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| Research progress of CT relevant parameters in patients with gastrointestinal cancers |
| 1LI Yi, 2ZHOU Fu-xiang, 1LI Qin-yang, 1 HU Ke, 1LIU Xian-hao, 1XU Yi-jun, 1,3YU Chang-hua |
| 1Departmentof Hematology & Oncology, Clinical department of Carlson International Cancer Centre, General Hospital of Shenzhen University, Shenzhen 518000, China；2Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan 430071, Hubei, China； 3Shenzhen University Clinical Medical Academy, Shenzhen 518000, China |
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Abstract The degeneration of skeletal muscle is closely related to clinical outcomes of patients with carcinomas. CT is one of the commonly used diagnostic tools for patients with cancers, with high resolutions for skeletal muscles. The CT relevant parameters-SMD （skeletal muscle density） and SMI （skeletal muscle index）-reflect the quality （myosteatosis） and quantity （sarcopenia） for skeletal muscle. In this article, we collected literatures home and abroad through “pubmed and CNKI” to explore the clinical values of SMD and SMI among patients with gastrointestinal cancers. It was found that incidences of myosteatosis （low SMD） and myosteatosis （low SMI） are high, and the evaluation standards are gradually unified. However, the best cut-off value for myosteatosis （low SMD） and myosteatosis （low SMI） is still controversial. Furthermore, both myosteatosis （low SMD） and myosteatosis （low SMI） are associated with poorer treatment tolerance and clinical outcomes. In all, CT relevant parameters provide efficient tools in diagnosis and prognosis prediction for patients with gastrointestinal cancers, with important clinical application value.
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