novel Concepts of Cancer Supportive Care
2014 Vol. 1 (1): 6-9 [Abstract] ( 196 ) HTML PDF (7377 KB)  ( 249 )
10 COX-2 Inhibitor and Cancer: far from Analgesia
2014 Vol. 1 (1): 10-14 [Abstract] ( 162 ) HTML PDF (8214 KB)  ( 237 )
15 Clinical Strategies for Reducing Glucose level in Survival Environment of Malignancies
2014 Vol. 1 (1): 15-17 [Abstract] ( 190 ) HTML PDF (5109 KB)  ( 218 )
18 Weight Loss in Cancer Patients
2014 Vol. 1 (1): 18-20 [Abstract] ( 183 ) HTML PDF (7487 KB)  ( 254 )
21 Carnitine: more than a Carrier
2014 Vol. 1 (1): 21-25 [Abstract] ( 195 ) HTML PDF (8273 KB)  ( 226 )
26 Vitamin B1 : Old Drug and New Stories
2014 Vol. 1 (1): 26-29 [Abstract] ( 184 ) HTML PDF (7705 KB)  ( 210 )
30 Sarcopenia or Myopenia？
2014 Vol. 1 (1): 30-32 [Abstract] ( 244 ) HTML PDF (6015 KB)  ( 212 )
36 Effects of Docosahexaenoic Acid on Proliferation and Lipid Peroxidation of Esophageal Carcinoma Cell
Abstract：Objective To investigate the effects of docosahexaenoic acid (DHA) on proliferation and lipid peroxidation (LPO) of esophageal adenocarcinoma cells (EAC) and esophageal squamous carcinoma cells (ESCC) . Methods The Eca-109 (ESCC) and OE-19 (EAC) cells were treated with DHA in three different concentrations (100, 50, 1μmol/L) for 24 h. Cell proliferation was assessed by Cell Counting Kit-8 assay. The concentrations of superoxide dismutase (SOD), malonaldehyde (MDA) and nitric oxide (NO) were determined by WST-1, TBA and nitrate reductase method, respectively. Results Cell growth of OE-19 was inhibited by DHA in a concentration-dependent manner (P<0.05), while suppression of Eca-109 was only found in high concentration (100μmol/L) (P<0.05). In both groups, the levels of MDA and NO were increased in a concentration-dependent manner after DHA treatment (P<0.05). For Eca-109 cells, the inhibition of SOD activities were merely found in 100 μmol/L group (P<0.05), while the SOD levels in OE-19 cells showed a down-regulation after treatment of DHA in 1 and 50 μmol/L, but were sharply increased in 100 μmol/L treated group(P<0.05). Conclusions DHA treatment results in a steady growth inhibition in EAC cells, but not in ESCC cells. Activation of LPO is found in both Eca-109 cells and OE-19 cells after DHA treatment. Balance between LPO and SOD in EAC and ESCC may play a key role in the DHA induced cell growth inhibition.
2014 Vol. 1 (1): 36-39 [Abstract] ( 240 ) HTML PDF (6866 KB)  ( 247 )
40 Value of Early Enteral Nutritional Support in Patients after Laryngeal Cancer Surgery
Abstract：Objective To evaluate the efficiency of early enteral nutritional support in patients underwent laryngectomy. Methods We retrospectively reviewed and analyzed 329 larynx cancer patients underwent total or partial laryngectomy from November 2003 to July 2013 in Daping Hospital. Of these patients, 278 (EN group) were given enteral nutrition with commercial formulations within 24 hours after the surgery through the nasogastric tube, 51 patients (Convenience diet group， CD group) rejected the enteral nutrition treatment and were on homogenated diet. We compared the rate of fistula formation, post-surgical infection rate, average length of hospitalization, and other clinical indicators between the two groups. Results 13 patients (13/278, 4.68%) in the EN group, and 6 patients (6/51, 11.76%) in the CD group had fistula formation. The difference is found statistically significant (P<0.046). The differences of post-surgical infection rate, average length of hospitalization and other clinical indicators between the two groups are not statistically significant. Conclusions The risk of fistula formation may be shortened in patients underwent laryngectomy by giving early enteral nutrition.
