肠道微生态与消化道肿瘤的研究进展

doi:10.16689/j.cnki.cn11－9349/r.2019.04.019

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Abstract The human microecosystem exists in the gastrointestinal tract, oral cavity, urogenital tract, respiratory tract, skin, and other parts of bodies, which is the most important and complex in the intestine. Intestinal microecology is involved in the development of the body, immune regulation, endocrine metabolism and other functions, and also affected by age, diet, antibiotics, psychological pressure, stress and other factors. The imbalance of intestinal microecology may cause many diseases, including skin diseases, obesity, infectious diseases, cardiovascular and cerebrovascular diseases and autoimmune diseases. With the development of intestinal microecology and gastrointestinal diseases, more and more scholars have found that the development of gastrointestinal tumors are significantly related to intestinal flora imbalance. The imbalance of intestinal flora directly or indirectly affects the development of tumor through the direct contact between microorganism and tumor, the regulation of body immunity, the production of bacterial metabolites and other mechanisms. Additionally, recent studies showed that intestinal microecology is closely related to the efficacy of various immunosuppressive checkpoint inhibitors, such as anti-programmed cell death protein-1 antibody, anti-programmed cell death protein ligand-1 antibody and anti-cytotoxic T lymphocyte associated antigen-4 antibody, which may be a potential biomarker to predict the efficacy of tumor immunotherapy. The paper summarizes the function of intestinal microecology and its role in the development of gastrointestinal cancer, hoping to provide reference for the future research focus and development direction.

Key words： Intestinal microecology Gastric cancer Rectal cancer Liver cancer Immunotherapy

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	ZHU Ya-ping
	GUO Heng-zhao

Cite this article:

ZHU Ya-ping,GUO Heng-zhao. Advances in intestinal microecology and gastrointestinal cancer[J]. Electron J Metab Nutr Cancer, 2019, 6(4): 488-493.

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http://182.92.200.144/EN/10.16689/j.cnki.cn11－9349/r.2019.04.019 OR http://182.92.200.144/EN/Y2019/V6/I4/488

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