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| Ubiquitin-proteasome System in Cancer Cachexia |
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Abstract Abstract:Objective To summarize the late advance of ubiquitin-proteasome system in cancer cachexia and conclude its regulatory mechanisms and possible targets of cachexia therapy. Methods Related articles were obtained through comprehensive search in the database Pubmed with the keywords“cancer, cachexia, ubiquitin, proteasome”. Results Dysregulated cytokines resulting from cancer bearing promote muscle protein degradation via ubiquitin-proteasome system, which benefits for initiation and progression of cancer cachexia. Conclusions The ubiquitin-proteasome system may be a novel target of cachexia therapy. Elucidation of how ubiquitinated proteins are specifically recognized by proteasome and identification of its upstream regulatory factors would contribute to improvement of clinical therapy in cachexia.
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| [1] |
WANG Chao-yun， DU Cheng， GUAN Xin， DU Xiao-wei， XU Zhu-xuan， ZHENG Zhen-dong. Advances in drug therapy for cancer cachexia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 382-385. |
| [2] |
1，2ZHU Ming-xing， 1WU Chang-peng， 3YIN Liang-yu，1LU Zong-liang， 1LI Na，1LIU Jie， 1GUO Jing， 1XU Hong-xia. L-carnitine improves skeletal muscle cell atrophy of cancer cachexia by regulating lipid metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(3): 320-325. |
| [3] |
LI Wei， GUO Zi-xing， LI Yong-hong， LIU Xiao-ping， HUANG Jing-yu， HU Wei-dong， LI Sheng. Analysis of expression and its clinical significance of UBE2T in lung cancer based on GEO database[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(2): 242-245. |
| [4] |
1CAI Jun-xiang, 2LOU Hui-ling . Sarcopenia[J]. Electronic Journal of Metabolism and Nutrition of, 2019, 6(1): 135-143. |
| [5] |
GUAN Chun-yan, NIU Hui-yan. Research progress in cancer cachexia-induced regulation of skeletal muscle oxidative metabolism[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(4): 342-347. |
| [6] |
1LIU Jin-peng 2LU Xiao-Lan. Biomarkers of carcinemia and cancer treatment related complications[J]. Electronic Journal of Metabolism and Nutrition of, 2018, 5(3): 247-250. |
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2014, Vol. 1 