2014 Vol. 1 (1): 40-44 [Abstract] ( 216 ) HTML PDF (10594 KB)  ( 289 )
45 Oral Hydrolyzed Protein Improve the Nutritional Status of Patients with Gastrointestinal Cancer
Abstract：Objective To evaluate the therapeutic efficacy of oral hydrolyzed protein in the patients with gastrointestinal cancer. Methods Sixty cases of gastrointestinal cancer patients were prospectively included and then randomly divided into experimental group and control group; There were thirty cases in each group. The experimental group received routine nutritional support with daily oral 30g hydrolyzed protein; the control group only received routine nutritional support. Two groups accepted seven days continuous treatment. Hereafter we tested the related nutrition indicators and compared the differences between before and after treatment in two groups. Results During the treatment, the ratios of gastrointestinal complications in two groups were no significant difference. After nutritional support, the lymphocyte count, hemoglobin, total protein, albumin, globulin, pre-albumin, transferrin and HDL cholesterol in experimental group were higher than before treatment, but C-reactive protein was lower than before, the difference was statistically significant (P=0.031). However, compared with before treatment, only pre-albumin in control group was significant difference (P=0.028). After treatment, total protein, albumin, pre-albumin and transferrin in test group improved higher than control group (P=0.013, 0.001, 0.045, 0.048, respectively). Conclusions Common nutritional therapy, which combines with oral hydrolyzed protein in malnourished patients with gastrointestinal cancer, has a well adherence and tolerability and improves the patients' nutritional status.
2014 Vol. 1 (1): 45-50 [Abstract] ( 222 ) HTML PDF (10449 KB)  ( 223 )
56 Chemoprotection against Lung Cancer by Phytochemicals
Abstract：Objective To elaborate chemoprevention of phytochemicals for lung cancer and look forward to its application prospect. Methods Taking Cruciferous vegetables and its bioactive components isothiocyanates as an example, research advances of chemoprevention of phytochemicals for lung cancer would be reviewed in terms of epidemiological studies, animalexperiments, clinical research and its action mechanism. Results Cruciferous vegetables could reduce the risk of lung cancer, which was independent of smoking. Phytochemicals rich in cruciferous vegetables named as isothiocyanates could inhibit animal model suffering from lung cancer induced by a variety of carcinogens. A diet rich in broccoli could enhance the immunity of respiratory system and improve the detoxification ability toenvironment carcinogens. The multiple mechanisms of cancer chemoprotective effect involved inhibition of the carcinogen activation, induction of protective enzymes, suppression of inflammation reaction, regulation of immunity, interruption of cell cycle, promotion of apoptosis and perturbation of signaling pathways. Conclusions Food and its extract rich in plant chemicals could serve as prospective alternatives for prevention of lung cancer.
2014 Vol. 1 (1): 56-59 [Abstract] ( 185 ) HTML PDF (7906 KB)  ( 218 )
60 Antioxidants in Cancer Prevention
Abstract：Objective Existing data indicate that oxidative damage involved in the process of cancer development and progression. The impact of antioxidants on cancer occurrence and development has been a hot research topic. In this paper, we review the literature of the effect of antioxidants on the cancer development and progression. Methods We review the domestic and foreign published literature of antioxidants on the mechanism of cancer occurrence, and the effect of antioxidants on cancer patients during radiotherapy and chemotherapy. Results Current studies show that using high doses of antioxidants during radiotherapy may reduce the anti-cancer effects from radiotherapy, and shorten the survival time. However, the mechanism is unknown. Use of antioxidants during chemotherapy does not affect the efficacy of chemotherapy, and can reduce the side effects from it. Most of the studies failed to confirm that anti-oxidants have any benefits in the prevention of cancer. Conclusions Use of antioxidants during chemotherapy does not affect the efficacy of chemotherapy, and can reduce the side effects from chemotherapy. Currently, most of the large randomized double-blind controlled trial failed to confirm that antioxidant supplements can decrease incidence and mortality of cancer.
2014 Vol. 1 (1): 60-64 [Abstract] ( 242 ) HTML PDF (10339 KB)  ( 227 )
65 Ubiquitin-proteasome System in Cancer Cachexia
Abstract:Objective To summarize the late advance of ubiquitin-proteasome system in cancer cachexia and conclude its regulatory mechanisms and possible targets of cachexia therapy. Methods Related articles were obtained through comprehensive search in the database Pubmed with the keywords“cancer, cachexia, ubiquitin, proteasome”. Results Dysregulated cytokines resulting from cancer bearing promote muscle protein degradation via ubiquitin-proteasome system, which benefits for initiation and progression of cancer cachexia. Conclusions The ubiquitin-proteasome system may be a novel target of cachexia therapy. Elucidation of how ubiquitinated proteins are specifically recognized by proteasome and identification of its upstream regulatory factors would contribute to improvement of clinical therapy in cachexia.
2014 Vol. 1 (1): 65-69 [Abstract] ( 226 ) HTML PDF (8252 KB)  ( 204 )
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